Ray Peat Email Advice Depository

Discussion in 'Email Advice' started by charlie, Jan 14, 2013.

  1. charlie

    charlie The Law & Order Admin

    Jan 4, 2012
    This thread will be for posting email exchanges from Ray Peat.

    This thread is reserved for email advice exchanges only. If you would like to discuss anything posted in this thread, feel free to make your own thread, or you can go over the Ray Peat Email Advice Depository Discussion/Comment Thread

    Please help by posting email exchanges you have had, or any exchange that you run across on the web. Please give citation or hat tip when possible.

  2. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Light Therapy

    When asked about light therapy:

  3. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Restoring Color to Gray Hair

  4. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    :hattip Kasra over at Peatarian.

    (Similar question by shaadoe)

  5. bradley

    bradley Member

    Aug 16, 2012
    Re: Ray Peat Email Advice: Migraine

    On aborting a migraine:

  6. cliff

    cliff Member

    Jul 26, 2012
    Los Angeles
    Q: Do you think alkalized cocoa has any benefits over normal cocoa?
    A:The idea is to remove the fat so that it mixes easily with milk.

    Q:Someone told me you drink HFCS coke regularly? do you think it is not
    that harmful if someone is healthy?
    A:I prefer Mexican coke with real sugar (it tastes very different), but metabolically there isn't much difference.

    Q: Does a protein deficiency lower liver detoxification due to increased
    muscle breakdown which inhibits thyroid via amino acids which lowers
    metabolic efficiency of liver?
    A:Yes, I think that's at least part of how it works.

    Q: Do you think any of the dessicated thyroid products are good?
    A:I haven't seen anything that compares well with the original Armour.

    Q: Do you think zinc oxide is the least harmful commercially available sunscreen?

    Q:In mitochondria and mortality you mention pyruvate having similar effects of lactate. Isn't pyruvate necessary for oxidative metabolism? Is pyruvate only bad when mitochrondia can't fully metabolize it?

    Q: Do you think pure USP B vitamins, like niacinamide or b1, are safe?
    A:Because of individual sensitivities, each one should be tested carefully. Allergic reactions sometimes show up within a few minutes of contacting your mouth, other times it takes a couple of days to see a bad reaction. The worst one is B2, folic acid is next for allergies. B1, pantothenic acid, niacinamide and B6 are pretty safe.

    Q: Does T3 act like caffeine in the way if you don't eat enough sugar you can get nervousness, heart skipping, headaches, etc?
    A:Not like caffeine, but if too much is taken suddenly, a person who has been deficient in thyroid is likely to experience an excess of adrenaline. Since the body normally produces about 4 mcg of T3 in an hour, taking 10 or 20 mcg at once is unphysiological.

    Q:Is it ok to eat baking soda with protein meals or does it buffer stomach acid?
    A:It slows digestion down for a few minutes.

    Q:When you say several effects of co2 shuts off glycolysis, do you mean anaerobic glycolysis or all glycolysis, if all glycolysis how does glucose enter mitochondria without breaking down to pyruvate?
    A:Meaning the entry of lactate into the blood stream inappropriately, which would usually be called aerobic glycolysis, though you can't be sure how much oxygen is getting to the cells when CO2 is deficient, since its absence causes many problems in oxygen delivery and use.
    Q:So when CO2 isn't deficient glycolysis, meaning glucose to pyruvate, is fine?
    A:Yes, as part of oxidative metabolism, it's better than burning too much fat.

    (asked him this question after paul jaminet claimed ray would agree with him to use O6 oil to help eczema...)
    Q: Do you recommend someone try omega 6 supplementation from say safflower oil in an extreme case on eczema? Or will the omega 6 appear to heal the eczema because of lowered metabolism?
    A:Slowing metabolism and causing inflammation are its two basic functions.

    Q:My dad asked about what to do for his skin cancer
    A:Yes, avoidance of unsaturated fats is the most important thing.
    Aspirin, caffeine, and orange juice are protective.
    Keeping the TSH low is important, because it stimulates melanoma growth.

