Letrozole For Estrogen Tissue?

Sospian

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May 31, 2020
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After coming off gear a few years back I never fully recovered. I developed mild gynecomastia and a varicocele after PCT and then more or less lived through my early 20s with a limp ****.

During the Summer of 2019 I experimented with a trace mineral called Boron. To my surprise, within a few days my erection quality returned strong than ever before - for around about two weeks. After that it faded and Boron hasn't given me the same effect since (although it still does help).

I assumed this was a entirely down to Testosterone levels as my testicles grew by a very noticeable difference during the very short period of time I was on it.

In October I did a bloods. My T was 440ng/dl and E2 was on the lower end, so I decided to re-run PCT. My Testosterone levels peaked at around 1,450ng/dl yet I still seemed to have issues. My testicles were humongous. I mean, I couldn't even get anywhere close to closing my legs, yet the libido barely improved and EQ didn't shift at all. This baffled the hell out of me as all my other bloods were fine other than my higher-range prolactin levels and E2 (which was from the Clomid). The varicocele also become unbearably painful, although likewise I assumed it was just down the vein being choked harder. As my T and E2 dropped back down, so did the pain.

Since then I've been raising my T up naturally and am currently around 800ng/dl despite the varicocele. That being said, EQ still isn't the best and libido is unreliable. I have a very healthy lifestyle, although could never work out why Boron worked like magic the first time I used it. Cabergoline helped increase libido but not EQ, and Viagra didn't help with EQ either.

While asking a guy on Reddit for his take on varicoceles, he made the weirdest claim I had heard as of yet - Varicoceles are related to Estrogen. This confused me for a little bit so I asked him where he got his information from, and that's when he told me about Ray Peat.

I've been lurking here for the past two weeks sucking up all the information I can, and there seems to be two main theories to what cause varicoceles: the first being pelvic floor dysfunction (as PEGym also suggested) with the other being Estrogen.
I spent a lot of time working on pelvic floor tightness pre-lockdown and could almost do the front-splits although saw no progress with the varicocele or EQ.

Progeststerone cream directly on the veins & Vitamin E, as well as red-light therapy also saw no improvement. Actually, I've probably tried most things here, which is why I'm moving on to my next step: Letrozole.

Letrozole is an aromatese inhibitor that I formerly used to nuke old gynecomastia, although unfortunately it rebounded (which I believe to be because of my low T at the time).

This time I'm going to be very interested in the results. I know exercise will be hard on my joints for a good few weeks but it's worth the experiment.

Failing any success with Letrozole, I plan to move on to low-dose Proviron, which probably means I will have to run Nolvadex after to avoid any sort of HPTA shutdown. I'm pretty sure someone here posted that they managed to fix their varicocele within a few days of using Proviron.

So my question is: before I go and splash money of this drug, could Letrozole work in removing tissue estrogens from all over the body such as within varicoceles?

Cheers guys
 

redsun

Member
Joined
Dec 17, 2018
Messages
1,873
After coming off gear a few years back I never fully recovered. I developed mild gynecomastia and a varicocele after PCT and then more or less lived through my early 20s with a limp ****.

During the Summer of 2019 I experimented with a trace mineral called Boron. To my surprise, within a few days my erection quality returned strong than ever before - for around about two weeks. After that it faded and Boron hasn't given me the same effect since (although it still does help).

I assumed this was a entirely down to Testosterone levels as my testicles grew by a very noticeable difference during the very short period of time I was on it.

In October I did a bloods. My T was 440ng/dl and E2 was on the lower end, so I decided to re-run PCT. My Testosterone levels peaked at around 1,450ng/dl yet I still seemed to have issues. My testicles were humongous. I mean, I couldn't even get anywhere close to closing my legs, yet the libido barely improved and EQ didn't shift at all. This baffled the hell out of me as all my other bloods were fine other than my higher-range prolactin levels and E2 (which was from the Clomid). The varicocele also become unbearably painful, although likewise I assumed it was just down the vein being choked harder. As my T and E2 dropped back down, so did the pain.

Since then I've been raising my T up naturally and am currently around 800ng/dl despite the varicocele. That being said, EQ still isn't the best and libido is unreliable. I have a very healthy lifestyle, although could never work out why Boron worked like magic the first time I used it. Cabergoline helped increase libido but not EQ, and Viagra didn't help with EQ either.

While asking a guy on Reddit for his take on varicoceles, he made the weirdest claim I had heard as of yet - Varicoceles are related to Estrogen. This confused me for a little bit so I asked him where he got his information from, and that's when he told me about Ray Peat.

