Progesterone In Men

[baccheion]

Should probably use pregnenolone (+ DHEA), adding progesterone only if still not in the preferred range.

 

[Progesterone]

Mens should not use more than 10Mg of Progesterone daily. And the best thing is to combine Progest. With Some Low Dose Dhea .

What happens if men use more than 10mg progesterone daily?

 

[Gabriel Dell]

What happens if men use more than 10mg progesterone daily?

I think it could Decrease too much Libido - Erection

 

[ecstatichamster]

Some people will do fine with 20mg or even 50mg a day for awhile. It can be very important and helpful.

200mg or more is what is needed to shrink the penis and cause chemical “castration”.

 

[Sheik]

Some people will do fine with 20mg or even 50mg a day for awhile. It can be very important and helpful.

200mg or more is what is needed to shrink the penis and cause chemical “castration”.

Is this oral or transdermal?

 

[Gabriel Dell]

Some people will do fine with 20mg or even 50mg a day for awhile. It can be very important and helpful.

200mg or more is what is needed to shrink the penis and cause chemical “castration”.

If you take More than 200Mg. Will It shrink your penis forever ? Or will It get back to normal when you Stop ?

 

[Progesterone]

I've never heard or experienced that...

 

[ecstatichamster]

Dr. Peat has said that. It is dose dependent. I think some men may do okay with large amounts for awhile, if they have high estrogen.

See:

Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys - ScienceDirect
Synthetic progestins such as medroxyprogesterone acetate (MPA) are used widely in the treatment of male sex offenders. In male cynomolgus monkeys (Macaca fascicularis) treated with testosterone (T), both MPA and progesterone (P) had comparable inhibitory effects on male sexual motivation and behavior. To determine if P, like MPA, decreases endogenous T levels, plasma T and P levels were analyzed in weekly blood samples (N=186) from eight intact males, each paired with a sexually receptive female before, during, and after treatment with subcutaneous Silastic P implants (336 behavior tests). P treatment decreased sexual activity but not plasma T levels. To ascertain if P, like MPA, acts by decreasing the nuclear uptake of T by brain, four P-treated and four control males were euthanized 60 min after intravenous injection of 3 mCi of [3H]T. The nuclear uptake of unchanged [3H]T and its metabolites [3H]E2 and [3H]DHT was measured in samples of brain, pituitary gland, genital tract, and liver. P, unlike MPA, did not affect the nuclear uptake of [3H]androgens by brain, but reduced by 80% the nuclear accumulation of [3H]E2 in tissue samples containing preoptic area and the anterior part of the bed nucleus of stria terminalis, although not in samples from hypothalamus or amygdala.

 

[xetawaves]

I’ve experienced decreased libido from progesterone but DHEA counters it for me.

 

[Progesterone]

Dr. Peat has said that. It is dose dependent. I think some men may do okay with large amounts for awhile, if they have high estrogen.

See:

Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys - ScienceDirect
Synthetic progestins such as medroxyprogesterone acetate (MPA) are used widely in the treatment of male sex offenders. In male cynomolgus monkeys (Macaca fascicularis) treated with testosterone (T), both MPA and progesterone (P) had comparable inhibitory effects on male sexual motivation and behavior. To determine if P, like MPA, decreases endogenous T levels, plasma T and P levels were analyzed in weekly blood samples (N=186) from eight intact males, each paired with a sexually receptive female before, during, and after treatment with subcutaneous Silastic P implants (336 behavior tests). P treatment decreased sexual activity but not plasma T levels. To ascertain if P, like MPA, acts by decreasing the nuclear uptake of T by brain, four P-treated and four control males were euthanized 60 min after intravenous injection of 3 mCi of [3H]T. The nuclear uptake of unchanged [3H]T and its metabolites [3H]E2 and [3H]DHT was measured in samples of brain, pituitary gland, genital tract, and liver. P, unlike MPA, did not affect the nuclear uptake of [3H]androgens by brain, but reduced by 80% the nuclear accumulation of [3H]E2 in tissue samples containing preoptic area and the anterior part of the bed nucleus of stria terminalis, although not in samples from hypothalamus or amygdala.

Welp...

I am using estrogen currently as well, so...

bi-estro cream. 1mg estriol, 0.25mg estradiol, per pump.

acne = gone. face smoothing out like crazy, looks terrific.
erections = harder, occur more often.

also using around 70-80mg of progesterone a day.

mimicking women's pregnancy (high levels of prog/estriol) for hair.

new little hairs are popping up around hairline too.

so sides so far, only benefits, which doesn't make sense.

