Momado965

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Don't think they are comparable. Cypro is a direct serotonin receptor antagonist while I am not aware of any androgen actually being able to bind a serotonin receptor. Testosterone, progesterone and allopregnanolone may act as functional 5-HT3 antagonists but only there and indirectly. So, don't think cyproheptadine can be replaced reliably by any steroid.

Damn it.
 

haidut

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Momado965

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Jing

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@haidut if putting 11 keto dht on the penis how many drops can be absorbed at once ? Would putting pansterone and 11keto dht together on the penis still be absorbed?
 

Yody

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Aug 23, 2019
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I also would like to know!
 

Yody

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Wolfman9193

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Aug 27, 2019
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I've been dosing 11-keto for about a week and here's what I noticed. Been dosing 2 drop 2x/day

More frequent bowels. I always had some sort of digestive issue going on. High serotonin was suspected here. 11-Keto improves digestion/bowels better than Cyproheptadine (in my experience). Next thing I noticed was more frequent chubs or random wood. Before 11-Keto I would never get these. Could be from increased DHT or maybe decreased stress hormones. I'm also able to handle more coffee. I used to drink 1/2 a cup and feel the cortisol and other stress response, now I am back up to 2 cups a day. I did Intermittent fasting last summer and believe it damaged by body/response to stress hormones. 11-keto definitely helping.
 

Wolfman9193

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Also should note my appetite is also up. Another sign of stress hormones being down. Slight weight gain but I think it's cause of my body not running off of stress hormones as much and trying to rely on Thyroid. (Being honest but also been eating like ***t) I take 1-2 drops of Tyronene a day but may be too early to notice anything.
 

iPeat

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Oct 27, 2018
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I experimented on my lab rat using 11-KDHT orally (2mg in a gelatin capsule) yesterday. One hour after administration the subject experienced extreme fatigue. So much so that he took a nap. The subject generally finds it impossible to nap, even if he really tries/wants to. He was extremely fatigued for the remainder of the day and had about 6 or 7 bowel movements that continued into this morning. This morning the test subject arose with flu-like symptoms which are subsiding with time. No fever, just feelings of being hot then cold, chills, scratchy throat, sour stomach, brain fog, etc.

The subject has been administered 11-KDHT topically in the past, on nearly every surface of the body testable, to no noticeable effect.

Has anyone else noticed this effect of oral administration?
 

Wolfman9193

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Digestion/# of bowel movements back down and noticing more bruxism (sign of increased cortisol) with 5mg/day... unsure why
 

Bilal

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Dec 26, 2019
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As promised, I am releasing a steroid that may be of interest to some people on the forum. It is a variation of the well-known steroid DHT that Peat has written about and I have also posted quite a few studies on. The steroid belongs to the group of the so-called keto-steroids and AFAIK this is the first time it is being sold to the general public. Some websites sell a steroid called 11-ketotestosterone (11-keto T), which is a precursor to 11-keto DHT. Both 11-keto T and 11-keto DHT are legal within the USA (for now). How long will that legal status persist I simply don't know.
The few studies that have been done on 11-keto DHT demonstrates it has the same androgenic activity / potency as DHT, but its role in mammals is virtually unknown. In fish however, 11-keto T and 11-keto DHT are the primary androgens driving the male phenotype. What is known is that 11-keto DHT has a much longer half-life than DHT and as such has the potential to exert androgenic activity even with very sporadic administration (2-3 times a week) as opposed to the daily administration needed with steroids like T and DHT. The half-life of 11-keto DHT appears to be on the order of 36 hours.

2016 New Investigator: Karl Storbeck | Bioanalysis Zone
"...We have discovered a novel pathway for the metabolism of the steroid 11β-hydroxyandrostenedione (11OHA4), a major product of human steroidogenesis which has been ignored for decades. We showed that 11OHA4 is the precursor to the potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT). Using a combination of UPLC–MS and UPLC–MS/MS techniques we confirmed the existence of a number of novel steroids in this pathway. We have since shown that 11KDHT is as potent as DHT, previously considered to be most potent natural androgen, a finding which has significant implications for our understanding of androgen dependent diseases such as castration-resistant prostate cancer and diseases of androgen excess, such as congenital adrenal hyperplasia and polycystic ovary syndrome."

11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant... - PubMed - NCBI
"...The pathway was validated in the androgen-dependent prostate cancer cell line, LNCaP. Androgen receptor (AR) transactivation studies showed that while 11KT and 11OHDHT act as a partial AR agonists, 11KDHT is a full AR agonist exhibiting similar activity to DHT at 1nM. Our data demonstrates that, while 11OHA4 has negligible androgenic activity, its metabolism to 11KT and 11KDHT yields androgenic compounds which may be implicated, together with A4 and DHEA(S), in driving CRPC in the absence of testicular T."

