At that dosage its hard to believe it would cause bad side effects if its good quality preg. It could be lowering blood sugar though
I found these in the email advice depo:
Ray Peat Email Advice Depository
Regarding Possible Pregnenolone Side Effects
flaviom said:
FWIW I mailed Ray about the issues I was having with pregnenolone, namely sadness, irritability, major hair loss, insomnia, weight gain and here's his reply:
Ray Peat said:
Excipients or impurities in capsules can cause symptoms, by irritating the intestine. In animal studies (and in myself), extremely large doses didn't have any more effects than minimal doses. It's possible to eliminate some of the impurities by mixing it with warm vitamin E, and after stirring it, allowing it to settle, and using only what dissolved in the vitamin E.
flaviom said:
Then I asked if there's no way it can convert to excess estrogen or some other stress related hormone, under certain circumstances, like not getting enough protein or sugar, or some other nutrient, or adequate light. Also asked if someone is running on stress hormones from low thyroid and pregnenolone lowers those hormones, would it make things worse by lowering the metabolism even further.
Ray Peat said:
I haven't heard of a situation like that; I'll see if I can find any information relating to that possibility.
Also it seems a fair amount of people have been emailing him with reports of problems with pregnenolone and there's concern about the purity of whats available on the market. You might get something out of this podcast as well, I've been paying a lot more attention to how stuff effects me lately and pretty much the only thing I take orally anymore is progest-e and desiccated thyroid