Understood.
My intention is to use a GR antagonist to inhibit Bile acid reabsorption via ASBT/slc10a2.
Could 6-progesterone accomplish that?
If no, what substance may be a better bet?
Question:
Does 6-ketoprogesterone retain normal form Progesterone's cyp-inducing effects as a PXR agonist?
Not much is known about these possible effects. There have been very few studies on 6-keto and so far the only indication is that it has anticatabolic effect on muscles. Any other effects are speculative at this point.