Why Does Tamoxifen Seem To Cause Low Libido And E.D

[Libra guy]

If it boosts t and dht levels why is it i don't feel the effects i even took viagra 50mg and it didn't seem affective while using tamoxifen i gear it can get t levels up to the 8 -900 plus range test that high a man should be like a 17 year old again why am i not feeling it

 

[redsun]

If it boosts t and dht levels why is it i don't feel the effects i even took viagra 50mg and it didn't seem affective while using tamoxifen i gear it can get t levels up to the 8 -900 plus range test that high a man should be like a 17 year old again why am i not feeling it

Many users complain of lower libido and ED from estrogen lowering substances. Even if its raising androgens, if you have problems with your neurotransmitters you will have low libido and ED.

 

[haidut]

If it boosts t and dht levels why is it i don't feel the effects i even took viagra 50mg and it didn't seem affective while using tamoxifen i gear it can get t levels up to the 8 -900 plus range test that high a man should be like a 17 year old again why am i not feeling it

Tamofixen is a SERM - i.e. a synthetic estrogen that has SOME anti-estrogenic effects in SOME tissues, but remains a potent synthetic estrogen and especially so in the gonadal system. Why would you use this toxic drug?? Just because bodybuilders use it left and right does not make it OK. Also, not sure where you get the info on raising T, DHT, etc. There is evidence tamoxifen actually damages the reproductive system and lowers T, probably due to its potent estrogen agonist effects in the testis.
Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics
"...We found that a single dose of tamoxifen less than 10% of the mean dose used for recombination induction, caused adverse effects to the testis and to the reproductive endocrine system that persisted long-term. These data raise significant concerns about the widespread use of tamoxifen induction of recombination, and highlight the importance of including appropriate controls in all pathophysiological studies using this means of induction."

https://www.researchgate.net/public...trate_on_reproductive_parameters_of_male_dogs
"...Tamoxifen negatively affected testis size and libido (P<0.01), and decreased prostatic volume (P<0.01) and testosterone concentrations during treatment. Semen quality deteriorated to nadir values (P<0.01) approximately one spermatic cycle after treatment and returned to pre-treatment values on the second cycle after treatment in all the dogs, except one young oligoazoospermic dog, in which the sperm count was higher ( P<0.01 ) at that time. No side effects were observed and fertility was conserved at the end of the study. Tamoxifen acted more like an agonist than antagonist on the gonadal axis and, therefore, upon both the prostate and testis."

@redsun

 

[redsun]

Tamofixen is a SERM - i.e. a synthetic estrogen that has SOME anti-estrogenic effects in SOME tissues, but remains a potent synthetic estrogen and especially so in the gonadal system. Why would you use this toxic drug?? Just because bodybuilders use it left and right does not make it OK. Also, not sure where you get the info on raising T, DHT, etc. There is evidence tamoxifen actually damages the reproductive system and lowers T, probably due to its potent estrogen agonist effects in the testis.
Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics
"...We found that a single dose of tamoxifen less than 10% of the mean dose used for recombination induction, caused adverse effects to the testis and to the reproductive endocrine system that persisted long-term. These data raise significant concerns about the widespread use of tamoxifen induction of recombination, and highlight the importance of including appropriate controls in all pathophysiological studies using this means of induction."

https://www.researchgate.net/public...trate_on_reproductive_parameters_of_male_dogs
"...Tamoxifen negatively affected testis size and libido (P<0.01), and decreased prostatic volume (P<0.01) and testosterone concentrations during treatment. Semen quality deteriorated to nadir values (P<0.01) approximately one spermatic cycle after treatment and returned to pre-treatment values on the second cycle after treatment in all the dogs, except one young oligoazoospermic dog, in which the sperm count was higher ( P<0.01 ) at that time. No side effects were observed and fertility was conserved at the end of the study. Tamoxifen acted more like an agonist than antagonist on the gonadal axis and, therefore, upon both the prostate and testis."

@redsun

Ah so its actually negatively affecting androgens. Thanks haidut. So thats prob why OP is getting those issues.

 

[Libra guy]

Tamofixen is a SERM - i.e. a synthetic estrogen that has SOME anti-estrogenic effects in SOME tissues, but remains a potent synthetic estrogen and especially so in the gonadal system. Why would you use this toxic drug?? Just because bodybuilders use it left and right does not make it OK. Also, not sure where you get the info on raising T, DHT, etc. There is evidence tamoxifen actually damages the reproductive system and lowers T, probably due to its potent estrogen agonist effects in the testis.
Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system: implications for inducible transgenics
"...We found that a single dose of tamoxifen less than 10% of the mean dose used for recombination induction, caused adverse effects to the testis and to the reproductive endocrine system that persisted long-term. These data raise significant concerns about the widespread use of tamoxifen induction of recombination, and highlight the importance of including appropriate controls in all pathophysiological studies using this means of induction."

https://www.researchgate.net/public...trate_on_reproductive_parameters_of_male_dogs
"...Tamoxifen negatively affected testis size and libido (P<0.01), and decreased prostatic volume (P<0.01) and testosterone concentrations during treatment. Semen quality deteriorated to nadir values (P<0.01) approximately one spermatic cycle after treatment and returned to pre-treatment values on the second cycle after treatment in all the dogs, except one young oligoazoospermic dog, in which the sperm count was higher ( P<0.01 ) at that time. No side effects were observed and fertility was conserved at the end of the study. Tamoxifen acted more like an agonist than antagonist on the gonadal axis and, therefore, upon both the prostate and testis."

