Prednisone or dexamethasone are generally preffered.
How would this result in changes to my cortisol/ACTH after an acute dose? Will it cause the "snap back" effect that I get from Cypro?
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Prednisone or dexamethasone are generally preffered.
Serotonin syndrome as I did on SJW
Does cyproheptadine use vitamin E?
Not specifically. Cypro inhibits lipid peroxidation and lowers ROS, so if anything, it would spare vitamin E.
Not specifically. Cypro inhibits lipid peroxidation and lowers ROS, so if anything, it would spare vitamin E.
Hi all, do you think Cyproheptadine will be effective in reversing cortisol resistance/downregulation of cortisol receptors?, i suffer from insomnia caused by chronic stress.
As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:
1. Cyproheptadine may have strong anti-cancer properties:
Unexpected remission of hepatocellular carcinoma (HCC) with lung metastasis to the combination therapy of thalidomide and cyproheptadine: report of... - PubMed - NCBI
Cyproheptadine displays preclinical activity in myeloma and leukemia. - PubMed - NCBI
2. Cyproheptadine may treat autism:
Cyproheptadine in the treatment of autistic disorder: a double-blind placebo-controlled trial. - PubMed - NCBI
Cyproheptadine in treatment of autism. - PubMed - NCBI
3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia. - PubMed - NCBI
Cyproheptadine in treatment of chronic schizophrenia: a double-blind, placebo-controlled study. - PubMed - NCBI
4. Cyproheptadine may treat depression and other similar mental issues:
Treatment of depression with cyproheptadine. - PubMed - NCBI
Cyproheptadine for prevention of neuropsychiatric adverse effects of efavirenz: a randomized clinical trial. - PubMed - NCBI
Effect of cyproheptadine treatment on conditioned avoidance response in female rats. - PubMed - NCBI
5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study. - PubMed - NCBI
[Protective effects of cyproheptadine on myocardial reperfusion injury in isolated rat hearts]. - PubMed - NCBI
6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
Effects of cyproheptadine on TXB2 and 6-keto-PGF1 alpha plasma levels in rabbits with hemorrhagic shock. - PubMed - NCBI
Protective effect of cyproheptadine in a gerbil model of cerebral ischemia. - PubMed - NCBI
Cyproheptadine reduces or prevents ischemic central nervous system damage. - PubMed - NCBI
7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
Brain cholesterol and phospholipid levels in cyproheptadine treated albino rats. - PubMed - NCBI
8. Cyproheptadine may protect from endotoxin:
Anti-endotoxic shock effects of cyproheptadine in rats. - PubMed - NCBI
Anti-shock effect of cyproheptadine in rabbit. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/8368073
9. Cyproheptadine may stimulate the immune system:
http://www.ncbi.nlm.nih.gov/pubmed/3567337
10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/2995088
11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
http://www.ncbi.nlm.nih.gov/pubmed/2994332
http://www.ncbi.nlm.nih.gov/pubmed/6109449
http://www.ncbi.nlm.nih.gov/pubmed/7017408
http://www.ncbi.nlm.nih.gov/pubmed/115197
http://www.ncbi.nlm.nih.gov/pubmed/4600047
http://www.ncbi.nlm.nih.gov/pubmed/177441
http://www.ncbi.nlm.nih.gov/pubmed/177112
http://www.ncbi.nlm.nih.gov/pubmed/1201741
http://www.ncbi.nlm.nih.gov/pubmed/180050
http://www.ncbi.nlm.nih.gov/pubmed/401824
12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
http://www.ncbi.nlm.nih.gov/pubmed/412631
http://www.ncbi.nlm.nih.gov/pubmed/508004
13. Cyproheptadine may be helpful in the treatment of "alcoholism":
http://www.ncbi.nlm.nih.gov/pubmed/3797491
http://www.ncbi.nlm.nih.gov/pubmed/14157085
14. Cyproheptadine may be helpful in the treatment of "psoriasis":
http://www.ncbi.nlm.nih.gov/pubmed/6735444
15. Cyproheptadine may be helpful in the treatment of decompression sickness:
http://www.ncbi.nlm.nih.gov/pubmed/7233624
16. Cyproheptadine may be helpful in restoring fertility in old age:
http://www.ncbi.nlm.nih.gov/pubmed/1204806
17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
http://www.ncbi.nlm.nih.gov/pubmed/4274414
I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.
Thoughts?
I took 0.5mg in the morning for 3days with no gloggy feeling and yesterday I took an another 0.5mg in the evening which gave me insomnia.
and this morning I took 0.5mg and been feeling gloggy,feeling pressure in the heart.
Would a week of say 4-6mg be safe for stomach inflammation without affecting dopamine levels too much? I intend on dropping my dose to .5 mg before I come off. Purchased the product last Friday and I have taken anywhere from 4-6mg before bed.
Thanks all!! I get the consensus that .5-2mg is safe
Keep eating as much (despite less hunger?) or more, if cypro slowed your metabolism to the point it was interfering with weight. Isn’t it obvious?@haidut , or whoever else may have a clear view on this point: how can someone retain the weight gain benefits after making a pause or quitting Cypro? How can one avoid loosing other gains as have happens to others in this thread?
Wonder if stopping Cypro just exposes you're bodies state without the drug or if it does something to raise cortisol drastically. As mentioned above, when i got off cypro i gained around 5-10 lbs from water- calories remained the same and i'm a big believer of calories in vs calories out so that doesn't make sense why i'd gain so much weight.