DaveFoster
Member
Interesting; progesterone often relieves anxiety but rarely induces euphoria. Caffeine is a stronger euphoric effect, but it's often anxiogenic. Ondansteron is an antagonist of 5-HT3, so I'm deriving that euphoria is derived from 5-HT2C and antidepressive effects from the 5-HT3 receptors respectively.Most successful SSRI drugs are actually antagonists on 5-HT2C and also boost allopregnanolone levels. Either one of these can produce the euphoria. Also, some of the SSRI drugs can raise cortisol due to the overall effect of SSRI being pro-serotonergic despite the 5-HT2C antagonism, and high cortisol can also produce euphoria initially.
In my experience 5a-DHP is best used on its own. The effects of progesterone on the nervous system have been shown to depend on 5-AR activity so we know the benefits are due to either 5a-DHP or other steroids derived from it.