6-keto P4 - Liquid 6-ketoprogesterone For Lab/R&D

[haidut]

Some initial feedback.

Noticed some increased muscle hardness and less water retention.

However I've also had some joint/muscle pain in my hands and feet as well as tooth pain. What concerns me is that this is lowering cortisol too much. I have experienced similar things in the past and it resulted in very bad foot and knee pain.

I started with only 3mg before bed then moved it up to 5 then 10. I think I might only use this on occasion as I am weary of lowering cortisol too much due to the discomfort and other risks.

Thanks for the feedback. I did not notice joint pain from any dose. Do you get similar effects from progesterone?

 

[Soren]

Thanks for the feedback. I did not notice joint pain from any dose. Do you get similar effects from progesterone?

I've never taken regular progesterone before. I've had a similar effects from pansterone, androsterone, and too much vitamin A.

I definitely feel a lot less stressed on this and much better at tolerating stress.

Just took 5mg now before going to bed and the joint pain comes on quite quickly probably in about 10 minutes.

 

[Soren]

Further update.
After using it for a few weeks I can say that this is one of the strongest anti-stress supplements I have ever taken!

Muscle strength and gain is through the roof from very little exercise.

After a very stressful day taking 10mg before bed and the next day I really notice the effects.

For me if I use it daily I think the effect is too powerful and I get joint pain. I would recommend people start with a small dose ( 1-2mg) and build up and experiment to see what is right for you.

All and all amazing supplement.

 

[Mufasa]

Too early to say, but some people who use it on its own said their hair is getting thicker. One is a guy in his 30s and one is a woman in her 60s.

Is this with topical application on the hairline?

 

[haidut]

Is this with topical application on the hairline?

The guy was doing topical on the scalp and the woman orally (the tocopherol version).

 

[dand]

So far I can see minor strength increases. Less dry skin on heel too.

I notice dry skin and somewhat thick calluses on my feet at times. What is that supposed to indicate so I can watch for improvement? Thank you!

 

[ddjd]

I have always had very peculiar progesterone response, similar to the guy in the Peat story that used progesterone for snapping out of addiction. I have taken several hundred mg a day without feeling strong sedation.

I think this could be related to GABA. I find increasing GABA through various mechanisms like progesterone completely stops my addictive urges; gambling, porn, raypeatforum

 

[keith]

This one seems to affect me very strangely. The first day I got it, I took 5 drops orally when the mail came, and it did seem to reduce stress significantly. I took another 5 before bed, and seemed to sleep a little better than normal.

I noticed the next day that I felt off, in a negative way, but that I can’t clearly define. I dropped the dose to 2 drops, but took it 3 times per day (6 drops total), because the stress relief was obvious when I took it, even at a lower dose. However, over the course of the week, I noticed I was getting anxiety, which has not been an issue for me since I started eating “peaty”. My blood pressure also increased by about 10% while my pulse decreased by about 10%. I tried different (smaller) doses and taking it just at night over the week, topically (seemed worse) and orally, before determining this isn’t the right thing for me, at least not given my present state.

The anxiety went away quickly when I discontinued use. The blood pressure and pulse have not normalized yet, although it has only been about a day. I’m not 100% sure it was the 6-Keto P4, but that’s the only thing I was doing different.

I am a big fan of idealabs, and also of self-experimentation so am not trying to bad mouth the product. I just wanted to share my experience to help others decide if this is something they want to try. It seems my experience may be unique, since I don’t recall seeing that anyone else had a similar experience.

I’m guessing that I may be experiencing a rebound effect when it wears off. If it is just blocking the effect of cortisol, but not actually reducing it, perhaps I am accumulating it, or my body is producing more to compensate.

I may experiment again later, at much lower doses, and if I do, I will provide an update. Hope this helps someone. Happy experimenting. Be safe.

 

[TripleOG]

I tried different (smaller) doses and taking it just at night over the week, topically (seemed worse) and orally, before determining this isn’t the right thing for me, at least not given my present state.

Do you mean your negative symptoms became worse with topical application (therefore, stronger effects), or that topical application wasn't as effective as oral for you? SFA/ethanol or Tocopherol/MCT version?


As for your overall experience, hows your thyroid health?

 

[keith]

Do you mean your negative symptoms became worse with topical application (therefore, stronger effects), or that topical application wasn't as effective as oral for you? SFA/ethanol or Tocopherol/MCT version?


As for your overall experience, hows your thyroid health?

Symptoms seemed worse with topical application. I used the sfa/ethanol version. It may just have been the timing, though, since I tried after having issues with oral administration. I have no recent blood work to objectively answer on thyroid health.

 

[keith]

For whatever it is worth to anyone reading this, my blood pressure and pulse seem to have normalized (for me) after 2 days discontinuance. BP is a little higher and pulse a little lower than average, but back within the range that I normally see.

 

[haidut]

This one seems to affect me very strangely. The first day I got it, I took 5 drops orally when the mail came, and it did seem to reduce stress significantly. I took another 5 before bed, and seemed to sleep a little better than normal.

I noticed the next day that I felt off, in a negative way, but that I can’t clearly define. I dropped the dose to 2 drops, but took it 3 times per day (6 drops total), because the stress relief was obvious when I took it, even at a lower dose. However, over the course of the week, I noticed I was getting anxiety, which has not been an issue for me since I started eating “peaty”. My blood pressure also increased by about 10% while my pulse decreased by about 10%. I tried different (smaller) doses and taking it just at night over the week, topically (seemed worse) and orally, before determining this isn’t the right thing for me, at least not given my present state.

The anxiety went away quickly when I discontinued use. The blood pressure and pulse have not normalized yet, although it has only been about a day. I’m not 100% sure it was the 6-Keto P4, but that’s the only thing I was doing different.

