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fibrosis

  1. aliml

    Stearic acid attenuates profibrotic signalling in idiopathic pulmonary fibrosis

    Background and objective: Lipid metabolism dysregulation has been implicated in the pathogenesis of IPF; however, the roles of most lipid metabolites in lung fibrosis remain unexplored. Therefore, we aimed to identify changes in lipid metabolites in the lung tissues of IPF patients and determine...
  2. haidut

    Vitamin D, reducing fat oxidation may treat lung fibrosis, COVID-19

    Pulmonary fibrosis, regardless of etiology, is considered invariably a progressive and fatal disease. Despite this official story, behind the scenes several pharma companies are running clinical trials with several anti-fibrotic agents and the results so-far demonstrate that the condition is...
    • haidut
    • Thread
    • aldosterone angiotensin cholecalciferol covid-19 fibrosis lung renin sars-cov-2 vitamin d
    • Replies: 19
    • Forum: Scientific Studies
  3. haidut

    How lipolysis may damage organs such as the heart

    It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...
    • haidut
    • Thread
    • adipocytes debris fibrosis heart lipolysis mitochondria ros
    • Replies: 0
    • Forum: Scientific Studies
  4. haidut

    Upregulated serotonin synthesis may be a biomarker for breast cancer

    Once again, the available evidence contradicts the popular myth promoted by public health agencies that serotonin is the "happiness hormone". One only needs to talk to a person on serotonergic (SSRI) drugs for a few minutes to realize just how "happy" those people are as a result of their...
    • haidut
    • Thread
    • biomarker breast cancer fibrosis melatonin predictive serotonin ssri synthesis
    • Replies: 0
    • Forum: Scientific Studies
  5. haidut

    Vitamin D (topical) safe and effective for removing scars

    A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical/heat burns, radiation, etc. As the study says, the typical treatment is with...
    • haidut
    • Thread
    • cholecalciferol fibrosis keloid scars skin vitamin d vitamin d3
    • Replies: 11
    • Forum: Scientific Studies
  6. Mauritio

    Bromantane reduces liver fibrosis by 60%, kidney fibrosis by 50%

    This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis. I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not...
    • Mauritio
    • Thread
    • bromantane dopamine fibrosis kidney fibrosis ladasten liver fibrosis nafld nash np-160
    • Replies: 17
    • Forum: Scientific Studies
  7. Mauritio

    Dutasteride / Finasteride cause fibrosis of the penis and prostate; decrease androgen receptors, increase estrogen receptors

    If you contemplate taking finasteride/ dutasteride read this study. Or just ask yourself:" do I potentially want a fibrotic penis ?" Another reason not to take dutasteride or finasteride: they cause fibrosis of the penis and prostate and increase the expression of the estrogen receptor and...
  8. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
    • haidut
    • Thread
    • fao ffa fibrosis heart keto ketone low-carb mitochondria sirt7 sirtuin
    • Replies: 16
    • Forum: Scientific Studies
  9. P

    Methylene Blue On Hairline + Scar Reduction/help?

    Anyone ever used Methylene Blue on hairline? I used to dermastamp aggressively and created scar issue unfortunately. Thus I am looking to minimize/reverse some of that damage if at all possible. Would applying Methylene Blue on areas of the scalp where I created scar tissue, be helpful? (wound...
  10. Geronimo

    Stress Dysregulates Lung Function

    Anger, stress, dysregulation produces wear and tear on the lung How stress influences disease: Study reveals inflammation as the culprit I think we can all piece this together here.
    • Geronimo
    • Thread
    • fibrosis lungs stress
    • Replies: 1
    • Forum: Stress
  11. haidut

    Niacinamide May Treat Fibrotic Eye Disease And Prevent Vision Loss

    A great new study that demonstrated nicotinamide (NAM) may also have anti-fibrotic effects in addition to its positive effects on maintaining favorable NAD/NADH ratio and redox balance. The mechanism of action of NAM was inhibition of the TGF-β pathway and overall reduction of inflammation. This...
    • haidut
    • Thread
    • eyes fibrosis inflammation niacinamide prevent treat vitamin b3
    • Replies: 5
    • Forum: Scientific Studies
  12. md_a

