Bacteriophages gave me leaky gut...

peateats1

Member
Joined
Apr 3, 2013
Messages
172
Does anyone have a solution for this? My gut is constantly leaking endotoxin and I don't know how to fix this. It's pretty much destroyed my health.
This started right after I took bacteriophages in October of 2019. I had a stool test done and it looks fine for the most part. The only "bad" bacteria was detected in a throat swab I had done. It's enterobacter, which I'm currently treating with Bactrim. It's not helping my lps symptoms at all, so I don't think it's my main issue really.
I had a cyrex labs lps blood test done and it did show elevated endotoxin. Also, any time I'm active at all, even grocery shopping, I turn pale/yellowish, and look sickly, which I know is caused by endotoxins leaking into my blood stream.
So far I've tried xifaxan and other antibiotics to lower bacterial load which helps for a while sometimes, but then I'm back in the same inflamed boat. I've tried colostrum, gelatin, bone broth, suppressing my tsh to near zero, progesterone, niacinamide, multiple carrot salads per day, probiotics, aspirin, low iron(I didn't eat red meat for a year), sunbathing everyday for a whole summer, red light therapy, and nothing helps enough to end this nightmare. These things are keeping me from spiraling into severe health problems but they aren't fixing the root of it all.
Some things that have helped mildly are xifaxan, cyproheptadine, vitamin A(I seem to have a serious deficiency or something), and now vitamin E succinate(I just started this and it calms me so much)
My main symptoms are: purple/red extremities from poor circulation(like people with pots), high blood pressure and heart rate, chest and vein/vascular pain, poor muscle tone, low energy, depression, low body temp, low potassium (I'm guessing from elevated renin due to endotoxin poisoning), just overall feeling sick and fatigued, red angiomas appearing all over my skin, high prolactin and serotonin.
I had none of those symptoms until the phage induced nightmare.
My diet is great.......cottage cheese(no gums), occasionally boiled spinach, boiled mushrooms, carrot salad, gelatin, oxtail bone broth, eggs, oj, coconut water, chocolate, etc.


So I guess with all that said, is there something I'm missing here? Do bacteriophages cause leaky gut permanently? I have zero ecoli in my intestines thanks to the phages....could that cause leaky gut? Do bacteriophages stay in the intestine forever? How do I fix this?
 

TheBeard

Member
Joined
May 16, 2018
Messages
2,015
Have you tried Lugol's iodine?

It's pretty potent at killing bacterium and fungi, it works well for me.
 

professor_sue

Member
Joined
Jan 7, 2017
Messages
22
Have you tried Lugol's iodine?

It's pretty potent at killing bacterium and fungi, it works well for me.
This is good info to have! I had bought Lugol's iodine at the start of the virus crisis last February 2020, but have not taken any of it. How much do you take and/or would you recommend? There are no dosage recommendations on the bottle. I have a hypothyroid diagnosis and am currently taking 120 mg of Armour Thyroid. I have wanted to take it but I just don't have a clue about how many drops, etc. Any insights would be awesome. Thank you!
 
Last edited:

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,290
If your gut's leaky it's because the gut lining is not healthy. Colonocytes get up to 90% of their energy from butyrate, which is produced by gut bacteria and found in certain foods. So if you're killing off gut bacteria, your only source is food, and that may not be enough.
 

TheBeard

Member
Joined
May 16, 2018
Messages
2,015
This is good info to have! I had bought Lugol's iodine at the start of the virus crisis last February 2020, but have not taken any of it. How much do you take and/or would you recommend? There are no dosage recommendations on the bottle. I have a hypothyroid diagnosis and am currently taking 120 mg of Armour Thyroid. I have wanted to take it but I just don't have a clue about how many drops, etc. Any insights would be awesome. Thank you!

Half dropper of a 2% solution in 1.5L bottle of apple juice sipped through the day.
 

professor_sue

Member
Joined
Jan 7, 2017
Messages
22
Half dropper of a 2% solution in 1.5L bottle of apple juice sipped through the day.
Great, thank you! I appreciate it. I'll give it a shot. Anything that can help boost my thyroid will be helpful to boost my overall metabolism I would imagine.
 

rei

Member
Joined
Aug 6, 2017
Messages
1,265
cholesterol, preg&prog, methylene blue, aspirin, and just to cover all the basics a good multivitamin. Sometimes it is better to take a multivitamin than trying to snipe some aspects that might make others worse.

As specific treatment something like megadosing vitamin c until noticeable diarrhea might be something that shifts the balance towards normal.
 

LLight

Member
Joined
May 30, 2018
Messages
719
Long term betaine supplementation.
Seems to be involved with bile acid production and immune system in the gut.

