Scalp Progesterone For Hair Loss Experiment

[Arrade]

Wow that soon? If not this summer, then for sure next year?

Any idea how it will be distributed/available? Script only? Order online?

They finished stabilizing the lotion last year, and Brotzu presented at sitri in April. Brotzu Jr thinks July is the deadline.
Not too sure about availability, but as a cosmetic I’d think it would be easy to get

 

[xetawaves]

It's weird man..

I've used Prog for over a year now, and I'm still not sure if it works or not. OR if it may be making things worse.

I think for me, cutting out stimulants is big. PERHAPS I will visit NDT (thyroid).

Ideally I need to go to a doctor and get my thyroid levels checked, ferritin, test, etc.

WHEN IS BROTZU LOTION COMING OUT?

Seti is coming out soon'ish as well (PDG2 angle).

There's stuff coming out that isn't related to anti-androgens.

Now... I'm also wondering.... with prog...

Since it metabolizes different in the liver, and that guy has big success with Oral Prog (powder).

We should try to get that as well. We can goto the doc and request it...

Use it EOD like he does.

ALSO, they say only 10% or so gets absorbed when using those 100mg pills... which means, theoretically, he should be getting only 10mg of prog?!? So perhaps we need to look at dosing 10mg or so.

I know in some posts online.. usually when guys say they are getting regrowth, I remember seeing 10mg used and whatnot (if using cream) so not huge dosages.

Perhaps we're using too much.

I've been having the same thoughts in regards to maybe using too much. I've considered lowering the dose and seeing what happens. I started out on low dose progesterone back in dec-jan and it felt like my androgens skyrocketed. Super high libido and oily skin. Although I may revisit a lower dose because I've changed my diet and supplement regimen since then. Maybe it'll have a different affect. I do feel like progesterone has helped me maintain my hair for the past 5 months.

Brotzu should be out by the end of summer. It's being marketed as a cosmetic compound so it won't need to pass through trials. It apparently works very well in young people. Seti is an option if you have an extra 500 bucks a month to spend lol


So I took a picture to help document any progress. This is my hair after blowdrying it and in bright lighting. There's also no toppik in it. I always spray a bit of toppik in the hairline, it helps a lot. My norwood 3 and all its glory.
What you guys think? Could I rock a buzzcut? I'm so close to just doing it.

Imgur

 

[Arrade]

I've been having the same thoughts in regards to maybe using too much. I've considered lowering the dose and seeing what happens. I started out on low dose progesterone back in dec-jan and it felt like my androgens skyrocketed. Super high libido and oily skin. Although I may revisit a lower dose because I've changed my diet and supplement regimen since then. Maybe it'll have a different affect. I do feel like progesterone has helped me maintain my hair for the past 5 months.

Brotzu should be out by the end of summer. It's being marketed as a cosmetic compound so it won't need to pass through trials. It apparently works very well in young people. Seti is an option if you have an extra 500 bucks a month to spend lol


So I took a picture to help document any progress. This is my hair after blowdrying it and in bright lighting. There's also no toppik in it. I always spray a bit of toppik in the hairline, it helps a lot. My norwood 3 and all its glory.
What you guys think? Could I rock a buzzcut? I'm so close to just doing it.

Imgur

You handsome mofo. TBH i would keep what you have
Also seti is a drug and probably has sides, it’s not even released yet
It would be cheaper to make your own Brotzu lotion, you can check out
Regrowbros.com for more info

 

[xetawaves]

You handsome mofo. TBH i would keep what you have
Also seti is a drug and probably has sides, it’s not even released yet
It would be cheaper to make your own Brotzu lotion, you can check out
Regrowbros.com for more info

haha thanks man. But yea, if my hairline gets any worse then I'll end up buzzing it. Gonna hold off for now though. Half of me wants to buzz it and get back into bodybuilding hardcore and the other half wants to hold on and see what happens with my regimen. At the same time though, I wanna dermaroll with brotzu lotion and that's a lot easier with a buzzcut. I'd also like to try soaking my scalp in apple cider vinegar a couple times a week to help reverse calcification.

