Why Does Low Dose Pregnenolone Affect Me So Powerfully?

Discussion in 'Pregnenolone' started by DavidGardner, May 20, 2020.

  1. DavidGardner

    DavidGardner Member

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    I have always noticed DHT-like effects from 10 - 20 mg of pregnenolone. Increased strength even without muscle gains, increased hair shedding, lower voice, and dramatically increased libido. 30 mg causes too much sedation, so I have never taken more than this. Even 10 - 20 mg taken three nights in a row has given me a benzodiazepine feeling the next morning, so I have only ever been able to take it two consecutive nights. I want to try again and see if this still holds true.

    I have seen that it converts mostly into progesterone and from there into allopregnanolone, but could some of it be converting down the line into DHT in my case? Or is the increased progesterone promoting conversion of testosterone down the 5-ar pathway instead of the aromatase pathway? Progesterone itself does not do anything for me except make me feel drugged even at a low dose, so I never take it anymore.
     
  2. Frankdee20

    Frankdee20 Member

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    Lower doses actually have different effects than higher ones... Pregnenalone is generally deemed unpredictable.... It can go DHEA or Progesterone route..... Mostly progesterone.... It can block or enhance certain neurotransmitters
     
  3. opethfeldt

    opethfeldt Member

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    At low doses, pregnenolone heavily converts to DHEA. This likely then converts to DHT and that would explain the androgenic effects.
     
  4. OP
    DavidGardner

    DavidGardner Member

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    So the progesterone conversion is greater at higher doses? If this is the case, low dose is more in line with what I want anyway.
     
  5. jamies33

    jamies33 Member

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    Ray talked about pregnenolone a lot w/ Timpone a few days ago. It's a tonic that normalizes cortisol, akin to ginseng, in regular doses and normalizes estrogen in larger, progesterone-promoting doses. He said he noticed no difference between 4 grams and 100mg eventually
     
  6. opethfeldt

    opethfeldt Member

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    Yeah, pregnenolone is very dose dependent in its effects. I wouldn't go any higher than 20mg if you desire the androgenic effects.
     
  7. Alpha

    Alpha Member

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    You mean 4mg?
     
  8. Markus

    Markus Member

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    No, it's actually 4 g :).
     
  9. Mossy

    Mossy Member

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    Could you share whether you take this topically or internally?
     
  10. OP
    DavidGardner

    DavidGardner Member

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    I take Pure Encapsulations orally. I was able to take it four consecutive nights last week without ill effect. I am on a lower dose of quetiapine than I have ever been on which seems to help. Quetiapine is such a powerful sedative that it is hard to handle anything even mildly sedating along with it. I actually think pregnenolone will help me to maintain this lower dosage. I am really hoping it will also help push my testosterone levels from the 500s to the 600s in conjunction with a lower PUFA intake than the previous year.
     
  11. TheBeard

    TheBeard Member

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    You guys are really in tune with your body.

    Even when I take me testosterone in the 3000s the libido increase is only subtle
     
  12. OP
    DavidGardner

    DavidGardner Member

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    :eek: !!!
     
  13. Mossy

    Mossy Member

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    Thanks for the detail.
     
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