Vinero
Member
How does this compare to Memantine dosage wise? Let's say we have 40 mg of Memantine, is this equal in strength to 40 mg of Adamantane??
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@haidut yes some guidelines for memantine use vis a vis Adamantane use would be helpfulHow does this compare to Memantine dosage wise? Let's say we have 40 mg of Memantine, is this equal in strength to 40 mg of Adamantane??
I'll check it out. However if that kind of inner ear dysfunction disrupts balance it's probably not my issue - my balance is quite good. That said, I have a friend who had life-changing results from a frenectomy - fixing a "tongue tie". Apparently if even a minor tongue tie is untreated it can have huge repercussions with everything from balance to social behavior. I'm mentioning that because, seemingly unimportant issues (like inner ear stuff) can have significant compounded impacts into adulthood.
In the latest KMUD interview (KMUD: 3-17-17 Endocrinology (Part 1): Parkinson's) at the 38 minute mark, Ray talks about Memantine and Amantadine in the context of an alternative treatment for Parkinson's rather than dompamine drugs or L-Dopa which have detrimental side effects long term. He said Memantine and Amantadine are beneficial for their anti-excitatory effects on the cholinergic and glutamatergic systems. He also said they lower exposure to nitric oxide (NO) because the glutamate system ends up producing NO which suppresses mitochondrial respiration and energy production. He concludes that Memantine and Amantadine are restoring the energy process by reducing the effects of stress in a systematic way.Awesome, thanks! It would be nice if he does a newsletter or a radio show on adamantane and its derivatives. I think there are one of the most versatile substance in our possession as they oppose most of the mediators of the stress reaction he has been writing about - cortisol, prolactin, serotonin, acetylcholine, glutamate, viruses, bacteria, etc.
@haidut does it potentially lead to weight gain like cyproheptadine?
Can you show me specifically where in, for example, the study on HDAC inhibition (doi: 10.1016/j.bmcl.2013.03.002) the HDAC inhibition activity of unsubstituted adamantane (C10H16) is compared to the HDAC inhibition activity of substituted derivatives of adamantane?
How does this compare to Memantine dosage wise? Let's say we have 40 mg of Memantine, is this equal in strength to 40 mg of Adamantane??
@haidut yes some guidelines for memantine use vis a vis Adamantane use would be helpful
In the latest KMUD interview (KMUD: 3-17-17 Endocrinology (Part 1): Parkinson's) at the 38 minute mark, Ray talks about Memantine and Amantadine in the context of an alternative treatment for Parkinson's rather than dompamine drugs or L-Dopa which have detrimental side effects long term. He said Memantine and Amantadine are beneficial for their anti-excitatory effects on the cholinergic and glutamatergic systems. He also said they lower exposure to nitric oxide (NO) because the glutamate system ends up producing NO which suppresses mitochondrial respiration and energy production. He concludes that Memantine and Amantadine are restoring the energy process by reducing the effects of stress in a systematic way.
OK so I tried this on a mammalian subject. 20 drops last night, sublingual and then swallowed. Not much was reported except for a minty taste.
The next morning another 20 drops were tried, with the intention of doing 20 drops each morning from then out. Lots of adrenaline with body rushes and loose stools. A lot of salt, sugar, and water calmed that down. But soon after the subject started to notice incredible energy. There was a very strong desire to work out, like never before. There was some manual labor at work, and his endurance was way up, though he did get out of breath.
Still an early report, but the subject is going to do a much lower dose next time (maybe 1 drop) and work on bag breathing and increased salt consumption before getting back up to a dose that might replace Cyproheptadine or some of the other supplements he's taking.
Does anyone think this would pair with cypro well for reducing stress as well as pushing up dopamine? Been having great success with cypro but it leaves me feeling a little flat at times which I attribute to dopamine levels being low.
It may be too much of an anti-cholinergic effect when taken together. I think adamantane is best used on its own, at least until the proper dose is gauged. It should be anti-serotonin by itself so maybe not much need to add another serotonin blocker like cypro.
Thanks for the report. I personally do not use more than 10mg at once and repeat if needed a few times daily. I really like the sleep effects from 10mg before bed as at the lower dose it should be primarily anti-excitotoxic and anti-cortisol and so much dopaminergic and and simulating enough to disrupt sleep.
It may be too much of an anti-cholinergic effect when taken together. I think adamantane is best used on its own, at least until the proper dose is gauged. It should be anti-serotonin by itself so maybe not much need to add another serotonin blocker like cypro.
Yes, here it is. Not only was adamantane extremely potent HDAC inhibitor by itself but messing with its structure reduced that activity and its anti-cancer effects.
"...Initially we started our SAR studies with unsubstituted adamantane, (compound 5) which shows the HDAC inhibitory activity about 70 nM with 0.5-2.8 µM range of anti-cancer activity. Replacing hydrogen in 3rd position of 5 with ethoxy, methoxy, hydroxyl, phenyl and hydroxymethyl (compounds 6, 7, 8, 9 & 10), decreased the potency against HDAC as compared to 5 by 3 fold and the anti-cancer activity also reduced."
If you look at Table 1, compound 5 is the following:
View attachment 4878
Clearly not an unsubstituted adamantane (C10H16). 'Unsubstituted' in the context of the paper means only mono-substituted (The N-hydroxy 4-aminomethylcinamide (or similar) replacing a hydrogen). 'Substituted' (in the context of the paper) means di-substituted on the adamantane moiety.
Where in the paper is the HDAC inhibition activity of unsubstituted adamantane (C10H16) measured?