Mauritio
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- Joined
- Feb 26, 2018
- Messages
- 5,669
What ratio though?clarify the butter
melt both the clarified butter and stearic acid together
that's about it, at least that's what I'm going to do.
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What ratio though?clarify the butter
melt both the clarified butter and stearic acid together
that's about it, at least that's what I'm going to do.
This may be a reason why this works:
Dietary stearic acid regulates mitochondria in vivo in humans
Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not.
We previously showed that the fatty acid stearic acid (C18:0) signals via a dedicated pathway to regulate mitofusin activity and thereby mitochondrial morphology and function in cell culture. Whether this pathway is poised to sense changes in dietary intake of C18:0 in humans is not known. We show here that C18:0 ingestion rapidly and robustly causes mitochondrial fusion in people within 3 h after ingestion. C18:0 intake also causes a drop in circulating long-chain acylcarnitines, suggesting increased fatty acid beta-oxidation in vivo. This work thereby identifies C18:0 as a dietary metabolite that is sensed by our bodies to control our mitochondria. This could explain part of the epidemiological differences between C16:0 and C18:0, whereby C16:0 increases cardiovascular and cancer risk whereas C18:0 decreases both
And this:
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway
Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function.
Relevant to this idea, mitochondrial function is impaired in diabetic individuals.
Furthermore, the expression of Opa-1 and mitofusins, proteins of the mitochondrial fusion machinery, is dramatically altered in obese and insulin-resistant patients.
Given the role of insulin in the control of cardiac energetics, the goal of this study was to investigate whether insulin affects mitochondrial dynamics in cardiomyocytes.
Confocal microscopy and the mitochondrial dye MitoTracker Green were used to obtain three-dimensional images of the mitochondrial network in cardiomyocytes and L6 skeletal muscle cells in culture.
Three hours of insulin treatment increased Opa-1 protein levels, promoted mitochondrial fusion, increased mitochondrial membrane potential, and elevated both intracellular ATP levels and oxygen consumption in cardiomyocytes in vitro and in vivo.
Consequently, the silencing of Opa-1 or Mfn2 prevented all the metabolic effects triggered by insulin. We also provide evidence indicating that insulin increases mitochondrial function in cardiomyocytes through the Akt-mTOR-NFκB signaling pathway. These data demonstrate for the first time in our knowledge that insulin acutely regulates mitochondrial metabolism in cardiomyocytes through a mechanism that depends on increased mitochondrial fusion, Opa-1, and the Akt-mTOR-NFκB pathway.
Metabolites produced from fiber includes some important fatty acids including stearic acid. With gut issues the microbiome will become imbalanced and metabolites production will be affected.
Multi-omics Analysis of Gut Microbiota and Metabolites in Rats With Irritable Bowel Syndrome
One of the few metabolites that is lower in rats with IBS is stearic acid.
So for people with gut issues, adding stearic acid might compensate the metabolites that are produced by the gut and signals the body that everything is okay so you start losing abdominal fat.
Thanks, will try this once I have sime stearic acidclarify the butter
melt both the clarified butter and stearic acid together
that's about it, at least that's what I'm going to do.
Ah yeah I've seen that one... The problem is that we don't know if it's pure stearic acid because most stearic acid that's being sold is 50% stearic acid and 50% palmitic acid...This one, just searched for Food Grade Steric Acid on Amazon- https://www.amazon.com/Lbs-Stearic-...food+grade+stearic+acid&qid=1576269283&sr=8-1
Ah yeah I've seen that one... The problem is that we don't know if it's pure stearic acid because most stearic acid that's being sold is 50% stearic acid and 50% palmitic acid...
Do you think eating st. acid long term (providing it worked well initially for fat loss) would have some downsides?According the the croissant diet guy, that’s a feature, not a bug. Saturated fat induces mitochondrial ROS in the adipocytes, making them transiently (physiologically) insulin resistant, so that they do not uptake more fatty acids, and instead burn their own. Of course, since fat stays on the bloodstream, by the Randle Cycle, it will decrease glucose oxidation, which will translate to a higher BS reading.
What were they like?I loved the brain benefits
just quicker, easier to think, more awareWhat were they like?
Thanks
He could've just waterfasted a whole month instead of eating junk.
Well, you can buy wheat grain, and mill it with a grain mill. That is, if you have one. Sometimes, a coffee bean burr grinder can be used for that purpose as well.I have been looking for unenriched flour, its illegal to sell and import it in Canada. Anyone have a lead?
just quicker, easier to think, more aware
Metabolites produced from fiber includes some important fatty acids including stearic acid. With gut issues the microbiome will become imbalanced and metabolites production will be affected.
Multi-omics Analysis of Gut Microbiota and Metabolites in Rats With Irritable Bowel Syndrome
One of the few metabolites that is lower in rats with IBS is stearic acid.
So for people with gut issues, adding stearic acid might compensate the metabolites that are produced by the gut and signals the body that everything is okay so you start losing abdominal fat.
that's an interesting hypothesis, thank you!
I'm a little slow here. Dow does taking stearic acid cause one to lose abdominal fat? Sorry, TLDR on that link.
Nutritional Signaling via Free Fatty Acid Receptors
The gut has receptors detecting various fatty acids to regulate metabolism and inflammation.
My hypothesis is that ingesting stearic acid will signal the body to upregulating metabolism and reduce inflammation with effects like blood glucose reduction talked about here Dietary Stearic Acid Reduces Visceral Fat By 70% And Increases Lean Mass.
I am actually looking to buy a Bartaza Encore. If a burr grinder can double up as a grain mill I would consider buying a more expensive one. If you have anymore insight please share.Well, you can buy wheat grain, and mill it with a grain mill. That is, if you have one. Sometimes, a coffee bean burr grinder can be used for that purpose as well.