 

[baccheion]

Welp...

I am using estrogen currently as well, so...

bi-estro cream. 1mg estriol, 0.25mg estradiol, per pump.

acne = gone. face smoothing out like crazy, looks terrific.
erections = harder, occur more often.

also using around 70-80mg of progesterone a day.

mimicking women's pregnancy (high levels of prog/estriol) for hair.

new little hairs are popping up around hairline too.

so sides so far, only benefits, which doesn't make sense.

So, you're lowering DHT?

 

[Progesterone]

So, you're lowering DHT?

I guess, technically I am?

Not sure MOA of why it's making me feel so good and have all these benefits.

Estrogens in Male Physiology. - PubMed - NCBI

Estrogens have historically been associated with female reproduction, but work over the last two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) and G protein-coupled estrogen receptor (GPER) also regulate male reproductive and nonreproductive organs. 17β-Estradiol (E2) is measureable in blood of men and males of other species, but in rete testis fluids, E2 reaches concentrations normally found only in females and in some species nanomolar concentrations of estrone sulfate are found in semen. Aromatase, which converts androgens to estrogens, is expressed in Leydig cells, seminiferous epithelium, and other male organs.
Recent evidence also indicates that membrane ESR1 has critical roles in male reproduction. Thus estrogens are important physiological regulators in males, and future studies may reveal additional roles for estrogen signaling in various target tissues.

 

[Beefcake]

I guess, technically I am?

Not sure MOA of why it's making me feel so good and have all these benefits.

Estrogens in Male Physiology. - PubMed - NCBI

Estrogens have historically been associated with female reproduction, but work over the last two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) and G protein-coupled estrogen receptor (GPER) also regulate male reproductive and nonreproductive organs. 17β-Estradiol (E2) is measureable in blood of men and males of other species, but in rete testis fluids, E2 reaches concentrations normally found only in females and in some species nanomolar concentrations of estrone sulfate are found in semen. Aromatase, which converts androgens to estrogens, is expressed in Leydig cells, seminiferous epithelium, and other male organs.
Recent evidence also indicates that membrane ESR1 has critical roles in male reproduction. Thus estrogens are important physiological regulators in males, and future studies may reveal additional roles for estrogen signaling in various target tissues.

Aromatise inhibitors never made me feel any good. Only side effects. They are only usefull if you actually have high estrogen in the first place or use steroids that increase E and you need to keep it down. If my E goes under 20 i feel like crap.

 

[Progesterone]

This is fascinating.

Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. - PubMed - NCBI

CONCLUSIONS:
Contrary to the postulated racial difference, testosterone concentrations did not differ notably between black and white men. However, blacks had higher estradiol levels. Mexican-Americans had higher testosterone than whites but similar estradiol and SHBG concentrations. Given these findings, it may be equally if not more important to investigate estradiol as testosterone in relation to diseases with racial disparity.

 

[Progesterone]

Aromatise inhibitors never made me feel any good. Only side effects. They are only usefull if you actually have high estrogen in the first place or use steroids that increase E and you need to keep it down. If my E goes under 20 i feel like crap.

Thanks for the reply.

So you're saying, you're not surprised I am having nothing but positive effects on estrogen?

 

[Progesterone]

Wow.

Estrogens--male hormones? - PubMed - NCBI

Together with the widespread distribution of estrogen receptors (ERalpha and ERbeta) in the genital tract of the male, a physiological role for estrogens in the regulation of mammalian reproductive functions including the regulation of gonadotropin feedback, is now well recognized. Moreover, in men the aromatase deficiency is associated with severe bone maturation problems, alterations of lipid and sugar metabolism and sterility; but conversely an excess of estrogens is responsible for the impairment of spermatogenesis. In addition, estrogens play an important role in the control of osteoporosis and of atherosclerosis, especially in elderly men. Consequently, estradiol seems to be a critical factor not only for normal reproduction (at least for maturation and survival of germ cells) but also for various physiological processes and thus, estrogens should be now considered as "male hormones".

 

[Beefcake]

Wow.

