Ten days of complete fasting affected subjective sensations but not cognitive abilities in healthy adults - PUBMED 2021


Mar 26, 2016

Ten days of complete fasting affected subjective sensations but not cognitive abilities in healthy adults​


Purpose: People may be unable to obtain anything edible for days under some circumstances, but they must maintain their calmness and cognition to navigate solutions. Our aim was to study changes in subjective sensations and cognition in healthy adults during a 10-day complete fasting experiment.

Methods: Thirteen healthy male volunteers voluntarily participated in the 22-day experiment comprising 4 phases: 3 days of baseline consumption, 10 days of complete fasting (only water ad libitum), 4 days of calorie restriction, and a 5-day recovery period. The volunteers' subjective sensations, cognitive performance, and serum energy substances were measured at 6 time points.

Results: Across the 6 time points, the trajectories of subjective sensations in response to fasting were "U"- or " ∩ "-shaped curves instead of progressive discomfort or mood enhancement. A significant fasting time effect was found on depression-dejection (baseline: 16.85 ± 2.88; highest score on the third day of completing fasting: 17.69 ± 3.97, P = 0.04) and self-rated anxiety (baseline: 26.23 ± 4.75; highest score on the sixth day of completing fasting: 30.85 ± 5.58, P = 0.01), and the change curves were consistent with the inflection point of the energy substrates shifting from serum glucose to ketone. In addition, basic cognitive functions appeared to be unaffected during the 10-day fast.

Conclusions: Our study showed strong influences on the sensations from the third to sixth days of the prolonged fasting period but no significant effects on basic cognitive abilities associated with the energy substance switch. These findings could contribute to the development and understanding of survival strategies in food-shortage emergencies or of intermittent fasting

Study Link: Ten days of complete fasting affected subjective sensations but not cognitive abilities in healthy adults - PubMed


Dec 12, 2020
Fasting greatly, greatly drives CO2 production.

I am considering starting some regular fasts, maybe a day a week, for the brain and psyche-protective effects.


Sep 3, 2020
Sources? Sounds interesting
Peat is against fasting for several reasons aka increased cortisol and lowered thyroid outputs why not just restrict pufa along with certain amino acids that will bring you greater benefit than pure fasting ?


Sep 22, 2020
Fasting greatly, greatly drives CO2 production.

I am considering starting some regular fasts, maybe a day a week, for the brain and psyche-protective effects.

Make sure you have nothing planned on those days. Well, for me, during my liver flushes, when you can’t eat for the day (until the night), it is a very miserable feeling. Maybe that it is one way of upregulating dopamine. Because eating after an extended fast is amazing.
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