Betaine (trimethylglycine, an osmolyte) really seems like a wonder nutrients:

Investigation of betaine as a novel psychotherapeutic for schizophrenia

That's weird how digestion seems to be so hard to fix while we should now know all the possible causes and how to remedy them.

Is the problem due to a lack of digestive fluids (gastric juices, bile) or enzymes? This one could imply bad microbiota and inflammatory undigested proteins? Causes: infection, nutrient deficiency or functional issue like a blocked bile-duct?

As this is my current craze, here are somes citations from papers on betaine that I've read recently:









I've also read how oxytocin and vasopressin could be involved in increasing "gastric and duodenum motility via OTR" (in rabbits) and regulating the phasic contraction of the gallbladder during the interdigestive period, which is thought "to be important in stirring the bile, facilitating the bile concentration and preventing the gallstone formation" (still in rabbits). I had also previously read how vasopressin could be involved in bile flow control in rats.

There are also studies during Ramadan showing how gastric acid pH is increased (but the study results might be biased because of all the habits that change during Ramadan).

Moral of the story: don't drink too much or at least between meals (and try to increase intermeal time?) and supplement betaine (which is itself an osmolyte which helps with dehydration)?
 

S-VV

Member
Joined
Jul 23, 2018
Messages
457
Mutaflor or Symbioflor 2 as E. Coli probiotics
Cholestyramine and activated charcoal to adsorb LPS
Milk of magnesia or Cascara as prokinetic if necessary
 

peateats1

Member
Thread starter
Joined
Apr 3, 2013
Messages
172
If your gut's leaky it's because the gut lining is not healthy. Colonocytes get up to 90% of their energy from butyrate, which is produced by gut bacteria and found in certain foods. So if you're killing off gut bacteria, your only source is food, and that may not be enough.
Butyrate is something I hadn't come across, so thank you for posting this! Looking into it just now, it appears to be in higher concentrations in ghee. I'll try adding that to my diet and maybe look into supplementing too.
 

peateats1

Member
Thread starter
Joined
Apr 3, 2013
Messages
172
cholesterol, preg&prog, methylene blue, aspirin, and just to cover all the basics a good multivitamin. Sometimes it is better to take a multivitamin than trying to snipe some aspects that might make others worse.

As specific treatment something like megadosing vitamin c until noticeable diarrhea might be something that shifts the balance towards normal.
I've tried most of those supplements but didn't do so well with pregnenolone as it seemed to increase my estrogen symptoms. Aspirin and progesterone are definitely keepers though...,.methylene blue didn't cause any positive or negative effects for me so I stopped using it.
I'll definitely give the vitamin C a go. It would be helpful to clear stuff out, especially now that I've probably overdone the lactobacillus probiotics 😕
 

peateats1

Member
Thread starter
Joined
Apr 3, 2013
Messages
172
Long term betaine supplementation.
Seems to be involved with bile acid production and immune system in the gut.
I'll look into this a bit more and maybe give it a try! I appreciate the studies, thank you for posting those!
 

peateats1

Member
Thread starter
Joined
Apr 3, 2013
Messages
172
Mutaflor or Symbioflor 2 as E. Coli probiotics
Cholestyramine and activated charcoal to adsorb LPS
Milk of magnesia or Cascara as prokinetic if necessary
I was wondering about using ecoli probiotics, thinking they might help, but I'm too chicken to try them so far lol. I was reading on this forum about people that have used them and had good results, so I may give them a go at some point.
I haven't tried those other supps, so will definitely look into them! Thank you!
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,290
Butyrate is something I hadn't come across, so thank you for posting this! Looking into it just now, it appears to be in higher concentrations in ghee. I'll try adding that to my diet and maybe look into supplementing too.

If you look into supplements, butyrate, butyric acid and butanoic acid are basically the same.
 

Daniil

Member
Joined
Feb 13, 2021
Messages
321
Location
Moscow
Are you sure it's related to phages? Anything else? Any supplements?

I think that phages could destroy some bacteria and instead of them, other, more bad ones began to grow. Perhaps you should try some probiotic. Although Ray says that you need a sterile intestine, it is unlikely that this can be achieved. Even if there are no bacteria, there will be fungi like candida, etc. So I believe that the use of probiotics is justified, you just choose the lesser evil. I think intestinal permeability is the biggest problem that can be, because it causes everything else. However, someone has it, and someone does not. And there seems to be no solution to this problem on the forum. They offer supplements of vitamin A, D, B2, and large doses of C.
 