 

[Arrade]

haha thanks man. But yea, if my hairline gets any worse then I'll end up buzzing it. Gonna hold off for now though. Half of me wants to buzz it and get back into bodybuilding hardcore and the other half wants to hold on and see what happens with my regimen. At the same time though, I wanna dermaroll with brotzu lotion and that's a lot easier with a buzzcut. I'd also like to try soaking my scalp in apple cider vinegar a couple times a week to help reverse calcification.

The acv kinda softest up my scalp and kills any itch. I’m only a week in.
The Brotzu lotion has liposomes, I’ll prbably get a dermapen but just for the growth factors

 

[Arrade]

I need to follow @Elephanto ‘s suggestions with the post meal coconut oil, not much more to adopt from his regime
I’m pretty confident mine is just a blood flow problem because my bald temples have long blonde hairs, thy just need more nutrients

 

[Arrade]

I’m also taking 45 mg mk4 for the androgen / jaw widening effect. It seems counter-intuitive with the spike of test, I can’t tell if it’s that or it’s helping my blood flow because I have shed Some.

 

[Progesterone]

I've been having the same thoughts in regards to maybe using too much. I've considered lowering the dose and seeing what happens. I started out on low dose progesterone back in dec-jan and it felt like my androgens skyrocketed. Super high libido and oily skin. Although I may revisit a lower dose because I've changed my diet and supplement regimen since then. Maybe it'll have a different affect. I do feel like progesterone has helped me maintain my hair for the past 5 months.

Brotzu should be out by the end of summer. It's being marketed as a cosmetic compound so it won't need to pass through trials. It apparently works very well in young people. Seti is an option if you have an extra 500 bucks a month to spend lol


So I took a picture to help document any progress. This is my hair after blowdrying it and in bright lighting. There's also no toppik in it. I always spray a bit of toppik in the hairline, it helps a lot. My norwood 3 and all its glory.
What you guys think? Could I rock a buzzcut? I'm so close to just doing it.

Imgur

You could rock anything you want... with jawline/cheek bones like that.

It may be more helpful to take a pic, from various angles. left side, right side, TOP of head, etc.

It seems you're only area of concern is your hairline though right?

Also, brushing hair up to expose hairline more, will help with seeing the progress over time, otherwise it will be harder to tell.

Seti is available as a research chem powder now, and has been for awhile (I've tried, stupidly) but I'm talking the legit stuff, that you can get from a doc.

Your hair looks pretty damn good as is right now, you're not close to needing to buzz it off lol, if you could just maintain....

 

[xetawaves]

I need to follow @Elephanto ‘s suggestions with the post meal coconut oil, not much more to adopt from his regime
I’m pretty confident mine is just a blood flow problem because my bald temples have long blonde hairs, thy just need more nutrients

Where my hairline has receded also has long blonde hairs. They've been there for forever and have never shed. It's weird as hell.

You could rock anything you want... with jawline/cheek bones like that.

It may be more helpful to take a pic, from various angles. left side, right side, TOP of head, etc.

It seems you're only area of concern is your hairline though right?

Also, brushing hair up to expose hairline more, will help with seeing the progress over time, otherwise it will be harder to tell.

Seti is available as a research chem powder now, and has been for awhile (I've tried, stupidly) but I'm talking the legit stuff, that you can get from a doc.

Your hair looks pretty damn good as is right now, you're not close to needing to buzz it off lol, if you could just maintain....

Thanks man. One of my friends told me that I'd be fine with no hair, he said I certainly had the face for it. It makes me feel a lot better about losing my hair, and I've came so close to just buzzing it so it'll be easier to apply different things to my scalp and experiment. It's a hard thing to actually bring myself to do though lol

Back to progesterone, I think I'm going to lower my dosage quite a bit and see what happens. I'm hesitant though because I didn't have much luck before. I feel like I was shedding a lot when I was only taking a few drops a day. I might give it another shot though. What dosage seems to work best for your hair?

 

[xetawaves]

Also, I came across this. This explains why I was experiencing enlarged prostate issues before taking progesterone.