Estrogens--male hormones? - PubMed - NCBI

Together with the widespread distribution of estrogen receptors (ERalpha and ERbeta) in the genital tract of the male, a physiological role for estrogens in the regulation of mammalian reproductive functions including the regulation of gonadotropin feedback, is now well recognized. Moreover, in men the aromatase deficiency is associated with severe bone maturation problems, alterations of lipid and sugar metabolism and sterility; but conversely an excess of estrogens is responsible for the impairment of spermatogenesis. In addition, estrogens play an important role in the control of osteoporosis and of atherosclerosis, especially in elderly men. Consequently, estradiol seems to be a critical factor not only for normal reproduction (at least for maturation and survival of germ cells) but also for various physiological processes and thus, estrogens should be now considered as "male hormones".

Thanks for the reply.

So you're saying, you're not surprised I am having nothing but positive effects on estrogen?

Yeah im a firm believer that you should have neutral estrogen levels. If your slim muscular male with low end body fat I dont think you need to think about your endogenous estrogen or try to lower it to achieve some super hormonal status. You should take percautions to avoid xeno estrogens. Aromazin which basically binds to the aromatase enzyme and kills it so it depletes all your aromatase. Is an extremly effective anti estrogen. But even from the lowest of lowest doses it gives me side effects. I just dont tolerate it and I have always felt my best when my own E tends to be mid-higher range. Low-mid is ok but I dont feel as happy, libido is not as good. Low-very low is the worst feeling. Splitting headache 24/7, zero libido. Like you could bring in 10 pornstars inject me with viagra and say if I **** em I get a bilion dollars and I would not even get close to a semi boner. With zero estrogen I get zero libido. Its
Impossible. Only thing I do notice that is positive is tighter and firmer muscles. But could also just be getting rid of water retention. Long term estrogen deficiency likely causes skin aging, drying and stiff/leathery skin.

 

[Beefcake]

Wow.

Estrogens--male hormones? - PubMed - NCBI

Together with the widespread distribution of estrogen receptors (ERalpha and ERbeta) in the genital tract of the male, a physiological role for estrogens in the regulation of mammalian reproductive functions including the regulation of gonadotropin feedback, is now well recognized. Moreover, in men the aromatase deficiency is associated with severe bone maturation problems, alterations of lipid and sugar metabolism and sterility; but conversely an excess of estrogens is responsible for the impairment of spermatogenesis. In addition, estrogens play an important role in the control of osteoporosis and of atherosclerosis, especially in elderly men. Consequently, estradiol seems to be a critical factor not only for normal reproduction (at least for maturation and survival of germ cells) but also for various physiological processes and thus, estrogens should be now considered as "male hormones".

I did at one point over supplement with zinc and that made me like estrogen deficient 24/7. Later I realized I depleted copper snd copper and estrogen synergises.

 

[lampofred]

Welp...

I am using estrogen currently as well, so...

bi-estro cream. 1mg estriol, 0.25mg estradiol, per pump.

acne = gone. face smoothing out like crazy, looks terrific.
erections = harder, occur more often.

also using around 70-80mg of progesterone a day.

mimicking women's pregnancy (high levels of prog/estriol) for hair.

new little hairs are popping up around hairline too.

so sides so far, only benefits, which doesn't make sense.

Come on man... How can you have that as your username and be taking estrogen at the same time.

I completely understand why you're doing it, I was pretty frantic as well about finding any cure possible back when I was experiencing hair loss, but when someone as intelligent as Dr. Peat is so strongly against it, I would be extremely careful and vigilant to make sure you don't create any long-term consequences for yourself...

I think even chewing tobacco would be a lot safer (if things like aspirin and high dose caffeine aren't strong enough to protect hair) and that would be really pro-hair.

 

[lampofred]

Wow.

Estrogens--male hormones? - PubMed - NCBI

Together with the widespread distribution of estrogen receptors (ERalpha and ERbeta) in the genital tract of the male, a physiological role for estrogens in the regulation of mammalian reproductive functions including the regulation of gonadotropin feedback, is now well recognized. Moreover, in men the aromatase deficiency is associated with severe bone maturation problems, alterations of lipid and sugar metabolism and sterility; but conversely an excess of estrogens is responsible for the impairment of spermatogenesis. In addition, estrogens play an important role in the control of osteoporosis and of atherosclerosis, especially in elderly men. Consequently, estradiol seems to be a critical factor not only for normal reproduction (at least for maturation and survival of germ cells) but also for various physiological processes and thus, estrogens should be now considered as "male hormones".

Yes estrogen is what causes "brain masculinization" and things like hairiness, not testosterone. But the "masculinity" that it induces is what is called toxic masculinity. Testosterone without estrogen is the hormone of good strength. Progesterone is the hormone of brains.