Bart1

Member
Joined
May 21, 2018
Messages
343
Does anyone have a solution for this? My gut is constantly leaking endotoxin and I don't know how to fix this. It's pretty much destroyed my health.
This started right after I took bacteriophages in October of 2019. I had a stool test done and it looks fine for the most part. The only "bad" bacteria was detected in a throat swab I had done. It's enterobacter, which I'm currently treating with Bactrim. It's not helping my lps symptoms at all, so I don't think it's my main issue really.
I had a cyrex labs lps blood test done and it did show elevated endotoxin. Also, any time I'm active at all, even grocery shopping, I turn pale/yellowish, and look sickly, which I know is caused by endotoxins leaking into my blood stream.
So far I've tried xifaxan and other antibiotics to lower bacterial load which helps for a while sometimes, but then I'm back in the same inflamed boat. I've tried colostrum, gelatin, bone broth, suppressing my tsh to near zero, progesterone, niacinamide, multiple carrot salads per day, probiotics, aspirin, low iron(I didn't eat red meat for a year), sunbathing everyday for a whole summer, red light therapy, and nothing helps enough to end this nightmare. These things are keeping me from spiraling into severe health problems but they aren't fixing the root of it all.
Some things that have helped mildly are xifaxan, cyproheptadine, vitamin A(I seem to have a serious deficiency or something), and now vitamin E succinate(I just started this and it calms me so much)
My main symptoms are: purple/red extremities from poor circulation(like people with pots), high blood pressure and heart rate, chest and vein/vascular pain, poor muscle tone, low energy, depression, low body temp, low potassium (I'm guessing from elevated renin due to endotoxin poisoning), just overall feeling sick and fatigued, red angiomas appearing all over my skin, high prolactin and serotonin.
I had none of those symptoms until the phage induced nightmare.
My diet is great.......cottage cheese(no gums), occasionally boiled spinach, boiled mushrooms, carrot salad, gelatin, oxtail bone broth, eggs, oj, coconut water, chocolate, etc.


So I guess with all that said, is there something I'm missing here? Do bacteriophages cause leaky gut permanently? I have zero ecoli in my intestines thanks to the phages....could that cause leaky gut? Do bacteriophages stay in the intestine forever? How do I fix this?
I’m in the same boat ☹️ Don’t have a solution though..
 

Jennifer

Member
Joined
Jul 8, 2014
Messages
2,411
My diet is great.......cottage cheese(no gums), occasionally boiled spinach, boiled mushrooms, carrot salad, gelatin, oxtail bone broth, eggs, oj, coconut water, chocolate, etc.

Is the cottage cheese cultured and if so, have you tried dairy that doesn’t contain bacterial cultures/isn’t fermented? Could you be sensitive to the gelatin (I’m thinking you meant the powdered kind?) or the starch and/or potential mycotoxins in the chocolate?
 

mostlylurking

Member
Joined
May 13, 2015
Messages
514
Does anyone have a solution for this? My gut is constantly leaking endotoxin and I don't know how to fix this. It's pretty much destroyed my health.
This started right after I took bacteriophages in October of 2019. I had a stool test done and it looks fine for the most part. The only "bad" bacteria was detected in a throat swab I had done. It's enterobacter, which I'm currently treating with Bactrim. It's not helping my lps symptoms at all, so I don't think it's my main issue really.
I had a cyrex labs lps blood test done and it did show elevated endotoxin. Also, any time I'm active at all, even grocery shopping, I turn pale/yellowish, and look sickly, which I know is caused by endotoxins leaking into my blood stream.
So far I've tried xifaxan and other antibiotics to lower bacterial load which helps for a while sometimes, but then I'm back in the same inflamed boat. I've tried colostrum, gelatin, bone broth, suppressing my tsh to near zero, progesterone, niacinamide, multiple carrot salads per day, probiotics, aspirin, low iron(I didn't eat red meat for a year), sunbathing everyday for a whole summer, red light therapy, and nothing helps enough to end this nightmare. These things are keeping me from spiraling into severe health problems but they aren't fixing the root of it all.
Some things that have helped mildly are xifaxan, cyproheptadine, vitamin A(I seem to have a serious deficiency or something), and now vitamin E succinate(I just started this and it calms me so much)
My main symptoms are: purple/red extremities from poor circulation(like people with pots), high blood pressure and heart rate, chest and vein/vascular pain, poor muscle tone, low energy, depression, low body temp, low potassium (I'm guessing from elevated renin due to endotoxin poisoning), just overall feeling sick and fatigued, red angiomas appearing all over my skin, high prolactin and serotonin.
I had none of those symptoms until the phage induced nightmare.
My diet is great.......cottage cheese(no gums), occasionally boiled spinach, boiled mushrooms, carrot salad, gelatin, oxtail bone broth, eggs, oj, coconut water, chocolate, etc.