THE DETAILED CAUSES OF MALE PATTERN BALDNESS AND PROSTATE GROWTH

Overview:

when systemic progesterone and systemic cortisol levels are too low, this causes too high DHT metabolism in hair follicles which in turn causes excess free radical damage to the hair follicles on our head in areas where the blood flow is restricted ("due to genetic predisposition"). The additional lack of blood flow to hair follicles means the free radical damage to hair follicles cannot be repaired adequately.

The same excess-free-radical-damage-due-to-excess-DHT-metabolism occurs in our prostate, inflaming our prostate causing either pain and / or constricting the urethra thus reducing urine flow.

This overview omits a lot of important details, so you MUST also read the following detailed explanation before discounting the above info.

Details:

Relatively high levels of progesterone are necessary to compete with DHT for DHT receptors. When progesterone triggers a DHT receptor, then DHT cannot trigger that receptor, and the progesterone which enters the cell triggers progesterone's actions not DHT's actions.

Relatively high levels of progesterone are necessary to upregulate the p53 tumor suppressor protein, which is postulated as one of the primary means of minimizing prostate tumors.

Relatively high levels of cortisol are necessary to oppose / downregulate DHT metabolism. Cortisol acts directly on our genes to limit the ability of T and DHT to trigger their own genetic effects.

When the cortisol-production-line hormones progesterone and cortisol are too downregulated, then cells will aromatase T into E2, and use the E2 to oppose T metabolism and DHT metabolism. To our cells, this is "Plan B". "Plan A" is to use progesterone and cortisol to oppose / downregulate T and DHT metabolism.

While using E2 to oppose T metabolism and DHT metabolism works well in cells which absorb DHT from serum, it works very poorly in cells which manufacture their own DHT (eg: prostate, and hair follicles, ie: all cells with plenty of 5? reductase). Hence these cells continue to experience too high DHT metabolism even in the presence of too high E2.

At the onset of male pattern baldness, our progesterone and our cortisol have gone too low, which would allow T metabolism and DHT metabolism to go too high, so our cells invoke their secondary defence mechanism and increase E2, and they then use E2 to oppose T metabolism and DHT metabolism.

When progesterone is relatively too low, this spells that all of the cortisol-production-line hormones (eg: preg, prog, cortisol) are downregulated to below optimum, and this is why the solution is to restore the optimal hormone levels in the cortisol-production-line.


HALTING AND POSSIBLY REVERSING MALE PATTERN BALDNESS
Addressing The Root Cause

Addressing the root cause requires boosting systemic progesterone (not necessarily by supplementating with progesterone) and boosting systemic cortisol (not necessarily by supplementing with HC, which is man made bioidentical cortisol), up to the level which balances systemic DHT metabolism.

Unfortunately for most males, boosting the cortisol-production-line also requires boosting thyroid hormones T3 and T4, because once the cortisol-production-line hormones are lowered, our cells automatically downregulate our T3 to match our reduced cortisol levels, which creates an excess of T4 (T3 is made from T4). When our hypothalamus detects excess T4, it downregulates the synthesis of T4 in the thyroid gland.

Unfortunately once our hypothalamus downregulates our T4, our body enters a very stable state with a reduced resting metabolic rate. When this occurs, boosting the cortisol-production-line hormones requires boosting our resting metabolic rate, and that requires a three phased solution approach, ie:

Phase 1: Restore preg, prog and cortisol, via supplementary transdermal pregnenolone (or prog), to as good as can be achieved without thyroid hormones.

Phase 2: Restore thyroid hormones, pref via supplementary slow-release-compounded T3 (not yet T4) and adjust both preg and T3 thyroid hormones together to achieve optimum balance as well as optimum levels of all cortisol-production-line hormones as well as optimum levels of thyroid hormones.

Phase 3: Swap out as much T3 with T4 as possible (definitely possible) and swap out as much pregnenolone with dietary cholesterol as possile (less effective with increasing age).

This is explained in Hormone Modulation Therapy 101 (HMT101) scroll down to "What process should my doctor follow...", and the details re pregnenolone supplementation are explained in Cortisol Boost 101 (CB101), scroll down to "Finding the pregnenolone and progesterone "top up" sweet spots". The details re thyroid hormone supplementation are explained in Thyroid Boost 101 (TB101), scroll down to "Dosing suggestions for T3-only, and T4-only".


