fibrosis

  1. haidut

    Aspirin may reverse NAFLD/fibrosis by reducing fat accumulation, inflammation

    Another great win for aspirin, especially considering the prevalence of NAFLD, NASH, fibrosis/cirrhosis and even liver cancer. This post comes mere minutes after the post on a single tablet aspirin (300mg) daily putting a terminal liver cancer in remission. This study below used a low-dose...
    • haidut
    • Thread
    • aspirin cirrhosis fat fibrosis inflammation liver nafld nash
    • Replies: 22
    • Forum: Scientific Studies
  2. haidut

    LipOdd - Liquid Product With Odd-Chain Saturated Fats (SFA)

    More than a decade ago, when I was just beginning my exploration of bioenergetics, one of the first indications that Ray's writings were onto something when it came to SFA vs. PUFA was the fact that while mainstream medicine ruthlessly bashed SFA in general and promoted PUFA, virtually very...
    • haidut
    • Thread
    • aging anemia antibacterial autoimmune cancer cvd depression diabetes fibrosis heptadecanoic inflammation lifespan lipodd metabolism mitochondria neurodegeneration obesity oxphos pentadecanoic sfa
    • Replies: 93
    • Forum: IdeaLabs
  3. haidut

    Serotonin (5-HT) drives diabetes and liver disease, blocking it is therapeutic

    After more than a decade of doing research in bioenergetics, I have come to the conclusion that there is hardly a disease (both acute and chronic) where 5-HT is not involved as a causal factor. Out of all those conditions, the ones with the biggest public health impacts are probably obesity...
    • haidut
    • Thread
    • 5-ht diabetes fibrosis inflammation nafld nash obesity serotonin
    • Replies: 5
    • Forum: Scientific Studies
  4. haidut

    Aspirin may treat (idiopathic) pulmonary fibrosis (PF)

    I mentioned in several of my latest podcast appearances that Pfizer is running clinical trials with a serotonin antagonist to reverse/treat several lethal conditions, for which medicine claims there is no cure. Those conditions include heart fibrosis / heart failure, pulmonary hypertension...
    • haidut
    • Thread
    • aspirin autophagy fibrosis inflammation lungs mtor pulmonary fibrosis scar
    • Replies: 8
    • Forum: Scientific Studies
  5. haidut

    Niacinamide/NAD+ may prevent heart failure

    The rates of cardiovascular disease (CVD) continue to rise and the condition is still the top killer in developed countries, though it is likely that cancer will take the top spot in the next few years and CVD will move back to second place. Heart failure (HF) is one of the common outcomes of...
    • haidut
    • Thread
    • fibrosis heart failure nad niacinamide nicotinamide oxphos
    • Replies: 0
    • Forum: Scientific Studies
  6. haidut

    Serum endotoxin level is a reliable biomarker of liver disease

    It looks like the interest in gut-derived pathogenic substances is steadily increasing in the medical field. After claiming for decades (and still doing so) that liver disease is either genetic in origin or driven mostly by sugar (especially fructose) consumption, now studies like the one below...
    • haidut
    • Thread
    • endotoxin fibrosis inflammation liver lps nafld nash tlr4
    • Replies: 16
    • Forum: Scientific Studies
  7. haidut

    SSRI/serotonin cause heart damage/failure

    The role of serotonin in fibrotic conditions is well-known in research circles but is a taboo topic in medicine. Perhaps the best example of this bipolar (and potentially criminal) attitude is the fact that Pfizer sells billions of dollars worth its SSRI drugs Zoloft and Pristiq, yet at the same...
    • haidut
    • Thread
    • 5-ht fibrosis heart damage heart failure mitral valve serotonin ssri
    • Replies: 9
    • Forum: Scientific Studies
  8. Limon9

    MTOR Activates Warburg Effect From Endotoxin

    As Dr. Peat referred to in his newsletters, it's no surprise that a cell-proliferative enzyme activates aerobic glycolysis. Oxidative energy production is halted so the cells may regress to a primitive growth-state. Inhibiting either mTOR or the glycolytic enzyme it upregulated was sufficient to...
    • Limon9
    • Thread
    • endotoxin fibrosis glycolysis lps mtor pfkfb3 rapamycin warburg effect
    • Replies: 17
    • Forum: Scientific Studies
  9. haidut

    Estrogen causes prostate fibrosis (cancer?), DHT prevents/treats it

    Slowly, but surely, the myth of the "evil" dihydrotestosterone (DHT) and the "beneficial" estrogen, when it comes to prostate health, is going the way of the dodo. In fact, people I know who work in research circles say that the "androgen hypothesis" in prostate cancer is no longer being taken...
  10. haidut

    PUFA metabolite (prostaglandin) promotes lipolysis / fibrosis, causes obesity / diabetes

