Scalp Progesterone For Hair Loss Experiment

[johnwester130]

No greasy feeling. Nothing comparable to vitamin e creams or oils.

DHEA may also upregulate androgens in scalp too, no?

It will block cortisol though. DHEA should be pro hair.

Testosterone makes hair stronger, I remember peat saying

 

[Mossy]

CortiNon - Liquid Progesterone/DHEA Mix

Thank you.

 

[johnwester130]

No greasy feeling. Nothing comparable to vitamin e creams or oils.

DHEA may also upregulate androgens in scalp too, no?

I ordered the product and transferred it to a bottle, the spray was too difficult.

It's a good product. Too greasy for the scalp though, the cream is better.

But on the arms and legs the product is good

 

[Progesterone]

I ordered the product and transferred it to a bottle, the spray was too difficult.

It's a good product. Too greasy for the scalp though, the cream is better.

But on the arms and legs the product is good

You're talking about Ona's spray on prog right?

I am using it orally now, in veggie capsule.

100mg per night.

It has no vit e.. only coconut oil, so it will pass thru the liver.

 

[johnwester130]

You're talking about Ona's spray on prog right?

I am using it orally now, in veggie capsule.

100mg per night.

It has no vit e.. only coconut oil, so it will pass thru the liver.

orally, you want the one with vitamin E.

topically, the cream would be better

"
According to a consultant for a major medical
journal, the idea "...of dissolving progesterone, a fat soluble
steroid hormone, in vitamin E which is then incorporated
into chylomicrons absorbed via the lymphatics, and thus
avoids the liver on the so called first pass is so simple it
is amazing that the pharmaceutical companies have not
jumped on it.""

this won't happen with MCT oil

 

[Progesterone]

orally, you want the one with vitamin E.

topically, the cream would be better

"
According to a consultant for a major medical
journal, the idea "...of dissolving progesterone, a fat soluble
steroid hormone, in vitamin E which is then incorporated
into chylomicrons absorbed via the lymphatics, and thus
avoids the liver on the so called first pass is so simple it
is amazing that the pharmaceutical companies have not
jumped on it.""

this won't happen with MCT oil

The whole point of using orally, is to pass thru the liver, not bypass it. Vit E in this case would not be recommended.

Topically, Vit e makes sense as it will absorb better.

 

[johnwester130]

The whole point of using orally, is to pass thru the liver, not bypass it. Vit E in this case would not be recommended.

Topically, Vit e makes sense as it will absorb better.

"
In the powder form, direct and intimate contact with
a mucous membrane allows lipid phase to lipid phase
transfer of progesterone molecules. Instead of by-passing
the liver, much of the progesterone is picked up in the portal
circulation, where a major part of it is glucuronidated, and
made water soluble for prompt excretion. Since this
glucuronide form cross-reacts to some extent with ordinary
progesterone in the assay process, and since 50% of the
ordinary free progesterone is carried inside the red blood
cells,(10) and 50% is associated with proteins in the plasma,
while the glucuronide hardly enters the red blood cells at all,
it is better to judge by clinical efficacy when comparing
different oral forms. My comparisons show several times
higher potency in the tocopherol composition than in
powder form."

"
When fats are eaten, they are almost 1 00% absorbed
by the small intestine. They break up in the intestine into
microscopic droplets, called chylomicrons, and reach the
general circulation in that form. If progesterone is perfectly
dissolved in oil, it is absorbed in that way, and is not
immediately exposed to enzymes in the wall of the intestine
or in the liver. People often speak of "avoiding the liver on
the first pass," but in fact chylomicrons pass through the
liver many times before they are destroyed; after an hour,
10% of the chylomicrons are still circulating."

 

[Progesterone]

"
In the powder form, direct and intimate contact with
a mucous membrane allows lipid phase to lipid phase
transfer of progesterone molecules. Instead of by-passing
the liver, much of the progesterone is picked up in the portal
circulation, where a major part of it is glucuronidated, and
made water soluble for prompt excretion. Since this
glucuronide form cross-reacts to some extent with ordinary
progesterone in the assay process, and since 50% of the
ordinary free progesterone is carried inside the red blood
cells,(10) and 50% is associated with proteins in the plasma,
while the glucuronide hardly enters the red blood cells at all,
it is better to judge by clinical efficacy when comparing
different oral forms. My comparisons show several times
higher potency in the tocopherol composition than in
powder form."

"
When fats are eaten, they are almost 1 00% absorbed
by the small intestine. They break up in the intestine into
microscopic droplets, called chylomicrons, and reach the
general circulation in that form. If progesterone is perfectly
dissolved in oil, it is absorbed in that way, and is not
immediately exposed to enzymes in the wall of the intestine
or in the liver. People often speak of "avoiding the liver on
the first pass," but in fact chylomicrons pass through the
liver many times before they are destroyed; after an hour,
10% of the chylomicrons are still circulating."

Okay so you're saying it doesn't technically get dissolved in the liver then?

 

[johnwester130]

Okay so you're saying it doesn't technically get dissolved in the liver then?

honestly, I am not sure.

Topically, Cortinon looks good. The DHEA helps too

 

[johnwester130]

Okay so you're saying it doesn't technically get dissolved in the liver then?

this explains it

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.568.2848&rep=rep1&type=pdf

 

[Progesterone]

this explains it

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.568.2848&rep=rep1&type=pdf

nice article! ty

 

[Progesterone]

Guys... watch this!