HALTING AND POSSIBLY REVERSING MALE PATTERN BALDNESS
Leaving The Root Cause In Place By Reducing Hair Follicle DHT Metabolism

Option 1: Infra Red or Laser Thermal Treatment of Hair Follicles.

This increases the metabolic rate of the hair follicle cells, so they absorb more hormones including progesterone, and they allow the free radical damage to be repaired.

Option 2: Localized DHT Metabolism Reduction: Hair Follicles Only

Only Big Pharma drugs are available to achieve this, and the best of these are topical low concentration ketoconazole (eg: Nizoral) and spironolactone (eg: Aldactone)

Provided you keep the concentration low, then these do have mild systemic effects, however in many cases a small degree of systemic DHT suppression is required to help keep DHT metabolism in the prostate in check, and some people have discovered that ceasing their ketoconazole and / or spironolactone treatement results in mild prostate inflammation.

Option 3: Systemic Reduction Of DHT Metabolism: Only Use This If Systemic DHT Metabolism Is High

WARNINGS:
1) A little suppression of systemic DHT metabolism may reduce libido.
2) Too much suppression of systemic DHT metabolism will definitely reduce libido.
3) If your cortisol-production-line is too downregulated while you're undergoing systemic DHT suppression therapy, then this can "tip you over the edge" and strongly suppress your entire cortisol-production-line (the "finasteride effect"). This can happen after a week if your cortisol-production-line is too downregulated when you start systemic DHT suppression therapy, or it can occur after several years as aging will eventually downregulate your cortisol-production-line hormones over time.

How to measure systemic DHT metabolism is explained here (hint: 24 hr urinalysis of several specific metabolites is necessary):
http://musclechatroom.com/forum/show...36&postcount=4

The Big Pharma drugs available to specifically reduce DHT metabolism, without directly reacting with other hormones, are dutasteride (eg: Avodart) and finasteride (eg: Proscar, Propecia)

The natural substance isolates / extracts which specifically reduce DHT metabolism are saw palmetto (not sure if there are any others).

Of these three substances, low dose dutasteride (eg: Avodart) is able to be managed much more reliably than both finasteride and saw palmetto (more on this below), and when finasteride or saw palmetto are not managed adequately in some people, those people have experienced a severe crash of the cortisol-production-line hormones - and these people have formed self-help groups such as propeciahelp.com, mypropeciasideeffects.com, etc...

NB: all these people need to do is restore their cortisol-production-line hormones to optimum, but:
a) they don't understand what their cortisol-production-line hormones are,
b) they're prepared to undergo "quick fix" hormone modulation therapy using finasteride or saw palmetto, but they're usually not prepared to undergo the much slower but much more reliable process of boosting their cortisol-production-line hormones.


HALTING AND POSSIBLY REVERSING MALE PATTERN BALDNESS
Recovering Libido

The only option to maintain hair and recover libido is to boost the cortisol-production-line hormones (eg: preg, prog, cortisol) as much as possible, and in addition boost thyroid hormones T4 and T3 up to the limit imposed by the maximum cortisol levels.

Determining the max boost to the cortisol-production-line hormones and thyroid hormones as an iterative process (boost preg/prog/cortiso, then boost T4/T3, boost preg/prog/cortisol a little more, boost T4/T3 a little more, etc...) This will boost overall metabolism, which includes boosting systemic T and systemic DHT, yet the DHT metabolism boost within hair follicles and the prostate is kept manageable, ie: there is no excessive free radical damage to these tissues so hair follicles stay healthy and the prostate remains normal size.


WHAT SPECIFICALLY ABOUT FINASTERIDE AND SAW PALMETTO CAUSES THIS HORMONE CRASH ?

While finasteride (eg: Proscar, Propecia) lowers systemic DHT metabolism similar to dutasteride, the fact that the half life of finasteride is anywhere from 4 hours (in fast metabolizers) to as high as 12 hours (in slow metabolizers), which means the effective life of the finasteride or saw palmetto can be anywhere from 6 hours to 18 hours. This means that the amount of suppression / downregulation of DHT metabolism can be much greater than anticipated.

