Using High-dose Pregnenolone As An Anti-depressant

[Makrosky]

It's 2017, if you're not injecting preg then you're wasting your time

LOLLLL no need to inject it brah, there's an explanation why by haidut on another thread. Topical in a bulge vein works better.

 

[Makrosky]

Really? How does it work?

I'm willing to try

It's a different thing than oral or topical because it acts faster (effect fades away quicker also) and the dose has to be smaller of course. To me it gives some nice warming feeling coupled with anxiolytic effects.

It's more like for fun than anything else. If you try it please let me know!!!

 

[pimpnamedraypeat]

It's a different thing than oral or topical because it acts faster (effect fades away quicker also) and the dose has to be smaller of course. To me it gives some nice warming feeling coupled with anxiolytic effects.

It's more like for fun than anything else. If you try it please let me know!!!

Just tried it.....feeling a bit of slight endogenous heat in my limbs


5 minutes later I'm experiencing higher dopamine....clearer thinking....hmm

How much do you snort @Makrosky

 

[Makrosky]

Just tried it.....feeling a bit of slight endogenous heat in my limbs


5 minutes later I'm experiencing higher dopamine....clearer thinking....hmm

How much do you snort @Makrosky

Yeah I feel the endogenous heat as well. Specially in hands. Very nice.

I don't know. I just grab a small pinch... Hard to describe. Have you weighted yours ?

 

[pimpnamedraypeat]

Yeah I feel the endogenous heat as well. Specially in hands. Very nice.

I don't know. I just grab a small pinch... Hard to describe. Have you weighted yours ?

Mine is powder from the pregnenonone capsules i emptied into a small container. I havent weighed it but its not a lot

 

[Makrosky]

Mine is powder from the pregnenonone capsules i emptied into a small container. I havent weighed it but its not a lot

I'll see if I can weigh mine. I have a very precise scale. I think it is maybe... hmm... 5-12 mg max???

Anyway I think maybe mixing it with Snuff (tobacco) could be a great mental booster.

 

[Thomas PearTree]

Why don't you try lower doses of progesterone and aspirin? Both will raise your temp. Try working your way up to 300-900 mg of aspirin before bed; it will greatly reduce depressive feelings. Make sure to dissolve in hot water, add baking soda, glycine, and sugar: cool and drink drink.

I got tired of dissolving the bayer so I just take the pills but you've caught my attention with this cocktail. What's the rationale behind baking soda, glycine, and sugar in the aspirin water? And is collagen an ok substitute for glycine in this context?

 

[DaveFoster]

I got tired of dissolving the bayer so I just take the pills but you've caught my attention with this cocktail. What's the rationale behind baking soda, glycine, and sugar in the aspirin water? And is collagen an ok substitute for glycine in this context?

It protects the stomach against the aspirin's acidity, as well as aspirin's effect on glycine depletion.

Collagen is fine, but it tastes abhorrent.

 

[Such_Saturation]

Water retention is a side effect of Progest

 

[Squatrat]

Progesterone can cause fluid retention, swelling, and diarrhea if you get too much. It can also reduce bloating if the dose is right.

 

[Mito]

Why don't you try lower doses of progesterone and aspirin? Both will raise your temp. Try working your way up to 300-900 mg of aspirin before bed; it will greatly reduce depressive feelings. Make sure to dissolve in hot water, add baking soda, glycine, and sugar: cool and drink drink.

Do you do this each time you take aspirin or do you make a larger "batch" of dissolved aspirin water and divide the water in daily doses?

 

[Such_Saturation]

Progesterone can cause fluid retention, swelling, and diarrhea if you get too much. It can also reduce bloating if the dose is right.

What is the source of that?

 

[Squatrat]

WebMD, drugs.com, mayoclinic and a dozen other webpages that report on drugs. I got hit with all the sides they suggest.

 

[DaveFoster]

Do you do this each time you take aspirin or do you make a larger "batch" of dissolved aspirin water and divide the water in daily doses?

I do that every night about an hour before bed. I also take famotidine (20 mg) and K2 (4.5 mg).

 

[Mito]

I do that every night about an hour before bed. I also take famotidine (20 mg) and K2 (4.5 mg).

Is the famotidine to increase glycogen storage or additional protection against aspirin acidity?

