Cyproheptadine - Liquid Serotonin Antagonist For Lab/R&D

[DennisX]

I usually take4 drops=2mg a night before sleep. 3xaweek to antagonize 5HTb2 serotonin receptor.

 

[redsun]

anyone get extreme drowsniess after this? one drop in the middle of the day and i take a 2 hour nap. wat mean?

Its the histamine antagonism putting you to sleep. You should not take antihistamines in the middle of the day if you have to take them.

 

[Sulcuscentralis]

anyone get extreme drowsniess after this? one drop in the middle of the day and i take a 2 hour nap. wat mean?

Yes it’s normal- that’s why I only take it before bed.

 

[eat my peat]

been taking 2mg before bed and sleep like a baby. only annoying thing is i wake up still super tired to go to work.

then ... coffee

 

[Kvothe]

anyone get extreme drowsniess after this? one drop in the middle of the day and i take a 2 hour nap. wat mean?

That's probably an effect of sudden histamine antagonism. I slept 18 hours the first time I took cypro (2mcg).

 

[eat my peat]

That's probably an effect of sudden histamine antagonism. I slept 18 hours the first time I took cypro (2mcg).

Amazing - thoughts on taking a higher dosage of 4mg ?

 

[I'm.No.One]

So I've been binge reading about cypro & think it would be beneficial to many rats I keep in my home including the rat that's miraculously able to type this out.

However, this rat has had severe chronic stress for the last, sh!t almost 5 years. Rat now has flipped cortisol. Like almost none it it's body during the day then BAM sky high levels at night.

With cypros ability to lower cortisol would this actually be dangerous in this rats case?

Would rat be subject to an adrenaline crisis during the daytime because cypro lowered their cortisol even further?

Ideas? Thoughts?

@haidut

 

[Sulcuscentralis]

So I've been binge reading about cypro & think it would be beneficial to many rats I keep in my home including the rat that's miraculously able to type this out.

However, this rat has had severe chronic stress for the last, sh!t almost 5 years. Rat now has flipped cortisol. Like almost none it it's body during the day then BAM sky high levels at night.

With cypros ability to lower cortisol would this actually be dangerous in this rats case?

Would rat be subject to an adrenaline crisis during the daytime because cypro lowered their cortisol even further?

Ideas? Thoughts?

@haiduty

My rat was in a similar situation Use it late in the afternoon and skip it in the morning. It might help.

 

[I'm.No.One]

My rat was in a similar situation Use it late in the afternoon and skip it in the morning. It might help.

Thank you & that makes sense as late afternoon is when the rats levels begin to climb.

 

[Basonh]

Yes, 1 drop would be 0.5mg. Topical application may increase half life even beyond the 8 hours or oral route so I'd watch rat symptoms closely.

Where would the best site topically on my rat be ?

 

[I'm.No.One]

Where would the best site topically on my rat be ?

My rat is having good results on the inner elbow, like where blood would be drawn from.

 

[xeliex]

I had been using this cypro topically on my angel for years. My angel has had mild but generally pleasant effects from it.

Yesterday, I gave my angel two drops on the tongue instead of topically. My angel slept for 12 hours and high serotonin symptoms 90% resolved, wow and morning wood!

Overnight large improvement in whole body twitching, joint pain, irritated gutt, outlook on life, sleep quality, etc...

Angels recommend cyproheptadine.

 

[Waynish]

Does anyone notice a similarity between cypro and camphor? @haidut Any idea how cypro was discovered and first synthesized?

 

[johnwester130]

Does anyone notice a similarity between cypro and camphor? @haidut Any idea how cypro was discovered and first synthesized?

I always thought cypro felt like menthol -

 

[Waynish]

I always thought cypro felt like menthol -

Me too, both feel kind of similar

 

[Cloudhands]

anyone try it topically for localized histamine related skin issues?

 

[Stan]

Haidut's Cyproheptadine Review 2019 (Ray Peat Forum Cyproheptadine Review 2019) [Cyproheptadine Reviews 2019]

This product was purchased on Idea Labs DC ( Lab ). ---HERE--- It is mentioned on Ray Peat Forum (with all research listed) as...

area1255.blogspot.com

So how much did you pay this shill to advertise your product @haidut ? Most cringiest ***t I've read.