The problem with excessive DHT suppression / downregulation is that DHT triggers many of the same gene expression actions as T (not 100% overlap) and therefore suppression / downregulation of DHT results in downregulation of our testosterone metabolism.

Since one of progesterone's and cortisol's critical functions is to oppose T and DHT metabolism, therefore when T and DHT metabolism activity declines (includes genetic expression effects), then cells downregulate their cortisol and progesterone receptors and absorb less cortisol and less progesterone. This is because they need less "opposition" or "downregulation" of T and DHT.

The way the body achieves this negative feedback loop is by downregulating the entire cortisol-production-line (eg: preg, prog, cortisol). But once the cortisol-production-line hormones are lowered, our cells automatically downregulate our T3 to match our reduced cortisol levels, which creates an excess of T4 (T3 is made from T4). When our hypothalamus detects excess T4, it downregulates the synthesis of T4 in the thyroid gland.

Unfortunately once our hypothalamus downregulates our T4, our body enters a very stable state with a reduced resting metabolic rate. Once we've entered this very stable state with a lowered resting metabolic rate, most males who then back out their finasteride or saw palmetto can only recover their previous hormone levels (along with their previous high resting metabolic rate) very very slowly, and some will never recover their previous high hormone levels without intervention.

Once we've entered this very stable state with a lowered resting metabolic rate, the intervention required is to boost the cortisol-production-line hormones by boosting resting metabolic rate, and that requires the three phased solution approach, explained in the previous section "Addressing the root cause".


HOW DO I PREVENT MY HORMONES CRASHING WHEN SUPPRESSING DHT ?

While it's simple to explain at a high level, it's a complex process when implemented: You need to initially monitor your sex hormones and your cortisol-production-line hormones (eg: preg, prog, cortisol) and if these are too low initially then you will need to either abstain from using DHT suppressants / downregulators, or you must first optimize at least your cortisol-production-line hormones (eg: preg, prog, cortisol) until your E2 is lowered, before commencing to suppress DHT.

This process is described in the Cortisol boost 101 primer, and you can access that from the links in the Hormones 101 primer, which is a sticky on the front page of this AllThingsMale forum.


WHAT IF INCREASED SERUM PROGESTERONE DOESN'T REVERSE MALE PATTERN BALDNESS ?

That's usually because the progesterone isn't being absorbed by cells, which is usually because those cells have an overall metabolic rate which is too low.

Since the progesterone is synthesizing into some cortisol (just not enough) the reason for the too low metabolic rate in these cells is not due to inadequate cortisol. In this case it's due to inadequate thyroid hormone T4.

Once T4 levels are restored to optimum, the cells will absorb both the T4 (which gets enythesized into T3) and extra cortisol, and they will boost their overall metabolic rate to optimum, and that's when they'll start absorbing more progesterone.


WHY IS THE DHT METABOLISM IN MY HAIR FOLLICLES HIGH, YET I DONT HAVE EXCESSIVE LIBIDO, AND / OR MY ERECTION PERFORMANCE IS BELOW PAR ?

Since libido and erection performance are promoted by DHT which originates from cells which absorb DHT from serum (ie: not the prostate, not hair follicles), and since these cells are using relatively high E2 to oppose / downregulate their DHT metabolism, therefore the cells which promote libido and erection performance are doing a poor job of triggering adequate libido, and they're doing a poor job of triggering adequate erection performance.

When these cells use increased levels of progesterone and cortisol to oppose / downregulate T metabolism and DHT metabolism, then IF your thyroid hormone T4 levels rise to match the increase in your cortisol (more likely in younger males, less likely in older males), then your overall metabolic rate will increase, and this includes your systemic T and DHT metabolism but NOT your hair follicle or your prostate DHT metabolism ! Thus your libido and erection performance will remain unchanged, yet your hair will stay put, and your prostate will shrink to normal size.

HOWEVER (WARNING!) When these cells use increased levels of progesterone and cortisol to oppose / downregulate T metabolism and DHT metabolism, then IF your thyroid hormone T4 levels do not rise to match the increase in your cortisol (more likely in older males, less likely in younger males), then your overall metabolic rate will not increase, so your systemic T and DHT metabolism will not increase. Thus your libido and erection performance will decrease. In this case you must boost your thyroid hormones too. This is explained in the Thyroid boost 101 primer, which has a link in the Hormones 101 "sticky" on the first page of this AllThingsMale subforum.


