LeeLemonoil
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- Sep 24, 2016
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Although I lack the understanding you guys have, I was digging around tonight trying to find things that induce autophagy because I feel like it's the keystone and also possibly the way estrogen works.
I think I found something you need to read
This is indeed required and essentila reading for anyboy interested in truly understanding hairloss.
It's also a strong indication and lends credibility to what Pnbecker found out.
With regards to Estrogen/Fina, this would indicate that neither migth be necessary for achieveing regrowth - or that guys like @ChemHead need to determine if Finasteride use migt alter steroids or bring about steroids and signaling that for a short term increase autophagy in such a substantial way as laid out in th epublication. This is, imo, the most plausible explainatin for hat Chemhead experienced.
In combination with things that show limited regrowth effects and additional topicas and systemic maintenace with polyphenols or aspirin and the like, this is the best bet to achieve regrowth. Things like regular Dermarolling would hasten and improve the process.
Also, you should find ut if Ketaconazole, in addition to blocking nlrp3, would also influence autophagy, like oligomycin used here
This gives other hints, Estrogen won't work I think. It has sotrt of regulatory, homeostatic effects on Autophgay. Maybe high dose Fina shortly provoked very strong autophagy-onset but get reigned in by Estrogen shortly after.
How does estrogen work on autophagy? - PubMed
Macroautophagy/autophagy is vital for intracellular quality control and homeostasis. Therefore, careful regulation of autophagy is very important. In the past 10 years, a number of studies have reported that estrogenic effectors affect autophagy. However, some results, especially those regarding...
pubmed.ncbi.nlm.nih.gov
More to find that Est can inhibit Autophagy.
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