    Just in case there are still doubts out there about just how detrimental PUFA is to our health, here is a study showing that just one of PUFA's "normal" metabolites (i.e. enzymatically derived, instead of through peroxidation) is sufficient to elevate lipolysis, and that effect alone is enough...
    • haidut
    • Thread
    • aspirin cox diabetes fibrosis lipolysis obesity pge2 prostaglandin pufa
    • Replies: 2
    • Forum: Scientific Studies
  11. haidut

    PUFA damages mitochondria, blocks mitophagy, leads to heart damage

    I can't get access to the full study text, so the comments I have here are based only on the abstract of the study below. However, even just the abstract is sufficient to demonstrate once again the dangers of PUFA. Despite the study not calling PUFA out directly, it does mention lard as the food...
    • haidut
    • Thread
    • debris fibrosis heart inflammation lard mitochondria mitophagy pufa
    • Replies: 2
    • Forum: Scientific Studies
  12. haidut

    Aspirin may treat pancreatitis...and other fibrotic conditions

    While most of medicine's attention is focused on acute pancreatitis (AP) since AP is often deadly, rates of chronic pancreatitis (CP) have been rising over the last 2-3 decades and it is now recognized that CP is a "gateway" condition to either liver or pancreatic cancers. Officially, CP has no...
    • haidut
    • Thread
    • aspirin cancer cox fibrosis inflammation pancreas pancreatitis pufa
    • Replies: 8
    • Forum: Scientific Studies
  13. haidut

    Vitamin D can prevent, and even reverse, the cancerization process

    The study is on ovarian cancer but I don't see why its findings won't apply to all other cancers, as the study itself states, especially the ones forming in the abdominal cavity and involving the peritoneum. he study found that vitamin D can actually restore the "cancer" cells back to normal...
    • haidut
    • Thread
    • cancer cholecalciferol fibrosis inflammation ovarian peritoneum vitamin d vitamin d3
    • Replies: 18
    • Forum: Scientific Studies
  14. haidut

    Aspirin can slow down the progression of emphysema

    Yet another study, adding to the mountain of evidence that if there is such a thing as a "wonder drug" then aspirin comes as close to it as possible. The study findings are great news not only because emphysema is such a widespread disease, but also because it is considered both progressive and...
    • haidut
    • Thread
    • aspirin copd emphysema fibrosis inflammation lung pulmonary
    • Replies: 5
    • Forum: Scientific Studies
  15. A

    Stearic acid attenuates profibrotic signalling in idiopathic pulmonary fibrosis

    Background and objective: Lipid metabolism dysregulation has been implicated in the pathogenesis of IPF; however, the roles of most lipid metabolites in lung fibrosis remain unexplored. Therefore, we aimed to identify changes in lipid metabolites in the lung tissues of IPF patients and determine...
  16. haidut

    Vitamin D, reducing fat oxidation may treat lung fibrosis, COVID-19

    Pulmonary fibrosis, regardless of etiology, is considered invariably a progressive and fatal disease. Despite this official story, behind the scenes several pharma companies are running clinical trials with several anti-fibrotic agents and the results so-far demonstrate that the condition is...
    • haidut
    • Thread
    • aldosterone angiotensin cholecalciferol covid-19 fibrosis lung renin sars-cov-2 vitamin d
    • Replies: 19
    • Forum: Scientific Studies
  17. haidut

    How lipolysis may damage organs such as the heart

    It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...
    • haidut
    • Thread
    • adipocytes debris fibrosis heart lipolysis mitochondria ros
    • Replies: 0
    • Forum: Scientific Studies
  18. haidut

    Upregulated serotonin synthesis may be a biomarker for breast cancer

    Once again, the available evidence contradicts the popular myth promoted by public health agencies that serotonin is the "happiness hormone". One only needs to talk to a person on serotonergic (SSRI) drugs for a few minutes to realize just how "happy" those people are as a result of their...
    • haidut
    • Thread
    • biomarker breast cancer fibrosis melatonin predictive serotonin ssri synthesis
    • Replies: 0
    • Forum: Scientific Studies
  19. haidut

    Vitamin D (topical) safe and effective for removing scars

    A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical/heat burns, radiation, etc. As the study says, the typical treatment is with...
    • haidut
    • Thread
    • cholecalciferol fibrosis keloid scars skin vitamin d vitamin d3
    • Replies: 15
    • Forum: Scientific Studies
  20. Mauritio

    Bromantane reduces liver fibrosis by 60%, kidney fibrosis by 50%

    This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis. I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not...
    • Mauritio
    • Thread
    • bromantane dopamine fibrosis kidney fibrosis ladasten liver fibrosis nafld nash np-160
    • Replies: 18
    • Forum: Scientific Studies
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