PAPERS / REFERENCES

1) Confirmation of ability of progesterone to inhibit DHT in hair follicles:

Journal: European Journal of Dermatology. Volume 11, Number 3, 195-8, May - June 2001, Revues
Title: "Influence of estrogens on the androgen metabolism in different subunits of human hair follicles"
URL full text


2) Confirmation of cortisol's ability to downregulate T

Journal: JCEM
Title: Acute Suppression of Circulating Testosterone Levels by Cortisol in Men
URL abstract

and

Journal: Journal of Molecular Endocrinology, 41, 165-175.
Title: Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1
URL full text


3A) Confirmation that hair follicles which have their own 5? reductase absorb serum T to manufacture most of their own DHT.

Journal: Archives of Dermatological Research. 1998 Mar;290(3):126-32.
Title: 5 alpha-reductase activity in the human hair follicle concentrates in the dermal papilla.
URL abstract

3B) Corrolary: Since increasing cortisol downregulates T synthesis, therefore increasing cortisol also downregulates the synthesis of DHT within hair follicle cells.

That's because hair follicle cells don't absorb much DHT directly, but instead they absorb T from serum and synthesize that into DHT via the action of 5? reductase.


4A) Confirmation that upregulation of serum DHT levels follows upregulation of hair follicle DHT levels (not to the same extent):

I don't have an obvious demonstration of this.

4B) Confirmation that downregulation of serum DHT levels follows downregulation of hair follicle DHT levels (not to the same extent):

Journal: Journal of the American Academy of Dermatology Volume 55, Issue 6 , Pages 1014-1023, December 2006
Title: The importance of dual 5?-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride
URL abstract
URL detailed summary

4C) Assumption with high likelihood of being correct: Since the downregulation of serum DHT levels follows downregulation of hair follicle DHT levels (but not to the the same extent), that the upregulation of serum DHT levels follows downregulation of hair follicle DHT levels (but not to the the same extent).

While you might choose to be pedantic and dispute this assumption, if you rejected the hard fact that both progesterone and cortisol downregulate DHT in hair follicles, just because you chose to dispute this assumption, then you'd be throwing the baby out with the bathwater.


5A) Confirmation that E2 does not suppress DHT metabolism adequately in cells which manufacture their own DHT

[TO DO]


ACCURATE MONITORING OF DHT METABOLISM

Unfortunately serum DHT levels get high when DHT gets "backed up" and DHT is not being used up (ie: when DHT metabolism is low). This is quite unlike testosterone, which does not get "backed up" when T is not being used.

When DHT is being used up, more DHT needs to be synthesized, ie:
testosterone ---5? reductase---> DHT

Therefore any biomarker which can indicate the activity of 5? reductase enzymes also indicates the rate of synthesis of DHT from testosterone, and thus indicates DHT metabolism.

Via experimental research, several research teams have confirmed that the synthesis of tetrahydrocortisol ---5? reductase---> 5? tetrahydrocortisol (5?THF)

...can be monitored using 24hr urinary analysis, and the ratio of 5?THF to THF follows the 5? reductase activity, ie:

high ( 5?THF / THF ) shows high 5? reductase activity
low ( 5?THF / THF ) shows low 5? reductase activity

Taken together, these are good indicators of 5? reductase acitivity, and thus DHT metabolism. Dr Crisler seems to agree.

The following research teams confirmed that the ratio of 5?THF to THF follows the 5? reductase activity, and thus DHT metabolic activity, eg:

Title: Diagnosis of 5alpha-reductase 2 deficiency: a local experience
Journal:
Author(s):
URL Full Text

NB: 5a THF/THF normal ratio range is between 0.5 and 2.5 quoted in "Diagnosis of 5alpha-reductase 2 deficiency: a local experience".

