Copper deficiency edema

Pina

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Joined
Oct 12, 2020
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266
Why did I not know this before? If anyone can elaborate on the study below please feel free. This is a rat study. I wonder if it translates to humans? Could salt sensitivity be caused by a copper deficiency?


I stumbled on this whilst researching my continuing poor muscular skeletal health. Weak muscles coupled with hypothyroid symptoms, a recent increase in edema upon supplementing thyroid got me wondering what else I could be missing. I'd never associated copper with edema. My face looks like those old photos of myxedema. I hope these symptoms are reversible. My spine is pretty damaged. I will start supplementing copper to see if things improve. Will also get kidney function test done as soon as possible, perhaps before supplementing. Its pointless demanding a thyroid test from my doctors, according to them my thyroid is fine based on tsh of 1.8, my hypo symptoms are disregarded. Dr peat has emphasised the loss of copper in hypothyroid persons but the connection to salt sensitivity is surprising, presuming this applies to humans and not just rats.
 

Linnechka

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Joined
Jun 12, 2020
Messages
6
Why did I not know this before? If anyone can elaborate on the study below please feel free. This is a rat study. I wonder if it translates to humans? Could salt sensitivity be caused by a copper deficiency?


I stumbled on this whilst researching my continuing poor muscular skeletal health. Weak muscles coupled with hypothyroid symptoms, a recent increase in edema upon supplementing thyroid got me wondering what else I could be missing. I'd never associated copper with edema. My face looks like those old photos of myxedema. I hope these symptoms are reversible. My spine is pretty damaged. I will start supplementing copper to see if things improve. Will also get kidney function test done as soon as possible, perhaps before supplementing. Its pointless demanding a thyroid test from my doctors, according to them my thyroid is fine based on tsh of 1.8, my hypo symptoms are disregarded. Dr peat has emphasised the loss of copper in hypothyroid persons but the connection to salt sensitivity is surprising, presuming this applies to humans and not just rats.
Hey Pina, Are your muscles weak or do they fatigue almost instantly? I was struggling with really terrible muscle fatigue (basically an average set of stairs or 2 mins on a bike was enough to exhaust) especially in my lower legs. I've been hypo for a while and taking T3 to help with that. I was also getting leg edema bad enough that at times it felt like the skin was going to rip. I went to several doctors who couldn't find anything wrong with me. I do eat 1oz oysters daily, so I get my copper every day, but the thing that made the biggest difference for me was several months taking higher daily doses of B1 (thiamine). (I took about 300mg per day, though I know some people go higher to knock out deficiency symptoms). Maybe worth looking into the symptoms of beriberi to see if you have a thiamine deficiency?
 

Pina

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Joined
Oct 12, 2020
Messages
266
Hey Pina, Are your muscles weak or do they fatigue almost instantly? I was struggling with really terrible muscle fatigue (basically an average set of stairs or 2 mins on a bike was enough to exhaust) especially in my lower legs. I've been hypo for a while and taking T3 to help with that. I was also getting leg edema bad enough that at times it felt like the skin was going to rip. I went to several doctors who couldn't find anything wrong with me. I do eat 1oz oysters daily, so I get my copper every day, but the thing that made the biggest difference for me was several months taking higher daily doses of B1 (thiamine). (I took about 300mg per day, though I know some people go higher to knock out deficiency symptoms). Maybe worth looking into the symptoms of beriberi to see if you have a thiamine deficiency?
Yes, I am fatigued and my muscles are floppy. I have been supplementing thiamine, in fact, my thiamax order arrived today and I took one this morning. I am very hypo now. Freezing. Topical t3 does help but I seem to need a lot of it. Adrenalin is causing issues as a result. I have been using thiamine for a long time at high doses so it seems unlikely that this could be a thiamine issue. However, thanks for the suggestion and I will continue with thiamine and perhaps increase it. Copper deficiency is remarkably similar to thiamine deficiency in some ways

Neurologic and sensory-related symptoms​

Copper plays an important role in the production and maintenance of myelin, a substance that coats nerves and facilitates the communication of signals throughout the nervous system (neurotransmission). A copper-containing enzyme also converts the neurotransmitter dopamine to the neurotransmitter norepinephrine. Copper deficiency may result in:

  • Peripheral neuropathy: Weakness, numbness and pain can be felt, usually in your hands and feet.
  • Myelopathy: Spinal cord defects that can result in diminishing body function, pain, and weakness.
  • Improper synthesis of neurotransmitters: For example, inadequate dopamine may inhibit feelings of pleasure or understanding rewards.
  • Weak muscles (hypotonia): Low muscle tone can result in a "floppy" appearance.
 
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