1. haidut

    Obesity is estrogen-driven; Chronic fasting burns mostly muscle, not fat

    I wanted to do a quick post on this, as this topic is one of the most discussed in both medicine and society in general. Namely, whether fasting is a good and healthy approach to weight loss, which is largely determined by whether the weight we lose during fasting is mostly fat or muscle. Even...
  2. haidut

    Fasting/exercise/lowcarb/keto may promote cancer (melanoma) metastasis

    Quite the title for this post, but I think the evidence from the study below is clear. Namely, chronic activation of the so-called "master metabolic sensor" AMPK is a key mechanism through which melanoma cells rewire their metabolism from higher into lower OXPHOS, change their physical structure...
  3. haidut

    Regaining weight post diet/exercise due to lowered metabolism by increased PUFA in cardiolipin

    This is by far the most significant study I have seen come out in the last 2-3 years, simply because of the impact it has on virtually every person out there who has tried to lose excess weight (and who hasn't?). Virtually every person considering (or having done) dieting/exercise to lose excess...
  4. haidut

    Aspirin may replicate the benefits of fasting, while avoiding its risks

    I just made a post about fasting raising risk of early death by about 30%. On the other hand, fasting has been shown to lower biomarkers of inflammation as well as increase autophagy, with at least the former being undeniably beneficial. We already know from other studies that the benefits of...
  5. haidut

    Low-carb/fasting raise, low-fat diets lower risk of early death by 30%+

    Not very good news for the low-carb proponents, especially considering the fact that those findings match the clinical studies showing that pharmacologically lowering blood sugar increases all-cause mortality by about the same percentage (30%-40%). The study found that even the better-controlled...
  6. Tarmander

    Rapamycin is Fantastic and Worth Trying

    There really has not been much talk of Rapamycin on this forum. When it was brought up in the past, its mTOR inhibition was often talked about as a negative. Many assumed this would lead to muscle wasting and catabolism. Well I am here to tell you, it is worth looking into. Alone it has given...
  7. Inaut

    6 Months On Orange Juice

  8. haidut

    Fasting decreases androgens, increases aldosterone (and possibly cortisol/estrogens) in women

    I often get criticized that I rely too much on animal studies, so here is a human one that should give the proponents of caloric restriction / fasting a pause. Even a short fast (24-48 hours) resulted in decreased androgen synthesis in women, while increasing aldosterone. In general, fasting...
  9. haidut

    Fatty acid oxidation - linking all illness (especially cancer) with stress and diet (fasting / low-carb)

    The study below is one perhaps the most comprehensive review published to date, challenging the medical dogma that cancer is a genetic/mutation disease. As the study aptly explains, the evidence, spanning as far back as Otto Warburg's original work on this disease, is overwhelmingly in support...
  10. haidut

    Malnutrition (fasting) or protein deficiency sufficient to cause diabetes

    Yet another study that should give a pause to all health care providers who push their patients to lose weight at any cost - i.e. "lower is always better", when it comes to BMI, as the dogma goes. Well, apparently not, according to the study below. The even more astounding fact is that it looks...
  11. tastyfood

    Do you always fast before your blood tests?

    I test regularly for things like prolactin, TSH, total cholesterol, and other important tests. I typically test early in the morning, fasting, for consistency. I am starting to think if I should at least once test in a non fasting state. Being fasted is the most stressful time of the day, and...
  12. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
  13. haidut

    Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

    A very interesting and very "controversial" (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine "mysteries"...
  14. haidut

    Fasting ineffective for shrinking belly fat, may actually increase it

    Hopefully, this study will give some serious food for thought to people who use (intermittent) fasting (IF) with the goal of losing excess weight. A recent post of mine discussed that IF is ineffective for fat loss and actually leads to loss of lean mass. The lead author of that study, himself...
  15. Lokzo

    Ten days of complete fasting affected subjective sensations but not cognitive abilities in healthy adults - PUBMED 2021

    Ten days of complete fasting affected subjective sensations but not cognitive abilities in healthy adults Abstract Purpose: People may be unable to obtain anything edible for days under some circumstances, but they must maintain their calmness and cognition to navigate solutions. Our aim was...
  16. haidut

    Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

    A really interesting study, which will likely generate more than a few hateful emails for my Inbox :): Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER)...
  17. haidut

    Intermittent Fasting (IF) Ineffective And May Even Be Dangerous

    I have no doubt the findings of this study will quickly get dismissed by the massive industry that has formed around the idea that ANY weight loss is a good thing, and, just as importantly, if you lose weight while torturing yourself (in this with fasting) somehow the "gains" are even more...
  18. RealNeat

    New RP Interview (8/5) Says, "stop Eating For A While."

    @51:26 I think Peat just recommended fasting for weight loss. I believe and have experimented that it can be done, as long as the rest of the diet is adequate and isn't "restriction" based. Cyclic intermittent fasting with Peaty foods when eating.
  19. J

    New To The Forum. Been Doing A Experiement Here Recently

    I'm a new member to the forum, but I'm not exactly unfamiliar with Ray's ideas. I've been following his advice pretty closely for a few months now. Before applying some of Ray's ideas I was keto, and I had cold hands and feet all the time. I actually developed a pretty scary case of...
  20. haidut

    Down Syndrome (DS) Cognitive Handicap Is Due To (cellular) Stress, May Be Reversible

    If there is any disease that is currently considered incurable even in principles, it likely comes from the group of inherited/genetic disorders. Perhaps the most well-known one, due to rapidly rising incidence and thus publicity, is DS. Perhaps its most disabling aspect of DS is the cognitive...
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