Title: The Diagnosis of 5{alpha}-Reductase Deficiency in Infancy
Journal: blah
Author(s): blah
URL Full Text

Title: A Case of 5 alpha-reductase Deficiency in Infancy
Journal: blah
Author(s): blah
URL Full Text

Title: Early diagnosis and management of 5 alpha-reductase deficiency
Journal: blah
Author(s): blah
URL Full Text

Title: Increased 5{alpha}-Reductase Activity and Adrenocortical Drive in Women with Polycystic Ovary Syndrome
Journal: blah
Author(s): blah
URL Full Text


Copyright is retained by chilln, 2008, 2009, 2010, 2011

 

[xetawaves]

Would really like to get @haidut 's opinion on the information above.

 

[Hairlosssucks]

May be bs or not but I also think no fap helps. I heard chronic masturbation can affect your e2 and testosterone receptors also it causes a spike in prolactin. I definitely notice less sebum and shedding when I have gone in a week or 2.

I’ve heard in some people their shedding just stops when they no fap which is most likely bull crap but just as mental stress can be a stressor for hair maybe chronically addictive masturbation could.

 

[Progesterone]

Where my hairline has receded also has long blonde hairs. They've been there for forever and have never shed. It's weird as hell.



Thanks man. One of my friends told me that I'd be fine with no hair, he said I certainly had the face for it. It makes me feel a lot better about losing my hair, and I've came so close to just buzzing it so it'll be easier to apply different things to my scalp and experiment. It's a hard thing to actually bring myself to do though lol

Back to progesterone, I think I'm going to lower my dosage quite a bit and see what happens. I'm hesitant though because I didn't have much luck before. I feel like I was shedding a lot when I was only taking a few drops a day. I might give it another shot though. What dosage seems to work best for your hair?

I think 100mg, put into a Veggie capsule (more durable than gelatin) and swallowed, is a good bet. Once nightly, or EOD at night, if we want to copy that guy who stopped his loss and thickened up his hair. Perhaps the EOD part is important.

Putting 100mg in a capsule and swallowing is different than applying topically. I can personally tell the difference. Try an experiment if you don't believe me, 100mg applied topically to skin before bed. Then try 100mg put into a veggie capsule, before bed. After taking the capsule, you'll feel a bit different when you wakeup, sort of a mini hangover that doesn't last very long, lol. (at least when first starting on it).

We could also try 10mg placed into veggie capsule.

I think we should be using this orally, for our intended purpose.

 

[Progesterone]

Would really like to get @haidut 's opinion on the information above.

I've seen this before, on paper it sorta makes sense.

Also would love to see haidut's opinion.

@xetawaves if the above is true or somewhat true, we would just need to add TyroMax really... (for T4 boost, and possibly the safest T4 boost compared vs synthetic thyroid compounds).

EDIT: Re-read the article, so... need to boost T3 first... then T4, hmmm. Perhaps Tyronene, then Tyromax started after (which is high in t4 over t3)

EDIT 2: Gonna dose 1 drop of Tyronene today, shortly... will report later on. let's see what happens.

Speaking of which, do you think you have any thyroid issue? what are your temps usually?

 

[xetawaves]

I've seen this before, on paper it sorta makes sense.

Also would love to see haidut's opinion.

@xetawaves if the above is true or somewhat true, we would just need to add TyroMax really... (for T4 boost, and possibly the safest T4 boost compared vs synthetic thyroid compounds).

EDIT: Re-read the article, so... need to boost T3 first... then T4, hmmm. Perhaps Tyronene, then Tyromax started after (which is high in t4 over t3)

Speaking of which, do you think you have any thyroid issue? what are your temps usually?

The guy who originally posted that is/was a user on allthingsmale.com which is dr crisler's forum. His username is Chilln and he apparently had a lot of credibility there. I might order some t3 from idealabs and see what happens. If I do end up lowering my progesterone dosage then I'll probably stick with transdermal application. I think the body uses it more efficiently that way. I might just cut my dosage in half rather than go all the way down to 10mg.

I'm also going to start using red light on my scalp after taking progesterone.
"Option 1: Infra Red or Laser Thermal Treatment of Hair Follicles.

This increases the metabolic rate of the hair follicle cells, so they absorb more hormones including progesterone, and they allow the free radical damage to be repaired."

