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I Think I’ve Finally Figured Out How To Use Niacinamide

Discussion in 'B3/Niacinamide' started by Inaut, May 27, 2019.

  1. Inaut

    Inaut Member

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    so I’ve used niacinamide on and off for the last couple of years. Typically in doses of 500mg at a time (due to the capsules coming in that amount), it never really agreed with me. I’d take it but wouldn’t see any benefit.....

    After listening to Chris Masterjohn discuss niacin/amide/ nicotinimide riboside in one of his YouTube videos, i clued in to the fact that the dosage I was taking was counter productive. I also recalled Masterjohn saying that only about 40mg per hour can be absorbed into the blood stream so I figured why not aim for smaller doses, more frequently throughout the day.


    For the last two or so weeks, I’ve been opening up the capsule and adding a bit to water throughout the day. In total, the 500mg capsule might last me two days but the energy and feeling I get from it is quite impressive. Shortly after ingestion, I notice my body temperature rises substantially almost to the point of a light sweating for about 5 minutes. After the water, I follow up with some orange juice.

    Other thing to note is my libido is off the charts. Like I’m in my teens again.... I’m taking other things as well so I won’t attribute it solely to niacinamide (limonene, caffeine, and mag malate to name a couple) but am really happy with the direction I am going in. Energy is best it’s been in a long time.

    For those not getting good results from niacinamide, maybe try reducing the dosage but using it more frequently. Might be helpful.

    Just thought I’d share
     
  2. shine

    shine Member

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    Sounds like home-made slow release. Could be damaging your liver over time. I followed a similar dosing pattern years ago and felt amazing effects initially but ended up with an inflamed liver with enzymes in the 300s.
     
  3. lampofred

    lampofred Member

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    Were you taking slow release niacin or ordinary niacinamide dosed in a slow release manner?
     
  4. OP
    Inaut

    Inaut Member

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    Niacinamide

    Apologies. @lampofred i just realized your question was for @shine.
     
  5. Vinny

    Vinny Member

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    Hi man,
    Is there any evidence, bsids ur personal experience, that niacinamide damages the liver?
    If yes, then why people take it and why is so valued in this forum?
     
  6. shine

    shine Member

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    I started out with slow release niacin and then took niacinamide 3x daily for many months.
    That was years ago. I was generally living a very unhealthy life with lots of PUFA in my diet and the B3 really helped in the beginning, but after a while everything went downhill and I became more and more fatigued.
    I am not saying regular high doses of niacin/niacinamide were the sole cause for that and I am not advocating against it, I am just saying be cautious.
     
  7. olive

    olive Member

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    You shouldn’t really be taking niacinamide after sun down, it messes with the circadian clock via SIRT1.

    But you are on the right track with dose. 500mg is far too large. ~50mg upon waking with a large carb only meal (preferably including fruits) is a great way to start the day.
     
  8. OP
    Inaut

    Inaut Member

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    Thanks for the comment @olive . Will definitely keep this in mind :)
     
  9. FredSonoma

    FredSonoma Member

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    Do you have digestive issues? Did it help?
     
  10. OP
    Inaut

    Inaut Member

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    I did/do have slight digestive issues
     
  11. rawmeat

    rawmeat Member

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    This is similar to how Ray Peat recommends taking it.

     
  12. OP
    Inaut

    Inaut Member

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    Bump bump bump.

    I probably did 50mg, three times today and it’s profound. Cant usually correlate effects of supplements but for this I can.

    Ray for the win!!!!
     
  13. rawmeat

    rawmeat Member

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    Ray is half man half God.
     
  14. Kyle Bigman

    Kyle Bigman Member

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    isn't inhibition of sirt1 what accelerates aging? why would one want to take niacinamide if that's the case
     
  15. aquaman

    aquaman Member

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    I find this good - high carb, low fat breakfasts with an FFA inhibitor works great
     
  16. Soren

    Soren Member

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    I'm surprised that the niacinamide caused your inflamed liver especially when there is evidence that shows niacinamide can treat and even cure Liver cancer. I think it is more likey down to the other factors you mentioned, poor diet, high PUFA etc.

    Niacinamide Can Cure Liver (and Maybe Pancreatic) Cancer
    The human equivalent dose was 5.5mg per kg of body weight so someone weight 80kg would be taking 4.4grams a day!



     
  17. Soren

    Soren Member

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    Someone had the same concern about liver enzymes and Niacinamide in another thread,

    Haidut response;

    So elevated enzymes are not even necessarily a bad thing they could be a sign of the liver working the way it is supposed to.
     
  18. shine

    shine Member

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    My liver hurt really bad from lightly touching it.
    It was more like 6x upper limit.
    I was ingesting lots of canola oil at that time though.
     
  19. Alex Jaramillo

    Alex Jaramillo Member

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    I tried this today. Just dabbed some on to the tongue. It’s kind of bitter tasting
     
  20. Soren

    Soren Member

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    6x! damn that is pretty bad. Yea canola oil definitely wouldn't help. My policy on supplements is always to exercise caution and take it slow. I've definitely overdone it myself in the past.
     
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