@redsun

I tried it because i heard it boosts t levels similar to clomid but had no idea it was this harsh what should i do now

 

[TomS]

Just read about Tamoxifen
Book title: Over-the-Counter Natural Cures Take Charge of Your Health in 30 Days with 10 Lifesaving Supplements for under 10 by Shane Ellison

Tamoxifen is known commercially as Nolvadex. It’s the gold standard in chemotherapy for breast cancer. But what a drug does biologically and what a drug does according to pharmaceutical advertising are often two distinctly different things. To my surprise, I learned that the tamoxifen cash cow wasn’t performing like the industry wanted. Patients who took it were dying from cancer at a much faster rate than without it.

As a medicinal chemist, my job was to fix the “little cancer problem of tamoxifen.”Initially, tamoxifen was thought to stop cancer by displacing estrogen, oneof the hormones that helped it grow. As time progressed, though, researchers learned that tamoxifen acted just like the cancer fertilizer by mimick ingestrogen. The end result was a biochemical environment favorable to cancer growth among users of tamoxifen. My task was made clear: design “knockoffs”that are effective (at blocking estrogen) without causing cancer. My attempt to design safer tamoxifen alternatives was unsuccessful.

And after one year, the project was ended. However, access to tamoxifen wasn’t. It remained on the market. Even today, it’s advertised and pushed by doctors as a first line of defense against breast cancer. But science and anyone who’s been unfortunate enough to take tamoxifen can tell you that this isn’t something you want to swallow in an attempt to beat cancer. The National Cancer Institute has recently begun to warn that “tamoxifen increases the risk of two types of cancer that can develop in the uterus:endometrial cancer, which arises in the lining of the uterus, and uterine sarcoma,which arises in the muscular wall of the uterus. Like all cancers, endometrial cancer and uterine sarcoma are potentially life-threatening.”113

The risk of these types of cancers triples with the use of tamoxifen, while other types—such asliver and breast cancer—are just as likely.Tamoxifen is so potent that it has been listed as a cancer-causing substancein the Department of Health and Human Services’ Report on Carcinogens. Thisreport is a scientific and public health document firstordered by Congress in 1978 to educate the public and health professionals about the many cancers induced by chemicals in the home, workplace, general environment, and fromthe use of certain drugs!114This brings me to my third universal cancer truth: tamoxifen is nota safeoption for women battling breast cancer. But don’t expect this failing drug—or any other chemotherapy agents—to be pulled from the market. Despite their mustard gas–like toxicity, chemotherapy drugs will continue to be pushed onvulnerable patients, thanks to what I call “chemotherapy life support".

 

[Libra guy]

Many users complain of lower libido and ED from estrogen lowering substances. Even if its raising androgens, if you have problems with your neurotransmitters you will have low libido and ED.

Does estrogen affect neurotransmitters

 

[redsun]

Does estrogen affect neurotransmitters

Yes of course just like testosterone and dht and basically any hormone. But read haiduts post I believe its irrelevant here in your case you likely were lowering your androgens which caused your problems.

 

[Dino D]

Many users complain of lower libido and ED from estrogen lowering substances. Even if its raising androgens, if you have problems with your neurotransmitters you will have low libido and ED.

what problems with neurotransmiters do you suspect in this context and what to do?

 

[redsun]

what problems with neurotransmiters do you suspect in this context and what to do?

You mean if you are taking steroids or other proven androgen boosting substances and still have poor libido/ED? Could be low dopamine (thus high prolactin, killing libido), or dopamine adrenaline balance is heavily tilted towards adrenaline. Zinc usually helps this by reducing noradrenaline. This would mean your are stuck with sympathetic overactivity which kills libido. So in short lack of dopamine or too much noradrenaline/adrenaline, serotonin...

My recommendations in general folic acid, vitamin C, active B6, proteins high in arginine are good. Zinc can be good if you need to reduce excess noradrenaline.

So you would likely see benefit from raising dopamine. Maybe something simple like mucuna pruriens may be enough for you but I believe @Hans has some articles with his own suggestions on his website and perhaps posted on the forum directly as well.

Actually here is a link where he goes more in depth into ED/libido and neurotransmitters and things to do:

Erectile dysfunction Part 1: the solution for your neurotransmitters » MenElite

 

[Jing]

I tried it because i heard it boosts t levels similar to clomid but had no idea it was this harsh what should i do now

If you are willing to take these drugs why don't you just inject testosterone??

 

[Jing]

My recommendations in general folic acid, vitamin C, active B6, proteins high in arginine are good. Zinc can be good if you need to reduce excess noradrenaline.

I remember you mentioning folic acid and b6 before, I've tried folic acid due to your recommendations but I always end up getting bad insomnia on folic acid I will wake up in the middle of the night and just cannot get back to sleep why would folic acid do this? Raising histamine?? Also active b6 makes me feel kinda sick and dizzy? Kind of like travel sickness feeling??