An investigation into the androgenic activity of 11-ketotestosterone and 11-ketodihydrotestosterone
"...This study is the first to show that 11KT and 11KDHT are metabolized at a significantly lower rate in both cell lines when compared to T and DHT, respectively, thus likely accounting for their apparent increased activity. The data clearly shows that 11KT and 11KDHT are potent and efficacious androgens, comparable to T and DHT. Most importantly, the findings highlight the fact that not only can 11KT and 11KDHT activate the androgen axis, and in so doing drive cell growth, but that these steroids have the potential to remain active for longer than T and DHT due to a reduced rate of metabolism. Collectively, the data demonstrates that 11KT and 11KDHT likely play a vital, but overlooked, role in the development and progression of CRPC."

"...A slower metabolic rate was observed in the VCaP cells. For example, DHT and T substrates were depleted in 24 hours in LNCaP cells, while complete metabolism of DHT and T substrates in VCaP cells was only achieved after 48 hours (Fig. 3.16). Nevertheless, the same trend was observed between the respective steroids. DHT was metabolised signicantly faster (63% in 12 hours) than the same concentration of 11KDHT (17% in 12 hours). After 24 hours, only 9% of DHT remained, compared to 60% of 11KDHT. While DHT was completely metabolised after 48 hours, 21% of the 11KDHT remained detectable after 72 hours."

The units listed on the label are just for measurement purposes. They do not indicate suggested or optimal dose. Please note that similar to the products sold by companies like BluePeptides, this product is for lab/research use only. The product can be ordered from the link below:
IdeaLabs Online Store - Worldwide Ordering And Delivery - Laboratory Research Chemicals

*******************************************************************************
11-keto DHT, also known as 11-ketoandrostanolone, is a keto-steroid present naturally in small amounts in a mammals body. Its physiological role in mammals is currently unknown, however, in fish 11-keto DHT is the primary androgen driving the male phenotype. In vitro research suggests that 11-keto DHT binds to and activates the androgen receptor with the same potency / affinity as the mammalian androgen DHT.

Drops per container: about 250
Each drop contains the following ingredients:

11-keto DHT: 1 mg

Other ingredients: DMSO, ethanol
*******************************************************************************
Hello new to this website how could i buy this of you specifically heard from someone that you sell it
 

SrankAnimal

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Dec 29, 2019
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4
I’ve been taking this 3 days. Honestly I feel like my libido has tanked. Gonna stop and retry in a couple days but surely this isn’t right ?
 

Bilal

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Dec 26, 2019
Messages
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I’ve been taking this 3 days. Honestly I feel like my libido has tanked. Gonna stop and retry in a couple days but surely this isn’t right ?
On paper its meant to increase it are u taking any other hormone altering things
 

SrankAnimal

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Dec 29, 2019
Messages
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On paper its meant to increase it are u taking any other hormone altering things
I’m taking androsterone and pansterone.
I started all at the same time. It’s only day 3. I’ve noticed better mood and more desire for ice cream.
Not sure if the ice cream (sugar need) is the high training load 5-6 days a week or placebo (seeing other people post it)

The phallus of my rat is not as hanging as before. If before was 6.5in and now 4in unless post workout
 

opethfeldt

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Mar 12, 2017
Messages
490
I’ve been taking this 3 days. Honestly I feel like my libido has tanked. Gonna stop and retry in a couple days but surely this isn’t right ?
Probably lower estrogen. It's a common side effect of DHT to lose libido. Often, it's either estrogen getting too low from the DHT itself, or testosterone going down from suppression and creating a low estrogen state that way. I'd either lower the dose or increase estrogen with something like DHEA and the libido issues should resolve.
 

SrankAnimal

New Member
Joined
Dec 29, 2019
Messages
4
Probably lower estrogen. It's a common side effect of DHT to lose libido. Often, it's either estrogen getting too low from the DHT itself, or testosterone going down from suppression and creating a low estrogen state that way. I'd either lower the dose or increase estrogen with something like DHEA and the libido issues should resolve.
I thought the same thing, because I'm always consuming organic veggies and mushrooms. In the gym, most people can see a pronounce bulge and now not there.
I'm taking pansterone. Tried it on the testiscles. I've tried to up the eggs.
But I'm going to reduce the kdht11 to 1mg from 2-4mg and maybe do it strictly once a day.
Was thinking about this while at the gym today. Thank bud, more confirmation on the slower route
 
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