As far as my thyroid goes, I'm not sure. My mom had thyroid cancer so my grandma always tells me to pay close attention to it. I've never really had any tests done apart from a basic tsh that came back normal. That was around 10 years ago though. Can't we just boost t3 by increasing iodine intake?

 

[Progesterone]

The guy who originally posted that is/was a user on allthingsmale.com which is dr crisler's forum. His username is Chilln and he apparently had a lot of credibility there. I might order some t3 from idealabs and see what happens. If I do end up lowering my progesterone dosage then I'll probably stick with transdermal application. I think the body uses it more efficiently that way. I might just cut my dosage in half rather than go all the way down to 10mg.

I'm also going to start using red light on my scalp after taking progesterone.
"Option 1: Infra Red or Laser Thermal Treatment of Hair Follicles.

This increases the metabolic rate of the hair follicle cells, so they absorb more hormones including progesterone, and they allow the free radical damage to be repaired."

As far as my thyroid goes, I'm not sure. My mom had thyroid cancer so my grandma always tells me to pay close attention to it. I've never really had any tests done apart from a basic tsh that came back normal. That was around 10 years ago though. Can't we just boost t3 by increasing iodine intake?

Need to write a quick reply, but..

Yes, kelp pills are possible (iodine content) IMO.

I'm not gonna do T3 today (too many horror stories) and will do some Methylene blue.

Methylene Blue (MB) Mimics Thyroid - Boosts T4 , Lowers TSH

Man With Male Pattern Baldness Regrows Hair With Methylene Blue

 

[xetawaves]

Need to write a quick reply, but..

Yes, kelp pills are possible (iodine content) IMO.

I'm not gonna do T3 today (too many horror stories) and will do some Methylene blue.

Methylene Blue (MB) Mimics Thyroid - Boosts T4 , Lowers TSH

Man With Male Pattern Baldness Regrows Hair With Methylene Blue

Yes, I've seen that. He was taking a huge MB dose.

I wonder if anyone has ever tried MB alongside progesterone.

 

[Progesterone]

Yes, I've seen that. He was taking a huge MB dose.

I wonder if anyone has ever tried MB alongside progesterone.

Yesterday I took 500mcg MB post-workout, and 12mg of Prog placed into veggie capsule and swallowed at bedtime. MB provides a nice little subtle 'nootropic' feeling boost.

I still believe in prog. I have lost some ground it looks/feels like since stopping my steady dosage of 100mg oral prog nightly, and going back on/off it, since January (for sports).

I think my new regimen will be: 1mg MB daily (split into 500mcg+500mcg dosages, OR taken all at once) + 12mg oral prog consumed in veggie capsule.

+ @Joeyd Thoughts?

 

[xetawaves]

Yesterday I took 500mcg MB post-workout, and 12mg of Prog placed into veggie capsule and swallowed at bedtime. MB provides a nice little subtle 'nootropic' feeling boost.

I still believe in prog. I have lost some ground it looks/feels like since stopping my steady dosage of 100mg oral prog nightly, and going back on/off it, since January (for sports).

I think my new regimen will be: 1mg MB daily (split into 500mcg+500mcg dosages, OR taken all at once) + 12mg oral prog consumed in veggie capsule.

+ @Joeyd Thoughts?

Apparently it's not safe to take methylene blue with foods that have an effect on serotonin? I eat an avocado everyday so I might have to pass on the MB..

edit: I think I'm just gonna give it a shot anyways lol

 

[Progesterone]

Apparently it's not safe to take methylene blue with foods that have an effect on serotonin? I eat an avocado everyday so I might have to pass on the MB..

MAO inhibition only becomes pronounced at 164nM, which is around 2mg.

Top 8 Surprising Health Benefits of Methylene Blue - Selfhacked

The slowing skin aging stuff is very interesting, forgot about all that.

"MB has wildly different effects depending on the dose. In the milligram doses, it shows some MAO-I properties and can kill certain infections.

In the microgram doses, however, it acts via hormetic mechanisms and likely won’t kill an infection or have MAO-I properties."

Health Natura MB is 100mcg per drop, FYI.