 

[Progesterone]

Promotion of hair growth by Rosmarinus officinalis leaf extract. - PubMed - NCBI

Abstract
Topical administration of Rosmarinus officinalis leaf extract (RO-ext, 2 mg/day/mouse) improved hair regrowth in C57BL/6NCrSlc mice that experienced hair regrowth interruption induced by testosterone treatment. In addition, RO-ext promoted hair growth in C3H/He mice that had their dorsal areas shaved. To investigate the antiandrogenic activity mechanism of RO-ext, we focused on inhibition of testosterone 5α-reductase, which is well recognized as one of the most effective strategies for the treatment of androgenic alopecia. RO-ext showed inhibitory activity of 82.4% and 94.6% at 200 and 500 µg/mL, respectively. As an active constituent of 5α-reductase inhibition, 12-methoxycarnosic acid was identified with activity-guided fractionation. In addition, the extract of R. officinalis and 12-methoxycarnosic acid inhibited androgen-dependent proliferation of LNCaP cells as 64.5% and 66.7% at 5 µg/mL and 5 μM, respectively. These results suggest that they inhibit the binding of dihydrotestosterone to androgen receptors. Consequently, RO-ext is a promising crude drug for hair growth.

Copyright © 2012 John Wiley & Sons, Ltd.

 

[Progesterone]

Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. - PubMed - NCBI

Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial.
Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A.
Abstract
Rosmarinus officinalis L. is a medicinal plant with diverse activities including enhancement microcapillary perfusion. The present study aimed to investigate the clinical efficacy of rosemary oil in the treatment of androgenetic alopecia (AGA) and compare its effects with minoxidil 2%. Patients with AGA were randomly assigned to rosemary oil (n = 50) or minoxidil 2% (n = 50) for a period of 6 months. After a baseline visit, patients returned to the clinic for efficacy and safety evaluations every 3 months. A standardized professional microphotographic assessment of each volunteer was taken at the initial interview and after 3 and 6 months of the trial. No significant change was observed in the mean hair count at the 3-month endpoint, neither in the rosemary nor in the minoxidil group (P > .05). In contrast, both groups experienced a significant increase in hair count at the 6-month endpoint compared with the baseline and 3-month endpoint (P < .05). No significant difference was found between the study groups regarding hair count either at month 3 or month 6 (> .05). The frequencies of dry hair, greasy hair, and dandruff were not found to be significantly different from baseline at either month 3 or month 6 trial in the groups (P > .05). The frequency of scalp itching at the 3- and 6-month trial points was significantly higher compared with baseline in both groups (P < .05). Scalp itching, however, was more frequent in the minoxidil group at both assessed endpoints (P < .05). The findings of the present trial provided evidence with respect to the efficacy of rosemary oil in the treatment of AGA.

 

[Progesterone]

Peppermint Oil Promotes Hair Growth without Toxic Signs

Peppermint Oil Promotes Hair Growth without Toxic Signs

In conclusion, our experimental data suggest that 3% PEO facilitates hair growth by promoting the conservation of vascularization of hair dermal papilla, which may contribute to the induction of early anagen stage. In addition, PEO effectively stimulated hair growth in an animal model via several mechanisms and thus could be used as a therapeutic or preventive alternative medicine for hair loss in humans.

 

[Progesterone]

This is unreal.

ZINC is so important.

Statistically lower serum zinc concentrations in a study of 312 patients with AA, MPHL, FPHL, or TE compared to 30 healthy controls

Analysis of serum zinc and copper concentrations in hair loss. - PubMed - NCBI

CONCLUSION:
The data led to the hypothesis of zinc metabolism disturbances playing a key role in hair loss, especially AA and TE, whereas the effect of copper on hair growth and shedding cycles still needs more study.

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This is scary:

Vitamin E
Tocotrienols and tocopherols are members of the vitamin E family and are potent antioxidants. Deficiency results in hemolytic anemias, neurologic findings, and skin dryness. Vitamin E deficiency is rare, but may occur with fat malabsorption disorders.

Minimal information in the literature exists regarding benefits of vitamin E supplementation on hair loss. One study of 21 volunteers who received tocotrienol supplementation (100 mg of mixed tocotrienols daily) showed significant increase in hair number as compared to a placebo group [57].

However, excess supplementation may result in hypervitaminosis E, which can increase the risk of bleeding and decrease thyroid hormone production. Additionally, there is some evidence for an adverse effect on hair growth, as seen in volunteers taking 600 IU per day for 28 days, a dosage around 30 times the daily recommended intake [8]. This group had significant decreases in thyroid hormone levels [8].

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[Broken man]

Any thoughts on injecting BCP-157 or TB-500 directly into scalp?

Or rather any reason I should NOT try it?

Yeah, I read about tb 500 and hairloss but cant find much experience by others.

 

[Inaut]

Good posts @Progesterone

 

[Nigluva]

Yeah, I read about tb 500 and hairloss but cant find much experience by others.

I do not think you should because you cannot really be certain grey market peptides are that safe. There is a toxic solvent TFA used in peptide synthesis for media or research grade, they can synthesize human grade without it, but I have queried peptide suppliers and gotten pricing from synthesis labs and done some digging and it doesn't seem likely. The pricing just doesn't add up that they are doing human grade synths.

 

[Nigluva]

The consensus seems to be that Swiss Temples didn't get the results people were expecting, because he disappeared into the underground and never posted update photos even on the private forum. So either that or he's being a little b**** boy, but then who has replicated his results? No one that I'm aware of.

He posts on raw carnivore subreddit and he said that he is satisfied with his regrowth so he stopped. I remember the hype tho.