    RENIN-ANGIOTENSIN-ALDOSTERONE SYSYTEM And HAIR LOSS PROCESS

    I think excess cortisol-aldosterone- mineralocorticoid activation trough angiotensin system are main players in balding by cytokine activation and progressing to fibrosis. Focusing on TGF-β₁, which shuts off the anagen phase of the hair cycle, and 11β-HSD₁ expression should fix to the problem...
    • md_a
    • Thread
    • aldosterone angiotensin cytokines fibrosis hair loss mineralocorticoid progesterone renin tgf-b1
    • Replies: 114
    • Forum: Scientific Studies
  13. Kingpinguin

    Covid-19 Causing Irreversible Lung Fibrosis

    Coronavirus ‘like a combination of SARS and AIDS’ Autopsies of the people dead in wuhan shows ”irreversible” lung damage even if the patient recovers. Pulmonary fibrosis is permanent scarring of the lung tissue that can leave the patient chronically out of breath. The paper described an...
    • Kingpinguin
    • Thread
    • covid-19 fibrosis lung lung disease
    • Replies: 236
    • Forum: Society
  14. Mauritio

    Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO

    Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...
    • Mauritio
    • Thread
    • diabetes endotoxin fibrosis nitric oxide no obesity serotonin tlr4 tph tph inhibitor
    • Replies: 4
    • Forum: Scientific Studies
  15. Adrenaline

    Lidocaine Inhibits Collagen Accumulation (Fibrosis)

    Collagen accumulates with aging and causes fibrosis. Although this study only highlights aged donors, it shows that lidocaine antagonizes the pro-fibrotic effects of IGF-1, TGF Beta-1, collagen proteins and inhibits collagen accumulation. Lidocaine impairs proliferative and biosynthetic...
  16. haidut

    Vitamin E Restores Cardiac Health After Heart Attack

    A great study that gives vitamin E a much deserved exposure in mainstream media. A few years ago, vitamin E was lambasted by the press for failing to prevent prostate cancer and heart attacks. Yet, upon a more careful look, it quickly becomes evident that those trials were handicapped from the...
    • haidut
    • Thread
    • alpha tocopherol damage fibrosis heart heart attack heart muscle inflammation ischemia lessen prevent scarring tocopherol vitamin e
    • Replies: 4
    • Forum: Scientific Studies
  17. haidut

    Supplementation With (long Chain) Saturated Fats Protects Liver From Alcohol

    As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...
    • haidut
    • Thread
    • alcohol damage dysbiosis dysfunction endotoxin ethanol fibrosis lcsfa liver lps protective reverse saturated fat sfa sibo tlr4 treatment
    • Replies: 1
    • Forum: Scientific Studies
  18. haidut

    PUFA (metabolites) Drive Heart Failure And Possibly Diabetes

    Over the years I have posted a number of studies on the roles of PUFA metabolites such as prostaglandins and leukotrienes in many chronic conditions including cancer, Alzheimer, Parkinson, ALS, MS, CVD, etc. For those that are new to this issue, COX enzymes are responsible for prostaglandin...
    • haidut
    • Thread
    • 12/15lox alox15 cause cvd diabetes drive fibrosis heart attack heart failure inflammation lipoxygenase lox pufa
    • Replies: 4
    • Forum: Scientific Studies
  19. haidut

    Daily Aspirin Reduces By 37% Risk Of Fatty Liver Progressing Into Cirrhosis

    Another great study about aspirin. What I particularly like about this study is that one of the authors is calling aspirin "a promising anti-fibrotic strategy for NAFLD". This is the first time I have heard a doctor refer to aspirin as anti-fibrotic chemical. Peat mentioned aspirin as one of the...
    • haidut
    • Thread
    • aspirin cirrhosis fatty liver fibrosis liver nafld prevent reduce risk
    • Replies: 5
    • Forum: Scientific Studies
  20. haidut

    Heart Failure Deaths On The Rise In Younger US Adults

    The bad news for younger Americans just keep on coming. In addition to lethal cancers, diabetes, stroke, CVD, infertility, etc now we can add yet another "old man" disease to the list of banes inflicting the "young". The "Young" Have Now Become The Old Heart failure is a condition traditionally...
    • haidut
    • Thread
    • fibrosis heart failure millenials mortality rates reversing rising trend young
    • Replies: 6
    • Forum: Scientific Studies
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