I've been lurking here for the past two weeks sucking up all the information I can, and there seems to be two main theories to what cause varicoceles: the first being pelvic floor dysfunction (as PEGym also suggested) with the other being Estrogen.
I spent a lot of time working on pelvic floor tightness pre-lockdown and could almost do the front-splits although saw no progress with the varicocele or EQ.

Progeststerone cream directly on the veins & Vitamin E, as well as red-light therapy also saw no improvement. Actually, I've probably tried most things here, which is why I'm moving on to my next step: Letrozole.

Letrozole is an aromatese inhibitor that I formerly used to nuke old gynecomastia, although unfortunately it rebounded (which I believe to be because of my low T at the time).

This time I'm going to be very interested in the results. I know exercise will be hard on my joints for a good few weeks but it's worth the experiment.

Failing any success with Letrozole, I plan to move on to low-dose Proviron, which probably means I will have to run Nolvadex after to avoid any sort of HPTA shutdown. I'm pretty sure someone here posted that they managed to fix their varicocele within a few days of using Proviron.

So my question is: before I go and splash money of this drug, could Letrozole work in removing tissue estrogens from all over the body such as within varicoceles?

Cheers guys

If you want your **** to work optimally you need to focus on nitric oxide. Especially if your androgens are normal trying any other method is a waste of time.

Androgens are needed at normal levels. You want libido you need dopamine at minimum and histamine. EQ is mostly about nitric oxide thats why you can roid yourself up and get very high T levels and still have poor EQ, because androgens are not important unless they are too low.
 
Last edited:

rei

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Joined
Aug 6, 2017
Messages
1,276
Have you tried progesterone orally? Or large doses topically elsewhere than the balls? If you haven't then try before synthetic, potentially harmful AI (there has been much talk on the forum how the side effects from AI are not probably due to low estrogen, but the interactions AI:s cause with other things, like progesterone reduction). Progesterone is the endogenous anti-estrogen.
 

Hans

Member
Joined
Aug 24, 2017
Messages
3,213
After coming off gear a few years back I never fully recovered. I developed mild gynecomastia and a varicocele after PCT and then more or less lived through my early 20s with a limp ****.

During the Summer of 2019 I experimented with a trace mineral called Boron. To my surprise, within a few days my erection quality returned strong than ever before - for around about two weeks. After that it faded and Boron hasn't given me the same effect since (although it still does help).

I assumed this was a entirely down to Testosterone levels as my testicles grew by a very noticeable difference during the very short period of time I was on it.

In October I did a bloods. My T was 440ng/dl and E2 was on the lower end, so I decided to re-run PCT. My Testosterone levels peaked at around 1,450ng/dl yet I still seemed to have issues. My testicles were humongous. I mean, I couldn't even get anywhere close to closing my legs, yet the libido barely improved and EQ didn't shift at all. This baffled the hell out of me as all my other bloods were fine other than my higher-range prolactin levels and E2 (which was from the Clomid). The varicocele also become unbearably painful, although likewise I assumed it was just down the vein being choked harder. As my T and E2 dropped back down, so did the pain.

Since then I've been raising my T up naturally and am currently around 800ng/dl despite the varicocele. That being said, EQ still isn't the best and libido is unreliable. I have a very healthy lifestyle, although could never work out why Boron worked like magic the first time I used it. Cabergoline helped increase libido but not EQ, and Viagra didn't help with EQ either.

While asking a guy on Reddit for his take on varicoceles, he made the weirdest claim I had heard as of yet - Varicoceles are related to Estrogen. This confused me for a little bit so I asked him where he got his information from, and that's when he told me about Ray Peat.

I've been lurking here for the past two weeks sucking up all the information I can, and there seems to be two main theories to what cause varicoceles: the first being pelvic floor dysfunction (as PEGym also suggested) with the other being Estrogen.
I spent a lot of time working on pelvic floor tightness pre-lockdown and could almost do the front-splits although saw no progress with the varicocele or EQ.

Progeststerone cream directly on the veins & Vitamin E, as well as red-light therapy also saw no improvement. Actually, I've probably tried most things here, which is why I'm moving on to my next step: Letrozole.

Letrozole is an aromatese inhibitor that I formerly used to nuke old gynecomastia, although unfortunately it rebounded (which I believe to be because of my low T at the time).

This time I'm going to be very interested in the results. I know exercise will be hard on my joints for a good few weeks but it's worth the experiment.

Failing any success with Letrozole, I plan to move on to low-dose Proviron, which probably means I will have to run Nolvadex after to avoid any sort of HPTA shutdown. I'm pretty sure someone here posted that they managed to fix their varicocele within a few days of using Proviron.

