1. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
  2. P

    Methylene Blue On Hairline + Scar Reduction/help?

    Anyone ever used Methylene Blue on hairline? I used to dermastamp aggressively and created scar issue unfortunately. Thus I am looking to minimize/reverse some of that damage if at all possible. Would applying Methylene Blue on areas of the scalp where I created scar tissue, be helpful? (wound...
  3. Geronimo

    Stress Dysregulates Lung Function

    Anger, stress, dysregulation produces wear and tear on the lung How stress influences disease: Study reveals inflammation as the culprit I think we can all piece this together here.
  4. haidut

    Niacinamide May Treat Fibrotic Eye Disease And Prevent Vision Loss

    A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This...
  5. md_a


    I think excess cortisol-aldosterone- mineralocorticoid activation trough angiotensin system are main players in balding by cytokine activation and progressing to fibrosis. Focusing on TGF-β₁, which shuts off the anagen phase of the hair cycle, and 11β-HSD₁ expression should fix to the problem...
  6. Kingpinguin

    Covid-19 Causing Irreversible Lung Fibrosis

    Coronavirus ‘like a combination of SARS and AIDS’ Autopsies of the people dead in wuhan shows ”irreversible” lung damage even if the patient recovers. Pulmonary fibrosis is permanent scarring of the lung tissue that can leave the patient chronically out of breath. The paper described an...
  7. Mauritio

    Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO

    Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...
  8. Adrenaline

    Lidocaine Inhibits Collagen Accumulation (Fibrosis)

    Collagen accumulates with aging and causes fibrosis. Although this study only highlights aged donors, it shows that lidocaine antagonizes the pro-fibrotic effects of IGF-1, TGF Beta-1, collagen proteins and inhibits collagen accumulation. Lidocaine impairs proliferative and biosynthetic...
  9. haidut

    Vitamin E Restores Cardiac Health After Heart Attack

    A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the...
  10. haidut

    Supplementation With (long Chain) Saturated Fats Protects Liver From Alcohol

    As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...
  11. haidut

    PUFA (metabolites) Drive Heart Failure And Possibly Diabetes

    Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...
  12. haidut

    Daily Aspirin Reduces By 37% Risk Of Fatty Liver Progressing Into Cirrhosis

    Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin "a promising anti-fibrotic strategy for NAFLD". This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the...
  13. haidut

    Heart Failure Deaths On The Rise In Younger US Adults

    The bad news for younger Americans just keep on coming. In addition to lethal cancers, diabetes, stroke, CVD, infertility, etc now we can add yet another "old man" disease to the list of banes inflicting the "young". The "Young" Have Now Become The Old Heart failure is a condition traditionally...
  14. haidut

    Epidemic Of NAFLD And NASH In Young People

    Yet another sad reminder of just how much the health of the average person has declined over the last 20 years. They truly are becoming the "new old". The "Young" Have Now Become The Old If these trends are not reversed or at least slowed down, we may start seeing people in their 20s filing for...
  15. L

    Risk Of Fibrosis With Serotonin Antagonists

    We know that drugs with the 5-ht2b agonist effect have been linked with fibrosis risk. Which of the serotonin antagonists are safe to use for long term in this regard? I have read that cyproheptadine, pizotifen, lisuride, metergoline, ritanserin, ketanserin are safe. Any more?
  16. haidut

    Morphostasis Theory Of Immunity Confirmed - Body Treats Heart Attack Like Viral Infection

    Peat has touched upon his views of the immune system in several articles, mostly related to autoimmune disease. In his view, the role of the immune system is not so much to "attack" foreign pathogens that threaten the organism, but is more akin to sanitation workers who clean up trash and other...
  17. haidut

    Pulmonary Fibrosis May Be Caused By Endotoxin (LPS)

    Ray spoken and written at length about endotoxin (LPS) and its role in virtually all chronic conditions. Mianstream medicine vehemently denies that LPS is an issue, except possibly for people with liver disease. But in thoses cases, the claim is that endotoxin may cause fever and diarrhea but...
  18. P

    Aspirin Alleviates Cardiac Fibrosis In Mice By Inhibiting Autophagy

    Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy. - PubMed - NCBI Acta Pharmacol Sin. 2017 Apr;38(4):488-497. doi: 10.1038/aps.2016.143. Epub 2017 Feb 20. Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy. Liu PP1, Liu HH2, Sun SH3, Shi XX2, Yang WC2, Su...
  19. haidut

    Alcohol Mostly Benign For The Liver, Causing Injury Requires Endotoxin (LPS)

    Peat wrote in one of his articles that alcohol is getting a bad reputation for causing all sorts of liver disease and even liver cancer, but alcohol by itself is fairly neutral for the liver and that the role of PUFA, iron and endotoxin is being neglected by mainstream medicine. The study below...
  20. P

    Statins May Exert Beneficial Effects Through A Pathway Other Than It's Cholesterol Lowering Action

    Was surprised when saw a study showing statins have positive effects on bones, did a bit of searching and it turned out that it has some positive action,generally, through inhibiting rho kinase, which also is protective against heart disease. Im not promoting statin use at all(for obvious...