androgens

Objectives: Dihydrotestosterone (DHT) is known as the main cause of androgenetic alopecia (AGA). We previously reported that sulforaphane (SFN), a compound extracted from broccoli, promotes hair regeneration in ob/ob mice by lowering plasma DHT levels. The aim of this study was to assess whether...

Our dachshund (now 4 and a half) was castrated pretty early as a pup. One of his testicles hadn't descended properly and we were advised by the vet to get it done as there was a risk of cancer the longer it was left. I know now this was probably an error and we should have gotten a second...

A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much...

So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...

I am posting this simply as a response to the many hateful comments I got in regards to my discussion of testosterone as a progestin. Peat also alluded to the fact that testosterone has activity on the progesterone receptor and is likely safer as a "progestin" than the synthetic progestins being...

It is well-known that in animal studies acetaminophen has a potent anti-androgenic and feminizing effect. In some animal models it also reliably causes autism-like symptoms. Given its widespread use and heavy marketing by hospitals, especially to pregnant women (due to its lack of effect on...

While these studies only focus on the wasting syndrome in HIV/AIDS patients, the pathology of the wasting is virtually the same in other cachectic conditions including cancer, Cushing, sepsis, etc. If DHT does get approved by the FDA for muscle wasting, we may finally see a change in attitude in...

Just like the other vitamin products we have released, this product does not really need any introduction to anybody familiar with Peat's work. So, unlike other products of ours, there won't be as many references listed in support of this product but I think even the few ones below are enough to...

There is a particular user on this forum who had been proposing fasting as a way of "resetting the receptors". The idea of course being that if you have low levels of a hormone you will experience an increased number of the proteins that the hormone interacts with. I am highly skeptical of this...

I have posted quite a few studies showing the effects of various fatty acids on estrogen, androgen and glucocorticoid synthesis. This study shows that both PUFA and MUFA are strong inhbitors of 5-AR, with PUFA being the more potent inhibitors and inhibition potency being strongly dependent on...

Increasing 5-AR activity has received a lot of interest lately due to its therapeutic effects on mood disorders as well as issues with excess cortisol (5-AR deactivates cortisol). Unfortunately, the official story is that there are no freely available compounds that can stimulate 5-AR activity...

The study found that all tested androgens, as well as progesterone were calcium channel blockers and 5b-DHT was the most potent. Androsterons was next, and it was equipotent to DHEA and testosterone. While the dose used in the study was high, the authors believe that the same effects may be...

As I posted in one of the androsterone threads, studies in the first half of the 20th century discovered hypocholesteremic and pyrogenic effects of androsterone and many animal models and also in humans. However, the direct mechanism for these effects of androsterone was not elucidated by these...

This interesting in relation to the femur bone growth. SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. Abstract CONTEXT: SHBG regulates free sex steroid levels, which in...

"Previous studies with different results have suggested that total and bioavailable testosterone levels are modified by physical exercise. Such changes may be related to modifications in cortisol levels and could be reflected in some urine androgens. To determine how weight lifting training may...

Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids, it takes anywhere in the range of 6-12 months for this increase to be reflected in blood levels...

There is great interest in the blogosophere in writing about and supplementing with the pineal hormone melatonin. Ray has written about the dangers of melatonin, but there is enough contradictory research to confuse people. This study shows that another pineal hormone, which ALWAYS rises...

Ray wrote quite a bit on the topic of estrogen as a causative factor in demyelination and progesterone / pregnenolone as remyelinating agents. I posted an animal study recently on using DHT to completely reverse the pathology of the MS that model...

Adnrosterone is a downstream metabolite of DHT and just like DHT it is a 5-AR derived steroid. What is even more interesting is that androsterone is not just a metabolite of DHT but can be converted back to DHT as needed in target tissues where DHT is needed. In fact, androsterone has at least 2...

If you ask a neurologist she/he will tell you that nobody knows the cause of MS, and if you ask about the role of hormones the doctor will probably give you blank stare and flatly deny that they have a causative or therapeutic role (except for cortisol as acute treatment). Ray, on the other...