glucocorticoid

  1. haidut

    Glucocorticoids may increase inflammation in the long run

    Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments - i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as...
  2. haidut

    Cortisol may drive COVID-19 mortality

    The reason I decided to do a post on this study is that over the last several months, various public health authority bodies around the world have adopted "treatment protocols" for COVID-19 hospitalized patients, and virtually all such protocols contain a potent synthetic glucocorticoid such as...
  3. haidut

    Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

    A really interesting study, which will likely generate more than a few hateful emails for my Inbox :): Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER)...
  4. haidut

    Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

    In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a...
  5. haidut

    Cheating Is Driven By Cortisol, Not Testosterone

    The topic of macho behavior and its apparent mediator testosterone has been studies every since steroids were discovered. The mainstream dogma states that high testosterone drives cheating behavior (especially of males) as some sort of dominance-asserting behavior of genetically superior...
  6. haidut

    Cortisol (stress) Directly Causes Depression

    I have posted quite a few threads/posts on the role of stress as perhaps the main cause of depression and other mental disorders. Officially, psychiatry claims that no environmental factor is known to be a direct cause of depression and that depression is a “complex” mix of genetic...
  7. haidut

    Cortisol Therapy Makes Cancer Resistant To Treatment

    As many forum users probably know, glucocorticoid treatment is one of the main lines of therapies in cancer. It is considered highly beneficial due to reducing inflammation and swelling/pain in inflamed/cancerous tissue. However, recent studies have shown that immune dysfunction is perhaps the...
  8. haidut

    PUFA Enhance Glucocorticoid (cortisol) Signalling

    I posted some studied in the past on the estrogenic and pro-cortisol effects of PUFA, as well as the pro-androgen effects of SFA. One of those studies showed that PUFA increases cortisol synthesis even in the absence of ACTH, which suggests that they may have pituitary hormonal-like effects...
  9. haidut

    6-keto P4 - Liquid 6-ketoprogesterone For Lab/R&D

    As many forum users know, preventing tissue destruction as a result of hypothyroidism and stress is one of the main topics the pro-metabolic approach focuses on. While tissue catabolism can be drive by a number of mediators working in tandem, the main catabolic steriod in the human organism is...
  10. haidut

    Biomarkers Of Muscle And Liver Insulin Resistance

    I am posting this study mostly as a heads-up for @Dan Wich and his website for lab test comparison. I know quite a few people here struggle with insulin resistance but the doctors do not know how to test for it beyond the simple fasting blood glucose (which is unreliable and easily skewed by...
  11. haidut

    Successful Antidepressant Drugs Are Glucocorticoid Antagonists

    Peat was asked a few times about his opinion on SSRI drugs and he said that 1) he does not recommend them because they are systemically serotonergic, and 2) their mechanism of action is really not what big pharma would have us believe. Since then, SSRI drugs that have been shown to actually work...
  12. haidut

    Exercise + Fasting Is Stress, Causes Obesity And IR, And Requires Cortisol Blockade To Reverse

    I think this thread will ring true for all people who at some in their lives exercised in order to lose weight. Just like fasting, it works great in younger age (<30) but it really masks a bigger metabolic problem and of course badly backfired in the long run. Exercise is a forced/stressed...
  13. haidut

    Structural Requirements For An Optimal Anti-Catabolic Steroid

    This post will be a bit long, but I hope it is worth it. I think @Jsaute21 and @dand will find it highly interesting but the information here applies just as much to females wishing to preserve lean tissue and prevent the catabolism that often occurs with aging. Here we go. Lately, I have been...
  14. haidut

    Cortisol And Serotonin Are Causative Agents In (male) Liver Cancer

    The role of serotonin in all cancers of the billiary and GI tracts was well-known in the first half of the 20th century. The term carcinoid syndrome was used to describe the spectrum of such cancers and it was widely acknowledged that most of the patients died as a result of the fibrosis that...
  15. haidut

    Vitamin D Restores Sensitivity To Cortisol

    The so-called "glucocorticoid resistance" is thought be behind a number of degenerative conditions including diabetes, depression, schizophrenia, chronic inflammation, autoimmune conditions, etc. The condition, similar to insulin resistance, is characterized by elevated serum cortisol levels and...
  16. haidut

    The Anti-cortisol Mechanism Of Progesterone

    I just posted the thread on the anti-cortisol mechanism of pregnenolone. The Anti-cortisol Mechanism Of Pregnenolone As I mentioned in that thread, the Peat has been saying that both pregnenolone and progsterone have anti-cortisol effects, however people have been questioning those statements...
  17. haidut

    The Anti-cortisol Mechanism Of Pregnenolone

    One of the recurring arguments on this forum is whether pregnenolone and progesterone (being technically precursor to the glucocorticoids) raise or lower cortisol levels, and whether they have effects opposing or promoting those of the glucocorticoids. The argument advanced by a few people here...
  18. haidut

    Stress Leads To Lower Dopamine And More Drinking

    The study was really on alcohol consumption what affects it. It has been known since the 1960s that people drink more when under stress but to this day mainstream medicine denies that there is a causative link between stress and substance abuse. I posted a few studies showing that "addicts" have...
  19. haidut

    DHT Reduces Glucocorticoid Effects

    I mentioned this on one of the Danny Roddy shows, but wanted to post this study here as many people have been asking me for references over email. In addition to reducing glucocorticoid effects, DHT is also an estrogen "receptor" antagonist as I posted in another thread. DHT Is Estrogen...
  20. J

    Glucocorticoids Cause Brain Damage

    For the last few years, studies on the use of glucocorticoids ( prednisone, dexamethasone,ect) resulted in a smaller hippocampus and prefrontal cortex. Causing memory loss, attention loss and lower concentration. This study shows that Prednisone can actually reduce brain weight and decrease...
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