Do you think this plays out in practice if, say, one puts vK in DMSO on the scrote and vE on the face? They'd be far apart on the body and the DMSO solution absorbs more quickly.
Yes, it probably does matter regardless of the body area where they are applied. They should not be in the blood together above a certain concentration. Liver contains both vitamin E and vitamin K but the doses are low compared to supplementation and there is very little interactions. Same reason why EstroBan has "only" 1.5mg vitamin K2 per dose.