1. **NEW Mini Body Light** MBL1 - Orange & Red Light Therapy Mini Body Light
    CLICK HERE!
    Dismiss Notice
  2. Cholesterol Powder
    CLICK HERE!
    Dismiss Notice
  3. Pau D'arco Bark
    CLICK HERE!
    Dismiss Notice
  4. Metabasoap - Handcrafted Soap
    CLICK HERE!
    Dismiss Notice
  5. Cocoa Butter - Organic & Fair Trade Certified
    CLICK HERE!
    Dismiss Notice
  6. Charcoal Soap - For Deep Cleansing
    CLICK HERE!
    Dismiss Notice
  7. Orange & Red Light Therapy Device - LGS1
    CLICK HERE!
    Dismiss Notice
  8. Cascara Sagrada Powder From Farmalabor In Italy
    CLICK HERE!
    Dismiss Notice

The Dark Side Of Serotonin Exposed By Haidut In 70 Studies

Discussion in 'Scientific Studies' started by Mufasa, Oct 16, 2018.

  1. cdg

    cdg Member

    Joined:
    Dec 3, 2015
    Messages:
    125
    Many thanks for this Mufasa. Is there a thread like this on for PUFAs?
     
  2. Mateo Wiechers

    Mateo Wiechers Member

    Joined:
    Sep 26, 2018
    Messages:
    20
    Gender:
    Male
    Hi there,
    i have noticed that when i eat a Protein Rich meal, my depression tends to dissapear. I think this is because the Tryptophan/LNAA ratio decreases and that creates a temporary Tryptophan depletion in the brain. But i was wondering if also the TPH1 enzyme in the brain could be elevated by estrogen or other stress mediators since i appear to be very sensitive to Serotonin effects, especially on mood?.
     
  3. Mito

    Mito Member

    Joined:
    Dec 10, 2016
    Messages:
    1,263
  4. cdg

    cdg Member

    Joined:
    Dec 3, 2015
    Messages:
    125
  5. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    15,417
    Gender:
    Male
    Location:
    USA / Europe
    Yes, estrogen, histamine, cortisol, NO, prostaglandins, leukotrienes, etc all increase TPH activity and not just in the brain but systemically. That is one of the reasons depression is so highly correlated with inflammation and chemicals like aspirin help.
     
  6. Peatogenic

    Peatogenic Member

    Joined:
    Sep 11, 2017
    Messages:
    287
    Gender:
    Male
    This is great, thank you. Isn't it true that lowering estrogen automatically lowers serotonin?
     
  7. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    15,417
    Gender:
    Male
    Location:
    USA / Europe
    I would not say automatically, but since estrogen increases activity of TPH and thus serotonin synthesis, lowering estrogen would have the opposite effects generally.
     
  8. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    2,598
    inhibiting TH (i.e. reducing dopamine) abolishes fatigue???
     
Loading...