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  1. haidut

    Fasting decreases androgens, increases aldosterone (and possibly cortisol/estrogens) in women

    I often get criticized that I rely too much on animal studies, so here is a human one that should give the proponents of caloric restriction / fasting a pause. Even a short fast (24-48 hours) resulted in decreased androgen synthesis in women, while increasing aldosterone. In general, fasting...
  2. haidut

    Exercise causes (and worsens) arterial calcification

    A great new study sent to me by one of my readers. It will more than likely cause a lot of controversy, despite its findings having a very simple explanation. Namely, chronic exercise increases baseline cortisol and over time, cortisol (acting through the aldosterone/mineralocorticoid receptor)...
  3. haidut

    Vitamin D, reducing fat oxidation may treat lung fibrosis, COVID-19

    Pulmonary fibrosis, regardless of etiology, is considered invariably a progressive and fatal disease. Despite this official story, behind the scenes several pharma companies are running clinical trials with several anti-fibrotic agents and the results so-far demonstrate that the condition is...
  4. haidut

    Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens

    A very interesting study that highlights yet again the connection between chronic stress and ill systemic health, especially cardiovascular disease (CVD). The study demonstrates that people who had experienced a heart attack have dramatically higher higher cortisol and adrenaline/noradrenaline...
  5. E

    DHT Decreases Adrenal Androgens

    Although it's not directly DHT, study says Proviron (Mesterolone) decreases adrenal androgen synthesis which is a marker of poor gonadal function. That means it increases gonadal function. It also increases aldosterone? Profiling of Anabolic Androgenic Steroids and Selective Androgen Receptor...
  6. md_a


    I think excess cortisol-aldosterone- mineralocorticoid activation trough angiotensin system are main players in balding by cytokine activation and progressing to fibrosis. Focusing on TGF-β₁, which shuts off the anagen phase of the hair cycle, and 11β-HSD₁ expression should fix to the problem...
  7. GorillaHead

    Anyway To Lower Aldosterone A Little Bit Without Using Anti Androgens

    I have naturally a higher level of aldosterone than most. Skinny body. Very weak appetite. Borderline high fating blood glucose. Borderline high blood pressure. I read salt actually increases aldosterone in many studies. so I am kinda lost at my options
  8. Adrenaline

    Interesting Facts About Cyproterone (Hair Loss)

    Cyproterone Acetate is an anti-androgen drug used for transitioning, hair loss, acne, hirsutism and so-called androgenic disorders. But when I search PubMed I found interesting mechanisms about this drug. * First of all it strongly decreases cortisol and aldosterone and increases DHEA levels...
  9. Tristan Loscha

    Anti-Peat High-Salt Augments Aldosterone Toxicity Despite Lowered Plasma-Readings

    High-Salt Augments Aldosterone Toxicity Despite Lowered Plasma-Readings. Blood-LVL-Aldosterone gets lowered by sodium,but apparently sensitivity rises,augmenting damage.Sodium is truly almost a micronutrient,with intakes as low as 500mg-1500mg,in indigenous tribes,lower than magnesium,lower...
  10. haidut

    Cortisol And Aldosterone Cause Vascular Calcification

    In one of his newsletter circa 2015, Ray wrote about the role of aldosterone in heart failure, heart attacks, shock, and edema. He conjectured that aldosterone antagonists would one day be recognized as therapeutic for these conditions. Almost all types of heart disease start with vascular...
  11. raypeatclips

    Magnesium Sulfate And Chloride Inhibits Aldosterone

    Magnesium ion: a possible physiological regulator of aldosterone production. - PubMed - NCBI Life Sci. 1989;44(20):1483-9. Magnesium ion: a possible physiological regulator of aldosterone production. Atarashi K1, Matsuoka H, Takagi M, Sugimoto T. "Both magnesium sulphate (MgSO4) and magnesium...
  12. haidut

    Pregnenolone Is A Potent Aldosterone Antagonist (antimineralocorticoid)

    Ray has written a number of articles on the hypertension, heart and kidney failure, eclampsia, and CVD in which he describes the central role of aldosterone in the pathogenesis of these conditions. Aldosterone antagonists (antimineralocorticoids - e.g. spironolactone, itself a pregnenolone...
  13. haidut

    Cyproheptadine - Liquid Serotonin Antagonist For Lab/R&D

    Due to popular demand, we have released the well-known chemical cyproheptadine as a product for R&D use only. I don't think cyproheptadine needs any introduction here, so I have simply provided the Wikipedia links and some relevant links from the forum. Cyproheptadine - Wikipedia Please note...
  14. Koveras

    Aldosterone Causes Fat Gain, Sodium May Prevent It

    In confirmation of what @haidut said here Salt Prevents Weight Gain On High Fat Diet These researchers have shown that blocking Aldosterone, in this case with a receptor blocker, prevents fat gain on a high fat diet. The same effect of reducing aldosterone signalling, may be achievable more...
  15. haidut

    Cyproheptadine Lowers Cortisol, Endorphins, HGH, Aldosterone

    Ray's last newsletter focused on endorphins and NO in various pathologies, including cancer. I don't need to mention that cortisol is also something you want to keep low. More importantly, it seems that serotonin is the cause behind Cushing disease and/or elevated cortisol levels (Cushingoid...