Progesterone Or Pregnenolone For Men?

Discussion in 'Hormones' started by harnessedinslums, Nov 5, 2013.

  1. harnessedinslums

    harnessedinslums Member

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    OK, so, my questions are probably elementary subject matter and they've probably already been answered but I couldn't find the right info no matter how much I searched.

    I am a man with bad estrogen dominance. My doctor prescribed me bio-identical testosterone cream but I've read that testosterone converts to estrogens easily in people with metabolic or nutritional problems. Does Peat recommend Progest-E or pregnenolone for men? I have liver problems too, possibly from toxic metals and fungal overgrowth, so I'm not sure if hormone treatment can help... I figure my liver might not be detoxing estrogen properly. Just looking for some basic help I guess.
     
  2. jyb

    jyb Member

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    You'd have to try for yourself - in theory pregnelonone firstly. If its like me and you're unlucky, then you'll discover within a day that its doesn't feel right, which could be due to either impurities in the supplement or to a metabolic problem. Then you could try some progesterone.
     
  3. j.

    j. Guest

    Many use both. Agree with jyb to try pregnenolone first.
     
  4. HDD

    HDD Member

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    Are you using aspirin?

    The following is from another thread by Peatarian. Peatarian has been studying and applying Ray Peat's philosophy for several years.

    "To lower your estrogen start by using aspirin. Make sure you use about 500mg after meals three times a day. Always dissolve the pills in warm water first and drink some Coca-Cola or Orange Juice with it."
     
  5. HDD

    HDD Member

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  6. HDD

    HDD Member

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    Too late to edit my post above.

    "Since the polyunsaturated fats and prostaglandins stimulate the expression of aromatase, the enzyme that synthesizes estrogen, aspirin decreases the production of estrogen. So many of aspirin's effects oppose those of estrogen, it would be tempting to suggest that its "basic action" is the suppression of estrogen. But I think it's more likely that both estrogen and aspirin are acting on some basic processes, in approximately opposite ways."

    http://raypeat.com/articles/aging/aspir ... ncer.shtml
     
  7. charlie

    charlie The Law & Order Admin

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  8. OP
    harnessedinslums

    harnessedinslums Member

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    Not taking it... I've read it can be hard on the digestive tract and the liver. Am I completely wrong?
     
  9. HDD

    HDD Member

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    "Although the animal studies that showed stomach damage from aspirin often used single doses equivalent to 10 or 100 aspirin tablets, the slight irritation produced by a normal dose of aspirin can be minimized by dissolving the aspirin in water. The stomach develops a tolerance for aspirin over a period of a few days, allowing the dose to be increased if necessary. And both aspirin and salicylic acid can be absorbed through the skin, so rheumatic problems have been treated by adding the drug to bath water."
    http://raypeat.com/articles/aging/aspir ... ncer.shtml
    (Bold mine)

    Peatarian's recommendation of dissolving and taking with orange juice or coke is for prevention of stomach and liver issues.
     
  10. HDD

    HDD Member

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    Vitamin e and carrot salad help in removing estrogen, too.
     
  11. HDD

    HDD Member

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    http://raypeat.com/articles/articles/vitamin-e.shtml


    "Other researchers, who knew that progesterone protected against the toxic effects of estrogen, described vitamin E as the "progesterone-sparing agent," since so many of its antiestrogenic effects resembled those of progesterone."
     
  12. OP
    harnessedinslums

    harnessedinslums Member

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    Thanks for the help. I'm taking a vitamin E complex and I do the daily carrot salad, which definitely seems helpful for digestion and motility, but I haven't notice an effect on estrogen dominance symptoms.
     
  13. johns74

    johns74 Member

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    Lita Lee, in her fruit of cholesterol article, says that it's not good for young males because it suppresses libido.

    I guess one possibility of how progesterone could be bad for males is reduction of DHT, if DHT happens to have effects other than libido, which are vital.
     
  14. johns74

    johns74 Member

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    One thing that gives me pause about progesterone for males is that it has similar effects to finasteride, the hair loss drug. One similar effect is inhibition of DHT. Finasteride can result in permanent erectile dysfunction. While this effect probably can't happen with progesterone, can supraphysiological progesterone in males and finasteride have some overlapping toxic effects?
     
  15. Such_Saturation

    Such_Saturation Member

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    Zinc and B6 inhibit 5α-reductase, so there you go. Don't eat zinc or vitamins.
     
  16. johns74

    johns74 Member

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    I'm just saying it should be researched. I'm not yet as wise as you to rule out bad effects.

    I read that finasteride and progesterone are similar chemically. I wouldn't think zinc is similar chemically to finasteride.
     
  17. Such_Saturation

    Such_Saturation Member

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    Well, there are few experiments within our grasp which are better than taking it ourselves, and many males take a low or high dose with regularity. I never took more than a few drops but the problem if any is rather the opposite than the one you fear.
     
  18. johns74

    johns74 Member

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    Could it feminize your brain after taking high doses for prolonged times?
     
  19. Such_Saturation

    Such_Saturation Member

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    No idea! Of course there is little difference between "brains" when they are healthy. The stereotypes always refer to underlying conditions.
     
  20. smith

    smith Member

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    Good question. Still wondering about this
     
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