I am a big fan of idealabs, and also of self-experimentation so am not trying to bad mouth the product. I just wanted to share my experience to help others decide if this is something they want to try. It seems my experience may be unique, since I don’t recall seeing that anyone else had a similar experience.

I’m guessing that I may be experiencing a rebound effect when it wears off. If it is just blocking the effect of cortisol, but not actually reducing it, perhaps I am accumulating it, or my body is producing more to compensate.

I may experiment again later, at much lower doses, and if I do, I will provide an update. Hope this helps someone. Happy experimenting. Be safe.

Thanks for the honest feedback.
I personally found the best effects when used with Pansterone. I think 6-keto, being a progestogen, may compete with progesterone and T for access to the 5-AR enzyme and when used on its own to result in lower DHT or allopregnanolone levels. I did not experience what you describe when used on its own but combining with Pansterone definitely felt better than used on its own.

 

[Satellite]

Hello,

I deleted the original comment, and put this instead.
I don't know how to delete this comment.

I thought I posted it in the Idealabs Comments and Suggestions thread.

I reposted it there.

Sorry for any inconvenience.

 

[Trev]

This is the only bodybuilding supplement I found on the market that contains 6-keto P4.
One serving contains 50mg 6-Keto-Pregn-4-ene-3,20-dione and they recommend 2 servings per day.

@haidut what's your thoughts on this product as a effective muscle builder and its safety?

 

[Epistrophy]

This is the only bodybuilding supplement I found on the market that contains 6-keto P4.
One serving contains 50mg 6-Keto-Pregn-4-ene-3,20-dione and they recommend 2 servings per day.

@haidut what's your thoughts on this product as a effective muscle builder and its safety?



View attachment 11172 View attachment 11173

There one called 6-Mass with way less ingredients than the one you mentioned. But not sure why you would want these brands when you can just use the pure form from haidut.

 

[Trev]

The Mega Mass product recommends 2 x 50mg doses daily.
Thats a large dose of 6-Keto-Pregn-4-ene-3,20-dione per day for 30 days as the label says.
Maybe I'm wrong but I don't think you could get that amount of 6-keto from Haiduts product.
I know the other product has extra crap in it.
I want is some thoughts on ingesting 200mg per day of 6-keto.
Pros and cons ya know.
Remember I'm looking at 6-keto for it's muscle building potentials.
I'm willing to try it and report back.

 

[Epistrophy]

The Mega Mass product recommends 2 x 50mg doses daily.
Thats a large dose of 6-Keto-Pregn-4-ene-3,20-dione per day for 30 days as the label says.
Maybe I'm wrong but I don't think you could get that amount of 6-keto from Haiduts product.
I know the other product has extra crap in it.
I want is some thoughts on ingesting 200mg per day of 6-keto.
Pros and cons ya know.
Remember I'm looking at 6-keto for it's muscle building potentials.
I'm willing to try it and report back.

Haidut response to me about an upper limit of six keto was about 40 mg per day. So I think 200 mg may not be needed.

 

[Chung_pao]

Hello,

I was researching the web looking for a potent Antiglucocorticoid / GR antagonist, and came upon the research on Ketoprogesterone.

This lead me to this forum and your thread on 6-ketoprogesterone.

My question is:
I was actually looking for 11-ketoprogesterone but considered "settling" for and testing 6-ketoprogesterone (awaiting shipment).

Why didn't you just create 11-ketoprogesterone as an Antiglucocorticoid instead?

It has scientific proof of being a potent inhibitor of the primary Cortisol synthesizing enzyme:
11β-hydroxysteroid dehydrogenase.

11-Ketoprogesterone - Wikipedia


Wouldn't that be a more effective way to counteract cortisol?

 

[haidut]

Hello,

I was researching the web looking for a potent Antiglucocorticoid / GR antagonist, and came upon the research on Ketoprogesterone.

This lead me to this forum and your thread on 6-ketoprogesterone.

My question is:
I was actually looking for 11-ketoprogesterone but considered "settling" for and testing 6-ketoprogesterone (awaiting shipment).

Why didn't you just create 11-ketoprogesterone as an Antiglucocorticoid instead?

It has scientific proof of being a potent inhibitor of the primary Cortisol synthesizing enzyme:
11β-hydroxysteroid dehydrogenase.

11-Ketoprogesterone - Wikipedia


Wouldn't that be a more effective way to counteract cortisol?

The 11-keto progesterone actually inhibits 11b-HSD2 much more potently than 11b-HSD1, so over time it actually ends up increasing cortisol levels. This is well known and has been tested in animals. It is one of the reasons 11-keto progesterone was not approved for use as a veterinary drug.
Read the Wikipedia page you linked to carefully, it is all explained there. The steroid raises blood glucose levels and acts like the glucocorticoid hormone cortisone. Definitely not something somebody I am interested in.

 

[Chung_pao]

The 11-keto progesterone actually inhibits 11b-HSD2 much more potently than 11b-HSD1, so over time it actually ends up increasing cortisol levels. This is well known and has been tested in animals. It is one of the reasons 11-keto progesterone was not approved for use as a veterinary drug.
Read the Wikipedia page you linked to carefully, it is all explained there. The steroid raises blood glucose levels and acts like the glucocorticoid hormone cortisone. Definitely not something somebody I am interested in.

Understood.

My intention is to use a GR antagonist to inhibit Bile acid reabsorption via ASBT/slc10a2.
Could 6-progesterone accomplish that?
If no, what substance may be a better bet?

Question:
Does 6-ketoprogesterone retain normal form Progesterone's cyp-inducing effects as a PXR agonist?