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Vitamin D (topical) safe and effective for removing scars

haidut

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Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical/heat burns, radiation, etc. As the study says, the typical treatment is with cortisol injections, however the effectiveness is less than 10%, and the only other option is cosmetic surgery, which of course leaves scars of its own and can hardly be considered a "solution". Humble vitamin D may come to the rescue and even though the study used injections of the vitamin into the scar, topical administration of vitamin D has also been found to achieve high skin concentrations. The dosage used in the study was 200,000 of vitamin D3, and all that was needed was 3-4 sessions of such treatment. The mechanism of action, as expected, was the antifibrotic effects of vitamin D, which I have discussed many times in my posts. The study abstract does not mention timing/duration but considering mos doctors prescribe 50,000 IU weekly, this suggests the study used the 200,000 IU once monthly and as such the treatment duration was 3-4 months. There is no reason why the same effects cannot be achieved with daily treatments using lower doses, which means daily topical administration of 10,000 IU - 15,000 IU of vitamin D3 (higher dose than the 200,000 / 30 in order to account for absorption of less than 100% through the skin) should be able to achieve similar results.

Role of vitamin D in treatment of keloid - PubMed
The Role of Vitamin D in Keloid Scar Treatment

"...A recent study in the Journal of Cosmetic Dermatology examines the safety and efficacy of using vitamin D intralesional injection for the treatment of keloid scars. Treating keloid scars continue to be a particular challenge for dermatologists due to the scars oversized nature, continued growth, and difficult treatment. While intralesional corticosteroid injection is considered first-line treatment for keloids, a recent study in the Journal of Cosmetic Dermatology1 (JCD) examined vitamin D efficacy treating keloids using intralesional injection. Vitamin D slows the progression of tissue fibrosis by keloid fibroblasts and inhibits collagen synthesis in dermal fibrosis, according to the study, making the vitamin a key player in cell proliferation and differentiation. The study, which evaluated the efficacy of intralesional injection of vitamin D in the treatment of keloids, both clinically and ultrasonically, included 40 patients with keloids. Patients were injected weekly with intralesional vitamin D at a dose of 0.2 ml (200,000 IU) per 1 cm lesion. The keloid scars were evaluated before and after treatment with the Vancouver Scar Scale (VSS) and by a high-resolution ultrasound using B mode. Study patients received 3 to 4 sessions. Results showed a statistically significant reduction in VSS after treatment with the vitamin injection (p value ≤0.001) along with a highly significant improvement in ultrasonic keloid scar thickness post-treatment (P value ≤0.001). From this data, study investigators concluded that intralesional vitamin D is a safe and effective treatment of keloid scares. Additionally, ultrasound is useful in assessing keloid improvement after treatment."
 

youngsinatra

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Feb 3, 2020
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Location
Frankfurt, Germany
I have a product with vitamin D3 dissolved in MCT oil in the form of a dropper.

How much approximately would be absorbed through the skin in your opinion and expertise?
 

haidut

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Thread starter
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Mar 18, 2013
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Location
USA / Europe
I have a product with vitamin D3 dissolved in MCT oil in the form of a dropper.

How much approximately would be absorbed through the skin in your opinion and expertise?

Nobody knows for sure what the topical absorption is as it depends on solvent, skin area, skin location, individual health, etc. If there is only MCT oil in it, then I'd say 15%-20% absorption is probably a reasonable expectation.
 

Don.M

New Member
Joined
Oct 3, 2020
Messages
2
Nobody knows for sure what the topical absorption is as it depends on solvent, skin area, skin location, individual health, etc. If there is only MCT oil in it, then I'd say 15%-20% absorption is probably a reasonable expectation.
Is there any advantage to using D3 (Cholecalciferol) topically vs a pill? Perhaps no need to supplement K2 if D3 is used topically? I would also appreciate if you could clarify what vitamin D supplementation, if any, and what version, is recommended if you can’t get enough sunlight. And what cofactors, like K2, you need to take. I’ve read many of your posts and listened to podcasts with you and Ray but I’m unfortunately still confused. So much information! 😁
 

LeeLemonoil

Member
Joined
Sep 24, 2016
Messages
2,695
A caveat and comment:
A keloid scar behaves or better is different then a residual hypertrophic scar („normal“ scarring)
Different cellular mechanisms and alteration.

