I did take a look and unfortunately the audio wouldn't play. I browsed a bit and it indicated both B6 and the active form can be toxic at a high dose. That it's generally better to dose the active form at 10-20mg.When in doubt, I pretty much always go with what Ray Peat advises. Go here: bioenergetic search , type in p5p and the audio comes up that I remembered. Double click on the paragraph to activate the audio.