Now here's some real experiences from real people claiming the opposite - cycproheptadine ruins their libido.

Sexual Experiences With Cyproheptadine?

just got some cyproheptadine to help with eczema and sleep. I've read that it lowers Testosterone etc.. is this not something to be worried about if only taking 0.5 - 2mg dose daily? The lowering of testosterone would only be temporary while taking cyproheptadine right? Wouldn't permanently...

raypeatforum.com

Did Cyproheptadine increase you libido or lowered your libido?

Or you had a high libido and Cyproheptadine had no discernible effect on your libido? Did Cyproheptadine increase your libido or lower your libido?

raypeatforum.com

 

[tommyg130]

Due to popular demand, we have released the well-known chemical cyproheptadine as a product for R&D use only. I don't think cyproheptadine needs any introduction here, so I have simply provided the Wikipedia links and some relevant links from the forum.
Cyproheptadine - Wikipedia

Please note that similar to the products sold by companies like BluePeptides, this product if for lab/research use only. The product can be ordered from the link below:
IdeaLabs Online Store - Worldwide Ordering And Delivery - Laboratory Research Chemicals

*******************************************************************************
Cyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It is one of the oldest synthetic antihistamine and antiserotonin drugs, with use spanning more than 5 decades. As such, cyproheptadine is second to none in terms of known properties, risks, and dose-response effects.

Drops per container: about 360
Each drop contains the following ingredients:

Cyproheptadine (Hcl), USP: 0.5 mg

Other ingredients: add product to shopping cart to see info
*******************************************************************************

References:
Blocking Serotonin Extends Lifespan By 40%, Triples Youthspan
Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It
Serotonin Causes Autism; Blocking It May Treat Autism
Cyproheptadine, LSD-based Drugs Can Regenerate Damaged Liver
Benadryl and cyproheptadine protect from endotoxin poisoning
Cyproheptadine - A Wonder Drug?
Cyproheptadine prevents exercise-induced leaky brain
Cyproheptadine Is Anti-inflammatory
How cyproheptadine lowers stress
Cyproheptadine May Treat Ebola Infection
Cyproheptadine as a fertility drug in old males
Cyproheptadine As A Powerful Antidepressant
Cyproheptadine Prevents / Reverses Soft Tissue Calcification
Cyproheptadine Lowers Cortisol, Endorphins, HGH, Aldosterone
Cyproheptadine Effective For Functional GI Disorders

Is this best applied topically or orally ? Thank you ! I would think topically bc it has the SFA esters ?

 

[haidut]

Haidut's Cyproheptadine Review 2019 (Ray Peat Forum Cyproheptadine Review 2019) [Cyproheptadine Reviews 2019]

This product was purchased on Idea Labs DC ( Lab ). ---HERE--- It is mentioned on Ray Peat Forum (with all research listed) as...

area1255.blogspot.com

So how much did you pay this shill to advertise your product @haidut ? Most cringiest ***t I've read.

Now here's some real experiences from real people claiming the opposite - cycproheptadine ruins their libido.

Sexual Experiences With Cyproheptadine?

just got some cyproheptadine to help with eczema and sleep. I've read that it lowers Testosterone etc.. is this not something to be worried about if only taking 0.5 - 2mg dose daily? The lowering of testosterone would only be temporary while taking cyproheptadine right? Wouldn't permanently...

raypeatforum.com

Did Cyproheptadine increase you libido or lowered your libido?

Or you had a high libido and Cyproheptadine had no discernible effect on your libido? Did Cyproheptadine increase your libido or lower your libido?

raypeatforum.com

I paid him exactly $0. In fact, there is NO financial relationship between that blog and us.
You'd do yourself a favor if you go see a doctor ASAP. Your mental state strongly suggests you are a threat to yourself and others.

 

[celeste]

@haidut Hello, I recently received cyproheptadine and I’m wondering if the label information is correct or has changed. It says 1 drop contains 1 mg cypro, but I’ve seen users in many threads say 1 drop equals 0.5 mg… I’m worried I’m dosing it wrong. Thanks!