 

[redsun]

I remember you mentioning folic acid and b6 before, I've tried folic acid due to your recommendations but I always end up getting bad insomnia on folic acid I will wake up in the middle of the night and just cannot get back to sleep why would folic acid do this? Raising histamine?? Also active b6 makes me feel kinda sick and dizzy? Kind of like travel sickness feeling??

Sounds like it can be histamine related for you. Usually people with elevated histamine will react badly to histamine raising substances. Folic acid helps retain histidine and promote higher histamine but its also used for BH4 which is necessary for dopamine, serotonin, nitric oxide. And yeh active B6 will acutely raise histamine and too high histamine is involved in motion sickness its generally dopaminergic as well. Seems to me you are likely an individual with elevated histamine. Regardless did these substances positively affect libido/ED or no?

In your case histamine may be all fine or even elevated but dopamine is low.

 

[Jing]

Sounds like it can be histamine related for you. Usually people with elevated histamine will react badly to histamine raising substances. Folic acid helps retain histidine and promote higher histamine but its also used for BH4 which is necessary for dopamine, serotonin, nitric oxide. And yeh active B6 will acutely raise histamine and too high histamine is involved in motion sickness its generally dopaminergic as well. Seems to me you are likely an individual with elevated histamine. Regardless did these substances positively affect libido/ED or no?

In your case histamine may be all fine or even elevated but dopamine is low.

I do feel I have elevated histamine as I have travel sickness I have suffered with this all my life and allergies I get stuffy nose alot and itchy eyes . I feel b6 after I have ejaculated helps with refractory period and raises my libido abit, folic acid I'm not too sure but I haven't been able to give it a proper try because of insomnia, I think I do notice more vascular hands on folic acid though. Yh I'm pretty sure I'm low dopamine

 

[redsun]

I do feel I have elevated histamine as I have travel sickness I have suffered with this all my life and allergies I get stuffy nose alot and itchy eyes . I feel b6 after I have ejaculated helps with refractory period and raises my libido abit, folic acid I'm not too sure but I haven't been able to give it a proper try because of insomnia, I think I do notice more vascular hands on folic acid though. Yh I'm pretty sure I'm low dopamine

Yeh you definitely have elevated histamine. Yeh it will promote nitric oxide along with vitamin C via BH4 which will increase vascularity. Yeh the B6 is likely lowering prolactin a bit improving recovery from the refractory period but because its worsening your histamine problem not really a good solution.

 

[Jing]

Yeh you definitely have elevated histamine. Yeh it will promote nitric oxide along with vitamin C via BH4 which will increase vascularity. Yeh the B6 is likely lowering prolactin a bit improving recovery from the refractory period but because its worsening your histamine problem not really a good solution.

Any other solutions instead of these to reduce prolactin and increase vascularity? I've tried vitamin e to try reduce prolactin but I've never noticed a benefit or a negative from vitamin e.

 

[redsun]

Any other solutions instead of these to reduce prolactin and increase vascularity? I've tried vitamin e to try reduce prolactin but I've never noticed a benefit or a negative from vitamin e.

Vitamin C is generally dopaminergic and helps lower histamine and as I said would promote nitric oxide. So lots of high vitamin c fruits would be good. Zinc also lowers prolactin. You may see benefit from eating more liver to help control your histamine by providing more copper and methylating nutrients. Liver and lots of high vitamin C fruits may help balance out your high histamine levels though copper doesnt directly lower prolactin.

 

[Jing]

Vitamin C is generally dopaminergic and helps lower histamine and as I said would promote nitric oxide. So lots of high vitamin c fruits would be good. Zinc also lowers prolactin. You may see benefit from eating more liver to help control your histamine by providing more copper and methylating nutrients. Liver and lots of high vitamin C fruits may help balance out your high histamine levels though copper doesnt directly lower prolactin.

Ok tbh Im not sure I can eat liver lol discussing to me.

 

[Attakai]

Never tried tamoxifen, but torem which is similar boosts my libido

 

[Libra guy]

You mean if you are taking steroids or other proven androgen boosting substances and still have poor libido/ED? Could be low dopamine (thus high prolactin, killing libido), or dopamine adrenaline balance is heavily tilted towards adrenaline. Zinc usually helps this by reducing noradrenaline. This would mean your are stuck with sympathetic overactivity which kills libido. So in short lack of dopamine or too much noradrenaline/adrenaline, serotonin...

My recommendations in general folic acid, vitamin C, active B6, proteins high in arginine are good. Zinc can be good if you need to reduce excess noradrenaline.

So you would likely see benefit from raising dopamine. Maybe something simple like mucuna pruriens may be enough for you but I believe @Hans has some articles with his own suggestions on his website and perhaps posted on the forum directly as well.

Actually here is a link where he goes more in depth into ED/libido and neurotransmitters and things to do:

Erectile dysfunction Part 1: the solution for your neurotransmitters » MenElite

I do sweat alot so its possible im low in zinc and i haven't been on vitamin C in a while i try them and see if they help