Why Does Low Dose Pregnenolone Affect Me So Powerfully?

DavidGardner

Member
Joined
Jul 1, 2015
Messages
165
I have always noticed DHT-like effects from 10 - 20 mg of pregnenolone. Increased strength even without muscle gains, increased hair shedding, lower voice, and dramatically increased libido. 30 mg causes too much sedation, so I have never taken more than this. Even 10 - 20 mg taken three nights in a row has given me a benzodiazepine feeling the next morning, so I have only ever been able to take it two consecutive nights. I want to try again and see if this still holds true.

I have seen that it converts mostly into progesterone and from there into allopregnanolone, but could some of it be converting down the line into DHT in my case? Or is the increased progesterone promoting conversion of testosterone down the 5-ar pathway instead of the aromatase pathway? Progesterone itself does not do anything for me except make me feel drugged even at a low dose, so I never take it anymore.
 

Frankdee20

Member
Joined
Jul 13, 2017
Messages
3,296
Location
Sun Coast, USA
I have always noticed DHT-like effects from 10 - 20 mg of pregnenolone. Increased strength even without muscle gains, increased hair shedding, lower voice, and dramatically increased libido. 30 mg causes too much sedation, so I have never taken more than this. Even 10 - 20 mg taken three nights in a row has given me a benzodiazepine feeling the next morning, so I have only ever been able to take it two consecutive nights. I want to try again and see if this still holds true.

I have seen that it converts mostly into progesterone and from there into allopregnanolone, but could some of it be converting down the line into DHT in my case? Or is the increased progesterone promoting conversion of testosterone down the 5-ar pathway instead of the aromatase pathway? Progesterone itself does not do anything for me except make me feel drugged even at a low dose, so I never take it anymore.


Lower doses actually have different effects than higher ones... Pregnenalone is generally deemed unpredictable.... It can go DHEA or Progesterone route..... Mostly progesterone.... It can block or enhance certain neurotransmitters
 

opethfeldt

Member
Joined
Mar 12, 2017
Messages
490
At low doses, pregnenolone heavily converts to DHEA. This likely then converts to DHT and that would explain the androgenic effects.
 

DavidGardner

Member
Thread starter
Joined
Jul 1, 2015
Messages
165
At low doses, pregnenolone heavily converts to DHEA. This likely then converts to DHT and that would explain the androgenic effects.

So the progesterone conversion is greater at higher doses? If this is the case, low dose is more in line with what I want anyway.
 

jamies33

Member
Joined
Nov 14, 2017
Messages
1,484
Location
Canada
Ray talked about pregnenolone a lot w/ Timpone a few days ago. It's a tonic that normalizes cortisol, akin to ginseng, in regular doses and normalizes estrogen in larger, progesterone-promoting doses. He said he noticed no difference between 4 grams and 100mg eventually
 

opethfeldt

Member
Joined
Mar 12, 2017
Messages
490
So the progesterone conversion is greater at higher doses? If this is the case, low dose is more in line with what I want anyway.
Yeah, pregnenolone is very dose dependent in its effects. I wouldn't go any higher than 20mg if you desire the androgenic effects.
 

Alpha

Member
Joined
Nov 16, 2018
Messages
114
Ray talked about pregnenolone a lot w/ Timpone a few days ago. It's a tonic that normalizes cortisol, akin to ginseng, in regular doses and normalizes estrogen in larger, progesterone-promoting doses. He said he noticed no difference between 4 grams and 100mg eventually

You mean 4mg?
 

Mossy

Member
Joined
Jun 2, 2017
Messages
1,059
I have always noticed DHT-like effects from 10 - 20 mg of pregnenolone. Increased strength even without muscle gains, increased hair shedding, lower voice, and dramatically increased libido. 30 mg causes too much sedation, so I have never taken more than this. Even 10 - 20 mg taken three nights in a row has given me a benzodiazepine feeling the next morning, so I have only ever been able to take it two consecutive nights. I want to try again and see if this still holds true.

