Fractality
Member
- Joined
- Jan 23, 2016
- Messages
- 772
While it may not build size, I'm assuming it will build strength due to its androgenicity.
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Any idea how this would effect signalling around 5-AR? If this is administered would the body convert less Testosterone to DHT via 5-AR and push it down the Estrogen route due to the body thinking DHT was already at decent levels or would it reduce 5-AR conversion on the whole? Apologies if my reasoning is a little off...
It should keep it from converting into estrogen. I find 11-keto DHT to be stronger anti-aromatase than anastrozole, at least for me.
While it may not build size, I'm assuming it will build strength due to its androgenicity.
is this sourced from China?
Crazy exciting. Have you by any chance communicated with a certain anti-PUFA guru about these keto-steroids, @haidut?
If so, any comments?
@haidut
How do you find it stronger anti-aromatase than anastrozole. Do you judge by a lowering of typical estrogenic effects like water retention? Is there no estrogen "rebound" after the 11-keto DHT wears off? Did you experience anti-estrogen effects from regular DHT?
In bodybuilding circles I think arimidex is seen as the weakest AI, with aromasin or letrozole being preferred. Have you tried those? Letrozole should be the strongest AI, I'm wondering how that would compare with DHT or the 11-keto DHT
Would rats be better taking in AM or PM. or doesn't it matter because of longer half life?
is this sourced from China?
Haidut, your stuff is amazing, please let me know what I can do to help expand your business!
Haidut, should men be worried about suppression if we discontinue use?
This looks to be amazing as I took propecia in the past. This is the antithesis 10 years later!!
I don't think 11-keto DHT is suppressive. If anything, I posted a study showing DHT stimulates its own synthesis.
@haidut, this study below says that DHT is clearly suppressive. Is 11-keto DHT somehow different compared with plain DHT in this regard?
Effects of 10 days administration of percutaneous dihydrotestosterone on the pituitary-testicular axis in normal men.
"The results of this study demonstrate that 10-days DHT administration has an inhibitory effect on the hypothalamo-pituitary-testicular axis in normal men."
Sure, at a dose of 250mg daily DHT (or any other steroid, except pregnenolone and progesterone) will become suppressive.
"...Dihydrotestosterone (DHT) was administered percutaneously in a dose of 125 mg twice daily for 10 days to 12 normal men. Basal plasma levels of testosterone (T), 17 beta-estradiol (E2), and LH were measured every 2 days in these men and every 5 days in subjects from a control group receiving placebo."
Not even sure what studies like this aim to achieve. Such a dose of DHT is absurd and has no basis in vitro or in vivo animal studies.
It should be noted that the effective absorption of DHT from the hydrocalcholic gel found in Andractim is only 10%. So effectively, these folk were getting only 25mg a day. Could you estimate what the safe dosage range might be for DHT?
Also, will someone with estrogen dominance be more or less liable to get suppressed from the same dose of DHT?
Applied directly on the testicles, DHT should stimulate T synthesis from pregnenolone and DHEA.