Constatine
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- Joined
- Sep 28, 2016
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- 1,781
Have you read all the forums on memantine (which should have similar effects to diamant)? It is well known that such drugs have initial dissociative and negative effects on the mood (especially when overdosed) and that the positive effect on mood is very long term. It typically takes 2 weeks of a small dose to adjust and get benefits (a small dose being 5 mg or less). So if your getting negative effects just lower your dose and wait.Update:
Now that I'm out of the "worst three days" of the month, when high cortisol is very undesirable, I'm noticing some not beneficial effects that I think are due to the adamantane. I've had sleep disturbances for the past couple nights, and this morning woke up at 4a and couldn't get back to sleep. Hearkens back to adrenal fatigue days.
My mood also is not so great. It seemed a bit more volatile than usual during the worst three days, when I was taking the higher dose, but volatility is not unexpected during that time so I couldn't necessarily ascribe that to adamantane. Typically, though, I'm feeling better and much more stable by now. But instead I'm feeling kind of depressed and unmotivated. Little despondent and flat. Not anxious or antsy or stressed, just kind of low-level and almost resignedly unhappy.
Historically I've had a checkered history with things that raise dopamine...initial good reaction then not so much. When younger I enjoyed the mood-boosting effects of drugs like LSD and cocaine but often got depressed after coming down. It's been a loooooong time but it seems like what's happening now is similar to that old feeling.
I didn't really notice any mood boosting effects when taking a higher amount of adamantane...the good effects for me seemed to be more physical and related to cortisol suppression. Which in the context of the worst three days was actually pretty huge. But now it's not.
I'm also getting some minor chronic headaches for the past couple days, which is very unusual. I've had one since I woke up earlier. Headaches aren't even on the list of symptoms I'd compile if someone asked me what I want to fix about my health. Except for today, o'course.
I reduced dose after the worst three days because I've had adrenal fatigue for a long time and am suspicious of what it might mean that this substance "clears" through the adrenal glands. In the past I have tested chronically low cortisol (like, flatlined throughout the day), although for the last few years judging by mood and energy that hasn't been a problem. I'm afraid it could be again, though, if I don't treat my adrenals well.
I think this question was asked upthread but I'll ask again: does anyone know what it might mean that this "clears" through the adrenals?
Not much out there on the side effects of adamantane itself, but Drugs.com says to use the derivative amantadine cautiously with anticholinergics (for me, coffee has a very strong anti-cholinergic effect) as it may intensify anti-cholinergic effects. Other anticholinergics like huperzine combined with coffee have treated me poorly in the past. I'm not drinking much coffee but it's the only way I can take gelatin without gagging, plus I love the taste, so I'd rather keep up with my bitty cup of coffee than worry about possible interaction with admantane.
I was interested in adamantane more for the potential cell stabilizing effects and what that might mean for mood stability but this doesn't seem to be panning out as a daily supp for me. I'm afraid to experiment more aggressively with this because we don't really know anything about its effects on the adrenal glands and I can't afford any big destabilizations to recover from at this point in time.
I may circle back around later or even try this as a prn strategy for stress or the "worst three days", but between what I"m experiencing now and what I read about the sides of the derivative adamantine, no daily or any kind of regular use for me at this time. If that changes I'll update again.