So I guess with all that said, is there something I'm missing here? Do bacteriophages cause leaky gut permanently? I have zero ecoli in my intestines thanks to the phages....could that cause leaky gut? Do bacteriophages stay in the intestine forever? How do I fix this?
For your consideration:
Although this article pertains specifically to Bactrim, many antibiotics along with many pharmaceutical drugs cause functional thiamine deficiency: Bactrim: An Anti-Folate, Anti-Thiamine, Potassium Altering Drug - Hormones Matter

You are showing the symptoms of gastrointestinal beriberi. Your gut is damaged, your ability to absorb thiamine is damaged, your ability to functionally utilize thiamine is damaged from the antibiotics. This does not just "go away" after some time has passed. You should investigate this issue. Here is an article: When SIBO & IBS-Constipation are just unrecognized thiamine deficiency

Sources for information:
also the search engine on this forum; search for "thiamine"

Here are a couple of videos for your consideration:

View: https://www.youtube.com/watch?v=nuIhjlFYYZY


and:

View: https://www.youtube.com/watch?v=BkKmiZkiEPI
 
Similar threads
Thread starter Title Forum Replies Date
M Bacteriophages To Improve Digestive Issues Digestion, Gut Flora 2
pauljacob Pregnenolone Gave Me Vertigo Pregnenolone 10
A Aspirin Gave Me Permanent Tinnitus, Help Ask For Help or Advice 56
Twohandsondeck White Rice Gave Me Tooth Sensitivity Miscellaneous Health Discussions 8
Deadpool 1 Drop Of Thyroid Gave Me A Panic Attack? Ask For Help or Advice 38
Gadsie I'm Scared My Paleo Past Gave Me Colon Cancer, Should I Get A Colonoscopy? Diet 15
BingDing Maybe The Best Speech John F Kennedy Ever Gave The Ray Peat Forum Lounge 3
J Gave Up Protein Drinks And Feeling A Lot Better (ammonia Smell Also Gone) Ask For Help or Advice 13
ecstatichamster Gave Blood Yesterday And Already Feel Strikingly Better Experiments 3
B Warning-dont-take-drugs-your-doctor-gave-you-until-you-read Articles 1
natedawggh Kiehl's Skin Care Products Gave Me Erectile Dysfunction Sexuality 9
Y Doctor Gave Me Slow Release T3, Do I Take It? T3 10
Y Doc Gave Me Mirtazapine For Sleep, Is It Safe For Few Weeks Use? Insomnia, Sleep Issues 43
L Ray Peat Diet Gave Me A Fatty Liver? Ask For Help or Advice 169
haidut Metabolism May Be The Primordial Tool That Gave Rise To Life Science 2
paper_clips43 Paleo maybe gave me sinus infection. Experimenting peat diet Diet 6
B Borderline Hypothyroid, Histamine Intolerance? Leaky Gut? Hydrogen Sulfide SIBO?? Need Help Digestion, Gut Flora 24
Lokzo Cordyceps Reduces Leaky Gut - PUBMED Scientific Studies 12
M How To Treat Leaky Blood-brain-barrier If One Is Sensitive To Caffeine Pill? Ask For Help or Advice 3
B 30 Day Coconut Water Fast To Detox And Help Ulcers, Leaky Gut, Hypothyroidism,liver/kidney Function? Ask For Help or Advice 13
Mito Fructose Promotes Leaky Gut, Endotoxemia, And Liver Fibrosis Articles & Scientific Studies 21
Hans Zinc Carnosine Improves Exercise Induced Leaky Gut Scientific Studies 23
D Fighting Candida, Food Sensitivities / Leaky Gut, Brain Fog, Ocular Migraines, Acetaldehyde Supplements, Pharmaceutical Drugs 18
L Uncongugated Bilirubin As A Cause Of Leaky Gut Digestion, Gut Flora 10
A Venous Leak / Leaky Vein Syndrome Male Issues 21
Broken man Guidelines For Leaky Gut, High Lactate, Damaged Intestine, Celiac Disease Digestion 95
I Leaky Gut And Circulation Problems Digestion 23
P Ray Peat's Take On Leaky Gut? Digestion 12
E Effects Of Aspirin On Leaky Gut Aspirin 25
Y Is Taking L-Glutamine For Leaky Gut Peat Friendly? Amino Acids 6
S Cyproheptadine Prevents Exercise-induced Leaky Brain Scientific Studies 13
haidut Medicine Finally Admits Leaky Gut Is A "real" Disease Digestion, Gut Flora 2
J Aspirin and Leaky Gut Aspirin 30
J What Are The Treatments For Leaky Gut? Digestion, Gut Flora 14
D Dairy, and leaky gut Working Through Milk Issues 11

Similar threads

Top