histamine

Yet another blow to the status of the so-called "happiness hormone". While histamine, acetylcholine, and estrogen have long been known as key drivers of asthma the link between the mast cells and the nervous system's production of the vasoconstrictor acetylcholine has remained unknown. The study...

I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones...

A few months ago, I did a post about a study which made the bold claim that estrogen instead of HPV is the actual cause of the (often deadly) cervical cancer. According to that study, HPV infection is at best permissive and at worst simply an (largely innocent) bystander. A statement like this...

Hi guys, I’d like to do a trial with iodine, since I’ve seen that it could help with clearing histamine and some symptoms that I believe are related to hypo, i.e. brain fog, dry skin and cold hands. Is supplementing with Kelp a good idea? It has 150mcg iodine. With that dosage is it necessary...

I wanted to make a single thread for myself to post histamine related studies. As Peat himself is not a fan of histamine, lumping it together with things like cortisol and serotonin, I want to stick to one thread for all studies instead of posting them each as their own seperate thread in order...

About 2 years ago I did a post discussing the hypothesis that melanoma is an endocrine tumor, similar to breast cancer - i.e. driven by estrogen. In fact, if one has the time to dig into the published literature on all known malignancies, it quickly becomes apparent that virtually all cancers...

Self explanatory title. But basically describes relationships between thyroid hormones (T4 and T3), thyroid metabolites, and mast cell function as well as histamine. Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue "Interestingly, brain mast cells contain not...

I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation...

This is perhaps the most stunning article to date I have seen in mainstream media (MSM). For more than 100 years the story has always been that cancer is a genetic disease due to mutations that turn cells into rampant killing machines. Now, one of the bastions of MSM - the mighty "Atlantic" -...

Was surprised when saw a study showing statins have positive effects on bones, did a bit of searching and it turned out that it has some positive action,generally, through inhibiting rho kinase, which also is protective against heart disease. Im not promoting statin use at all(for obvious...

Most of the forum members probably know that the incidence of "autoimmune" conditions is much higher in women then in men. This fact gets consistently ignored by doctors working in the field as a mere fluke, or due to "unknown hormonal interactions" which are nonetheless deemed not causative of...

Carnosine attenuates mast cell degranulation and histamine release induced by oxygen-glucose deprivation. - PubMed - NCBI Carnosine (beta-alanyl-histidine) is a naturally occurring dipeptide that has been characterized as a putative hydrophilic antioxidant. The protective function of carnosine...

Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. - PubMed - NCBI Impact of oral vitamin C on histamine levels and seasickness. - PubMed - NCBI

I probably will edit this post and update it. Magnesium and tnf alpha interaction Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. - PubMed - NCBI Adequate zinc intake is necessary for protection against tnf alpha and pufa Zinc nutrition and...

Anti-histamine Therapy and Bone Mineral Density: Analysis in a Population-Based U.S. Sample Background Histamine may play an important role in bone turnover. The data regarding histamine receptor antagonists (H1RA, H2RA) and bone mineral density in humans are sparse. We examined bone mineral...

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model Abstract Background Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their...

I am posting this study for those people who need an alternative to thyroid hormone treatment. This is a human study, so it is even more relevant for people with Hashimoto's. Given the main effects of ketotifen as a histamine and leukotriene antagonist, as well as some serotonin antagonism it...

Meet your new beauty ingredient - ketotifen. UV light exposure is one of the main triggers of visible signs of skin aging and contributes to lipofuscin formation as well. It looks like ketotifen may be able to prevent that damage and given its leukotriene and histamine antagonism it may be a...

Many people on the forum have reported struggling with poor digestion, and some have experienced relief by taking digestive enzymes. Peat and many other researchers have written about the connection between poor digestion and virtually all chronic conditions. The pancreas can get damaged by a...

Effect of magnesium chloride on rabbit bronchial smooth muscle. - PubMed - NCBI Ann Emerg Med. 1990 Oct;19(10):1107-12. Effect of magnesium chloride on rabbit bronchial smooth muscle. Spivey WH1, Skobeloff EM, Levin RM. "Magnesium chloride produced dose-dependent relaxation of bronchial...