So my question is: before I go and splash money of this drug, could Letrozole work in removing tissue estrogens from all over the body such as within varicoceles?

Cheers guys
Excess estrogen, nitric oxide and serotonin could cause the varicocele, but it doesn't mean that the varicocele remains there because those factors are still elevated. Meaning, you can still have a varicocele even if these factors returned to normal.
So taking an AI might not be the best approach, because E might already be back to normal for a while. The focus should be on restoring or improving the vasculature. A few things that can help is progesterone (both topical or oral should work, but since you already tried topical, perhaps you can try oral), gotu kola and making sure aldosterone and parathyroid hormone are low.
Charles Poliquin recommended gotu kola at doses of 2g daily for about 6 months for stretch marks and vein issues in general, so maybe that's something you can try out.
 

Sospian

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Messages
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If you want your **** to work optimally you need to focus on nitric oxide. Especially if your androgens are normal trying any other method is a waste of time.

Androgens are needed at normal levels. You want libido you need dopamine at minimum and histamine. EQ is mostly about nitric oxide thats why you can roid yourself up and get very high T levels and still have poor EQ, because androgens are not important unless they are too low.

I've tried working on nitric oxide. I supplement agmatine daily and PDE5 inhibitors don't do for me what Boron did the first time.
 

Sospian

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Thread starter
Joined
May 31, 2020
Messages
137
Location
United Kingdom
Have you tried progesterone orally? Or large doses topically elsewhere than the balls? If you haven't then try before synthetic, potentially harmful AI (there has been much talk on the forum how the side effects from AI are not probably due to low estrogen, but the interactions AI:s cause with other things, like progesterone reduction). Progesterone is the endogenous anti-estrogen.

Not orally but I've been using it topically daily with no avail
 

Sospian

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Thread starter
Joined
May 31, 2020
Messages
137
Location
United Kingdom
Excess estrogen, nitric oxide and serotonin could cause the varicocele, but it doesn't mean that the varicocele remains there because those factors are still elevated. Meaning, you can still have a varicocele even if these factors returned to normal.
So taking an AI might not be the best approach, because E might already be back to normal for a while. The focus should be on restoring or improving the vasculature. A few things that can help is progesterone (both topical or oral should work, but since you already tried topical, perhaps you can try oral), gotu kola and making sure aldosterone and parathyroid hormone are low.
Charles Poliquin recommended gotu kola at doses of 2g daily for about 6 months for stretch marks and vein issues in general, so maybe that's something you can try out.

I've tried both. Maybe not 2 whole grams of gotu kola but it didn't help.

Difference sources seem to tell me different things. Some say increase NO for the varicocele while others say to reduce it.
 

redsun

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Messages
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I've tried working on nitric oxide. I supplement agmatine daily and PDE5 inhibitors don't do for me what Boron did the first time.

Ok but this has nothing to do with promoting internal nitric oxide production, you are just using drugs in an attempt to artificially boost NO which doesnt always work and clearly in your case it did not.

Vitamin C (500mg-1g, or just get a lot from fruits), folic acid (3x800mcg daily), high arginine proteins, maintain adequate B2 intake (>2mg) and EQ should improve.
 

Sospian

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Ok but this has nothing to do with promoting internal nitric oxide production, you are just using drugs in an attempt to artificially boost NO which doesnt always work and clearly in your case it did not.

Vitamin C (500mg-1g, or just get a lot from fruits), folic acid (3x800mcg daily), high arginine proteins, maintain adequate B2 intake (>2mg) and EQ should improve.

I take 2g Vitamin C a day (1g in the morning and 1g before bed)

Vitamin B complex

For a while I was taking a lot of L-citrulline.

I've tried more or less everything and Boron was the only thing that fixed everything (temporarily)
 

redsun

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Messages
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I take 2g Vitamin C a day (1g in the morning and 1g before bed)

Vitamin B complex

For a while I was taking a lot of L-citrulline.

I've tried more or less everything and Boron was the only thing that fixed everything (temporarily)

Citrulline is not arginine. If your proteins contain a lot of arginine already than you shouldnt need to supplement extra arginine but if you are not thats a clear issue and that alone can be a problem. I would try just the higher dose folic acid for a week or two and see if EQ improves. A B-complex has a lot of vitamins and not all promote erectile function really.
 

Sospian

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How much Letrozole did you used?

2.5mg for 10 days, then 1.25mg for a week. Now currently on 0.625mg for another week as I taper off. I'm also using proviron; progesterone, and vitamin e to avoid any rebound. If I still get estro symptoms, I'll use some aspirin
 
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