 

[DaveFoster]

Is the famotidine to increase glycogen storage or additional protection against aspirin acidity?

It doesn't protect against aspirin's acidity directly. Aspirin reduces mucosal cell turnover through its inhibition of COX-1, while famotidine acts as an H2 blocker, which signals increased mucosal cell turnover in the GI tract, so it counters this effect.

 

[Constatine]

Progesterone can cause fluid retention, swelling, and diarrhea if you get too much. It can also reduce bloating if the dose is right.

What is the source of that?

Here is a good study of progesterone and estrogen on fluid retention: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849969/ . I personally think fluid retention is a more general stress response that is only loosely associated with estrogen (as estrogen is a stress hormone more or less).

 

[Such_Saturation]

Here is a good study of progesterone and estrogen on fluid retention: Sex Hormone Effects on Body Fluid Regulation . I personally think fluid retention is a more general stress response that is only loosely associated with estrogen (as estrogen is a stress hormone more or less).

Excuse me but it doesn't look like a super organized article... I only see the results for estradiol?

 

[sladerunner69]

A popular topic in some circles these days is that Pregnenolone largely converts to Allopregnenolone which may help alleviate depression as depressed people tend to have low tissue levels of Allopreg.

My Story: I am a relatively healthy 34 yr old male who is currently obese but maintains normal hormonal levels through hormonal supplementation; I can prove this with blood tests. I have a history of mental illness, largely Social Anxiety, Generalized Anxiety, and Clinical Depression.

After reading threads on this forum as well as Peat and some scientific studies it occured to me to try and mega-dose Pregnelonlone for its conversion into Allopreg. Some studies were using very high doses, as high as 400mg at a time so for some reason I got it into my head to take about 300mg of Pregenenolone a day.

At first things were fine but then I started to noticed tiredness, increased hunger, lethargy, and towards the end of the experiment I nearly had a mental breakdown. Some of you already know the answer why but I had to learn the hard way.

What I didnt know at the time is that Pregnenolone converts roughly 80% into Progesterone and then that Progest largely converts to Allopreg at at a rate of 70%. Why the math? Lets do some numbers: I was taking 300mg Preg per day s0 300x.8x.3=72mg. Thats a whopping 72mg of Progesterone I was taking everyday and a youngish man should not be taking anywhere near that amount.

My mother who lives in the same city as me was the first to catch on that something was wrong; she said I looked "sick and bloated". Water retention is a side effect of Progest so it figures. Here are the other side effects to watch out for: Bloating; breast tenderness; diarrhea; dizziness; drowsiness; fluid retention; headache; irritability; mild hair loss; muscle pain; nausea; spotting or breakthrough bleeding; stomach pain or cramping; tiredness; vomiting.

Its common knowledge to some on this forum, but unfortunately not to me, that high doses of Progest are anti-anabolic. The main reason being is Progest fights with DHT for access to DHT receptor sites. Too much Progest and too little DHT led to me becoming what Ill call "Progesterone Dominant."

Theres more I could add but im sure some of you familiar with these hormones can guess the story: I made myself anti-anabolic and sabotaged myself inadverdently.

TL;DR: Mega-dosing Pregnenolone for Allopreg is a bad idea. Dosing must be kept low and symptoms must be kept in check. If doctors find some way to directly increase tissue levels of Allopreg that would be great but mega-dosing Pregnenolone is not the ideal solution. Currently im off the Preg and mega-dosing DHT-boosting chemicals to get myself straight again. For men I recommend DHT-boosting drugs as the best way of installing mental calmness and clarity. That is all.

Im very itnerested in hearing if you ahd any adverse effects/symptoms, mainly speaking of the problem I have with higher dose preg which is derealization/ difficulty concentrating. Do you ever experience an intense spaced out feeling that makes it very difficult to be comfortable?

 

[Jane eagle]

Yeah preg can be problematic. The symptoms you describe seem more like estrogen than progesterone. You mentioned other hormones to stabilize your lab results and dht boosters. What exactly are you taking?

Salt can be great for anxiety and depression. Put a teaspoon of salt in a gallon of oj and work your way up to a glass twice a day.

Hello can you tell me is pregnenolone 100 milligrams a day would cause feet problems cracking splitting hard looking calluses that then crack and split