kineticz
Member
lookingforanswers said:kineticz said:lookingforanswers said:kineticz said:Besides, this is where I disagree with Ray. It IS possible to overdo pregnenolone. He is anti-ACTH, but if you take too much pregnenolone, you will downregulate it, and feel depersonalised. I see forum members reporting this time and time again.
ACTH is a key stimulator of pregnenolone and therefore mood. Most pregnenolone mitochondria are in the adrenal cortex.
It is better to have high ACTH and low thyroid than low thyroid and low ACTH. He needs to warn people of this disclaimer.
Another theory is that pregnenolone is shown to stimulate a 5-Alpha reductase enzyme in the liver, and also a benzo type reaction. If this boosts internal pregnenolone, it will tell the adrenals that a stress response is not required, and still downregulate ACTH, leading to increased TRH and prolactin in it's attempt to invigorate adrenal enzymes and sustain energy production.
Okay can you elaborate on the purpose of bio lipid matrix versions of pregnenolone. Ray has said its a waste of money.is it superior to standard oral?
Where does Ray say this about lipid matrix?
Transdermal is the safest option to try pregnenolone.
Standard oral will immediately spike pregnenolone and activates some enzymes in the liver that may or may not be desirable. Pituitary is very sensitive to spiking.
Lipid matrix is very safe but very expensive and I needed high doses to feel good.
"Pregnenolone is a lipid, only pharmaceutical salesmen talk about the need for a lipid matrix. Most people don't have allergic reactions to the rice and magnesium stearate. "
Micronized I suppose it the important part missing. This micronized lipid matrix is said to bypass liver interference.