I have seen that it converts mostly into progesterone and from there into allopregnanolone, but could some of it be converting down the line into DHT in my case? Or is the increased progesterone promoting conversion of testosterone down the 5-ar pathway instead of the aromatase pathway? Progesterone itself does not do anything for me except make me feel drugged even at a low dose, so I never take it anymore.
Could you share whether you take this topically or internally?
 

DavidGardner

Member
Thread starter
Joined
Jul 1, 2015
Messages
165
I take Pure Encapsulations orally. I was able to take it four consecutive nights last week without ill effect. I am on a lower dose of quetiapine than I have ever been on which seems to help. Quetiapine is such a powerful sedative that it is hard to handle anything even mildly sedating along with it. I actually think pregnenolone will help me to maintain this lower dosage. I am really hoping it will also help push my testosterone levels from the 500s to the 600s in conjunction with a lower PUFA intake than the previous year.
 

TheBeard

Member
Joined
May 16, 2018
Messages
2,015
I have always noticed DHT-like effects from 10 - 20 mg of pregnenolone. Increased strength even without muscle gains, increased hair shedding, lower voice, and dramatically increased libido. 30 mg causes too much sedation, so I have never taken more than this. Even 10 - 20 mg taken three nights in a row has given me a benzodiazepine feeling the next morning, so I have only ever been able to take it two consecutive nights. I want to try again and see if this still holds true.

I have seen that it converts mostly into progesterone and from there into allopregnanolone, but could some of it be converting down the line into DHT in my case? Or is the increased progesterone promoting conversion of testosterone down the 5-ar pathway instead of the aromatase pathway? Progesterone itself does not do anything for me except make me feel drugged even at a low dose, so I never take it anymore.

You guys are really in tune with your body.

Even when I take me testosterone in the 3000s the libido increase is only subtle
 

Mossy

Member
Joined
Jun 2, 2017
Messages
1,059
I take Pure Encapsulations orally. I was able to take it four consecutive nights last week without ill effect. I am on a lower dose of quetiapine than I have ever been on which seems to help. Quetiapine is such a powerful sedative that it is hard to handle anything even mildly sedating along with it. I actually think pregnenolone will help me to maintain this lower dosage. I am really hoping it will also help push my testosterone levels from the 500s to the 600s in conjunction with a lower PUFA intake than the previous year.
Thanks for the detail.
 

Jing

Member
Joined
Feb 18, 2018
Messages
1,700
You guys are really in tune with your body.

Even when I take me testosterone in the 3000s the libido increase is only subtle
Same here most supplements , hormones anything else hardly notice much from them.
 

Korven

Member
Joined
May 4, 2019
Messages
324
Pregnenolone is the only supplement I can actually feel "doing something" (except for maybe magnesium glycinate).

It just makes everything better, instantly feel warmer and get very relaxed, better mood and stress resilience, sometimes I get a bit drowsy but sometimes I get energized. I think my beard is growing in faster as well which is nice. I wish I hadn't been so cautious before with taking safe steroids/hormones such as preg, it can be a very valuable tool for getting out of a chronically stressed state.
 
