Presumably your product is not metabolized by N-acetylation since it does not have an amino group?
None of them really get metabolized much, neither adamantane nor its derivatives.
The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives
"...In addition, the rigid hydrocarbon protects functional groups in its proximity from metabolic cleavage, enhancing duration of action of, amongst others, peptide-derived drugs. On the other hand, it is “biocompatible”, as metabolism can take place in the liver, so that toxic effects by accumulation upon chronic treatment are not to be expected. Most adamantane-based drugs for which metabolites have been studied are, in fact, being excreted largely unmodified, which has the added benefit that possible side effects arising from bioactive metabolites are intrinsically improbable."
The review on liphophilicity and adamantane derivatives posted in the original post has a section on metabolism where it says that the adamantane cage is excreted in changed.
"...What happens to the adamantane-derived pharmaceuticals once they have been administered? In this final chapter, we will briefly discuss metabolic degradation of some drugs incorporating adamantane as a building block. In mice, most of the amantadine dose given has been found to be excreted unchanged with urine within 12 hours after oral application.848 About 2% of the drug can be found in feces, so there is good oral absorption. Some metabolism does occur as still part of the dose cannot be collected in the animal's urine and feces. In rats, recovery of amantadine was lower; likewise, in dogs only 19% of the drug could be recovered from urine. N-methylation occurs in dog, as in this species, ~10% of the excreted amantadine is actually metabolized to 213 (Scheme 61). In monkeys, the half-life of the drug is ~5 h, and some metabolic conversions do also occur. This report also stated that in man ~86% of the drug can be recovered from urine, and there was no evidence of acylated, methylated, or otherwise modified amantadine metabolites in any of the urine samples from humans that were analyzed by GLC."
"...However, after analyzing samples from an individual attempting suicide by taking very large amounts of the drug indicating that metabolic conversions do occur in humans, the metabolism of amantadine under therapeutic dose regimens was revisited.849 When taking 200 mg orally, still the vast majority of amantadine (65–85%) can be detected in urine. The major metabolite in urine was acetylated 432, 5–15% were found in urine. A total of eight metabolites could be identified; all of which incorporated an unmodified adamantane moiety."
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