Interesting find!
There is one of a small series of articles by DiLuzio, Wooles, Saba, etc. on methyl palmitate and the reticulo-endothelial system that seemed to have ended about 50 years ago.
They seemed to have used methyl palmitate in an IV emulsion made by sonification.
Evaluation of humoral and cellular mechanisms of methyl palmitate induced reticuloendothelial depression. - PubMed - NCBI
This study used 200 mg of methyl palmitate per 100 gm of body weight in rat subjects. That is 2 gm per kg of weight, or over 100 grams intravenously in a human equivalent.
It’s not clear what started this research strand, or how the researchers chose to move on.
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“Blickens and Di Luzio reported that the methyl palmitate depression of RE function was neither related to a saturation of macrophages with the injected lipid nor to the formation of methanol following methyl palmitate hydrolysis. These observations, coupled with the absence of any hepatic macrophage morphological and/or cell number alterations following methyl palmitate administration, has further obscured the mechanism of methyl palmitate depression of the RES.”