fibrosis

Pulmonary fibrosis, regardless of etiology, is considered invariably a progressive and fatal disease. Despite this official story, behind the scenes several pharma companies are running clinical trials with several anti-fibrotic agents and the results so-far demonstrate that the condition is...

It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...

Once again, the available evidence contradicts the popular myth promoted by public health agencies that serotonin is the "happiness hormone". One only needs to talk to a person on serotonergic (SSRI) drugs for a few minutes to realize just how "happy" those people are as a result of their...

A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical/heat burns, radiation, etc. As the study says, the typical treatment is with...

This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis. I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not...

If you contemplate taking finasteride/ dutasteride read this study. Or just ask yourself:" do I potentially want a fibrotic penis ?" Another reason not to take dutasteride or finasteride: they cause fibrosis of the penis and prostate and increase the expression of the estrogen receptor and...

The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...

Anyone ever used Methylene Blue on hairline? I used to dermastamp aggressively and created scar issue unfortunately. Thus I am looking to minimize/reverse some of that damage if at all possible. Would applying Methylene Blue on areas of the scalp where I created scar tissue, be helpful? (wound...

Anger, stress, dysregulation produces wear and tear on the lung How stress influences disease: Study reveals inflammation as the culprit I think we can all piece this together here.

A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This...

I think excess cortisol-aldosterone- mineralocorticoid activation trough angiotensin system are main players in balding by cytokine activation and progressing to fibrosis. Focusing on TGF-β₁, which shuts off the anagen phase of the hair cycle, and 11β-HSD₁ expression should fix to the problem...

Coronavirus ‘like a combination of SARS and AIDS’ Autopsies of the people dead in wuhan shows ”irreversible” lung damage even if the patient recovers. Pulmonary fibrosis is permanent scarring of the lung tissue that can leave the patient chronically out of breath. The paper described an...

Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...

Collagen accumulates with aging and causes fibrosis. Although this study only highlights aged donors, it shows that lidocaine antagonizes the pro-fibrotic effects of IGF-1, TGF Beta-1, collagen proteins and inhibits collagen accumulation. Lidocaine impairs proliferative and biosynthetic...

A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the...

As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...

Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...

Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin "a promising anti-fibrotic strategy for NAFLD". This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the...

The bad news for younger Americans just keep on coming. In addition to lethal cancers, diabetes, stroke, CVD, infertility, etc now we can add yet another "old man" disease to the list of banes inflicting the "young". The "Young" Have Now Become The Old Heart failure is a condition traditionally...

Yet another sad reminder of just how much the health of the average person has declined over the last 20 years. They truly are becoming the "new old". The "Young" Have Now Become The Old If these trends are not reversed or at least slowed down, we may start seeing people in their 20s filing for...