Similar threads
Thread starter Title Forum Replies Date
B Anti-Peat Low Carb Eating Does Not Cause Hypothyroid Debate - Anti-Peat 56
J Why Does Peat Say Beef Is Low PUFA? Studies Are Contrary. I Don't Get It Meat 6
Gadreel Why Does Tamoxifen Seem To Cause Low Libido And E.D Ask For Help or Advice 36
A Does Low Cortisol Leads To High Serotonin? (linked To My Situation) Ask For Help or Advice 7
O Does Low Fat Heal Acid Reflux? Digestion 2
K What Does It Mean When Your Body Feels Like It Got Hit By A Car After Low Carb For 2 Days? Ask For Help or Advice 3
Spartan300 What Does It Mean When NDT Lowers Already Low Temps & Mood? Health 9
D CICO. Does It Really Matter In A Low-fat/VLF Diet. Weigh In With Your Opinion Metabolism 6
A WHAT DOES LOW CHOLESTEROL MEAN? Cholesterol 2
R Does A Low Fat Diet Lower Androgens? Study Scientific Studies 1
D Aromatase Inhibitors (pharmaceutical) & What Does Very Low Estrogen Feel Like? Ask For Help or Advice 23
milk_lover Aspirin - does it help convert T4 to T3? Possible soln. to those with normal T4 but low T3? Aspirin 1
M Does Low Heart Rate Really Indicate A Problem Heart, Heart Rate, Blood Pressure 56
Kasra Does A Low-Fat Diet Lower Free Fatty Acids? Macros & Micros 8
M Crazy question, but does putting the finger in the throat to induce gagging , not vommitting, increase stomach acid? Ask For Help or Advice 1
yerrag When Inflammation Does Not Get Confirmed By Certain Markers of Inflammation Cancer, Degenerative Diseases 29
M Does taurine increase stomach acid or not? Ask For Help or Advice 3
K Why does vitamin K2 mk4 make my skin dry? K 4
S Why does Ask For Help or Advice 2
A Does vitamin K supplementation deplete vitamin E? Vitamins 25
bzmazu Vaccine: Twenty countries suspend injections; does that make you “hesitant?” Viruses, Parasites, Fungus, Vaccines 104
P Why does l dopa make me pee so much? Supplements, Pharmaceutical Drugs 4
ecstatichamster Aspirin increases cancer and mortality — or does it? Scientific Studies 9
ScurveDream Should friendship be forced? How exactly does "friendship" or "having friends" work across different parameters? Ask For Help or Advice 13
M Does cooking vegetables destroy their vitamin C? Ask For Help or Advice 11
V Does it have to be orange juice? Diet 36
F Why does Sildenafil and other PDE5 inhibitors help my sleep? Male Issues 0
D Does B-50 cause anhedonia? Water-Soluble Vitamins 29
yerrag Does Anyone Have References that Validate the Use of Urine pH as a Proxy for Blood/ECF pH? Acidity vs. Alkalinity 65
A Penis Does Not Get Quite As Hard As It Used To Ask For Help or Advice 35
Hgreen56 Does milk or calcium raise gaba? Milk 2
Sam321 Does speed of magnesium spray absorption correlate current levels of magnesium in system? Ask For Help or Advice 0
M Does magnesium glycinate increase dht? Supplements, Pharmaceutical Drugs 8
ScurveDream Leanness and physiology -- how does it all work (more of a rant)? Metabolism 1
lvysaur Does chicken digest faster than beef? Meat 4
deliciousfruit Does liver from grain-fed animals contain vitamin A? Meat, Organ Meat, Gelatin, Seafood 2
J How does Ray Peat make coffee? Ask For Help or Advice 8
U What does eggs offer to be important part of the diet? Diet 9
T Does adrenaline damage the nervous system? Ask For Help or Advice 3
L Does a Moderna vaccinated person cause harm to a non vaccinated person? Vaccines 15
BearWithMe Does NDT supplement, T3/T4 or iodine raise PTH? Natural Dessicated Thyroid 4
ddjd why does saturated fat + carbs make me fat?? Ask For Help or Advice 67
Hgreen56 Does Gaba decrease metabolic rate? Diet 0
P Why Does Lowering Estrogen Slow My Hair Loss? (Interesting experience) Hair & Nails 4
Lokzo Does Lion's Mane Destroy Your Libido/Sex Drive?! Supplements, Pharmaceutical Drugs 9
Frankdee20 Does dietary cholesterol intake increase it ? Cholesterol 8
ursidae >70 g of PUFA a day | Does diet even matter? Diet 72
TypicalJock Does food in plastic packaging effect the food? Ask For Help or Advice 1
tankasnowgod Milk, OJ, Cottage Cheese, Yogurt..... Does Temperature of these foods matter? Digestion 36
C Does Flowers Of Sulphur Only Benefit The Gut? Ask For Help or Advice 14

Similar threads

Top