D seems to regulate the keloid MoA - I doubt it would necessarily achieve functional tissue Back from a hypertrophic scar - but it’s worth trying
 

sun-maid

Member
Joined
Sep 19, 2019
Messages
183
A neat human study, which demonstrates that topical treatment with vitamin D may treat even large scars that have been present on the skin for years. Many people have such scars as a result of surgery, trauma, chemical/heat burns, radiation, etc. As the study says, the typical treatment is with cortisol injections, however the effectiveness is less than 10%, and the only other option is cosmetic surgery, which of course leaves scars of its own and can hardly be considered a "solution". Humble vitamin D may come to the rescue and even though the study used injections of the vitamin into the scar, topical administration of vitamin D has also been found to achieve high skin concentrations. The dosage used in the study was 200,000 of vitamin D3, and all that was needed was 3-4 sessions of such treatment. The mechanism of action, as expected, was the antifibrotic effects of vitamin D, which I have discussed many times in my posts. The study abstract does not mention timing/duration but considering mos doctors prescribe 50,000 IU weekly, this suggests the study used the 200,000 IU once monthly and as such the treatment duration was 3-4 months. There is no reason why the same effects cannot be achieved with daily treatments using lower doses, which means daily topical administration of 10,000 IU - 15,000 IU of vitamin D3 (higher dose than the 200,000 / 30 in order to account for absorption of less than 100% through the skin) should be able to achieve similar results.

Role of vitamin D in treatment of keloid - PubMed
The Role of Vitamin D in Keloid Scar Treatment

"...A recent study in the Journal of Cosmetic Dermatology examines the safety and efficacy of using vitamin D intralesional injection for the treatment of keloid scars. Treating keloid scars continue to be a particular challenge for dermatologists due to the scars oversized nature, continued growth, and difficult treatment. While intralesional corticosteroid injection is considered first-line treatment for keloids, a recent study in the Journal of Cosmetic Dermatology1 (JCD) examined vitamin D efficacy treating keloids using intralesional injection. Vitamin D slows the progression of tissue fibrosis by keloid fibroblasts and inhibits collagen synthesis in dermal fibrosis, according to the study, making the vitamin a key player in cell proliferation and differentiation. The study, which evaluated the efficacy of intralesional injection of vitamin D in the treatment of keloids, both clinically and ultrasonically, included 40 patients with keloids. Patients were injected weekly with intralesional vitamin D at a dose of 0.2 ml (200,000 IU) per 1 cm lesion. The keloid scars were evaluated before and after treatment with the Vancouver Scar Scale (VSS) and by a high-resolution ultrasound using B mode. Study patients received 3 to 4 sessions. Results showed a statistically significant reduction in VSS after treatment with the vitamin injection (p value ≤0.001) along with a highly significant improvement in ultrasonic keloid scar thickness post-treatment (P value ≤0.001). From this data, study investigators concluded that intralesional vitamin D is a safe and effective treatment of keloid scares. Additionally, ultrasound is useful in assessing keloid improvement after treatment."

Do you think it can help with Eczema, skin redness and other skin problem? @haidut
 

Pina

Member
Joined
Oct 12, 2020
Messages
5,686
I had a swollen gland in my neck at the weekend. I robbed 2 drops of vitamin D (4000 iu) on it. When I woke the next morning the gland was back to normal. I was pretty impressed.
 

teds

Member
Joined
Jun 5, 2017
Messages
277
Might try this
Let us know how it goes. It mentions 200000iu- how will you get this? I was reading it thinking, ‘ok, so I dump a few bottles of D3 on my skin’..

The studies mention intralesional injections into keloid scar..

Anyway - Pls let us know if what you try is effective! :)
 

superhappy

Member
Joined
Jun 14, 2021
Messages
15
So would applying a copious amount of D3 on your scalp after using a dermastamp or dermapen help regrow hair?
 
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