    Amino Acids. 2007 Jan;32(1):95-100. Epub 2006 May 15.
    Enhancement of transglutaminase activity and polyamine depletion in B16-F10
    melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of
    the in vivo metastatic potential.
    Lentini A, Forni C, Provenzano B, Beninati S.
    Department of Biology, University of Rome Tor Vergata, Rome, Italy.
    The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin
    (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell
    were investigated. NG or HP treatment of melanoma cells produced a remarkable
    reduction of cell proliferation, paralleled with both the lowering of the
    intracellular levels of polyamine, spermidine and spermine and the enhancement of
    transglutaminase (TGase, EC activity. Orally administered NG or HP in
    C57BL6/N mice inoculated with B16-F10 cells affected the pulmonary invasion of
    melanoma cells in an in vivo metastatic assay. The number of lung metastases
    detected by a computerized image analyzer was reduced, compared to untreated
    animals, by about 69% in NG-treated mice and by about 36% in HP-treated mice.
    Survival studies showed that 50% of the NG-treated animals died 38 +/- 3.1 days
    after tumor cell injection (control group: 18 +/- 1.5 days) and HP-treated mice
    died 27 +/- 2.3 days after cell inoculation. Taken together, these findings
    provide further evidences for the potential anticancer properties of dietary
    flavonoids as chemopreventive agents against malignant melanoma.

    Biosci Biotechnol Biochem. 2000 Sep;64(9):1813-20.
    Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells.
    Iwashita K, Kobori M, Yamaki K, Tsushida T.
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
    We investigated the growth inhibitory activity of several flavonoids, including
    apigenin, luteolin, kaempherol, quercetin, butein, isoliquiritigenin, naringenin,
    genistein, and daizein against B16 mouse melanoma 4A5 cells. Isoliquiritigenin
    and butein, belonging to the chalcone group, markedly suppressed the growth of
    B16 melanoma cells and induced cell death. The other flavonoids tested showed
    little growth inhibitory activity and scarcely caused cell death. In cells
    treated with isoliquiritigenin or butein, condensation of nuclei and
    fragmentation of nuclear DNA, which are typical phenomena of apoptosis, were
    observed by Hoechst 33258 staining and by agarose gel electrophoresis of DNA.
    Flowcytometric analysis showed that isoliquiritigenin and butein increased the
    proportion of hypodiploid cells in the population of B16 melanoma cells. These
    results demonstrate that isoliquiritigenin and butein inhibit cell proliferation
    and induce apoptosis in B16 melanoma cells. Extracellular glucose decreased the
    proportion of hypodiploid cells that appeared as a result of isoliquiritigenin
    treatment. p53 was not detected in cells treated with either of these chalcones,
    however, protein of the Bcl-2 family were detected. The level of expression of
    Bax in cells treated with either of these chalcones was markedly elevated and the
    level of Bcl-XL decreased slightly. Isoliquiritigenin did not affect Bcl-2
    expression, but butein down-regulated Bcl-2 expression. From these results, it
    seems that the pathway by which the chalcones induce apoptosis may be independent
    of p53 and dependent on proteins of the Bcl-2 family. It was supposed that
    isoliquiritigenin induces apoptosis in B16 cells by a mechanism involving
    inhibition of glucose transmembrane transport and promotion of Bax expression. On
    the other hand, it was suggested that butein induces apoptosis via
    down-regulation of Bcl-2 expression and promotion of Bax expression. This
    mechanism differs from the isoliquiritigenin induction pathway.

    Endocr Relat Cancer. 2006 Dec;13(4):1269-77.
    Human melanoma cells express functional receptors for thyroid-stimulating
    Ellerhorst JA, Sendi-Naderi A, Johnson MK, Cooke CP, Dang SM, Diwan AH.
    Department of Experimental Therapeutics, Unit 362, University of Texas, MD
    Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, USA.
    We have reported a high prevalence of hypothyroidism in the cutaneous melanoma
    population, suggesting that the pathologic hormonal environment of hypothyroidism
    promotes melanoma growth. The objective of this study was to test the hypothesis
    that TSH, which circulates at elevated levels in hypothyroid individuals,
    stimulates the growth of melanoma cells. Our results show that TSH receptors
    (TSHR) are expressed by virtually all cutaneous melanocytic lesions, including
    benign nevi, dysplastic nevi, and melanomas, with higher expression found in
    malignant and pre-malignant lesions. The finding of TSHR expression by human
    tumors is confirmed in cultured melanoma cells and melanocytes, in which TSHR
    expression is demonstrated by immunofluorescent staining, western blotting, and
    reverse transcriptase-PCR. Melanoma TSHR are functional, as evidenced by the
    ability of TSH to induce the formation of cAMP and to activate the
    mitogen-activated protein kinase (MAPK) pathway. Cultured melanoma cells, but not
    melanocytes, are induced to proliferate at a physiologically relevant
    concentration of TSH. Taken together, these data support the hypothesis that TSH
    is a growth factor for human melanoma. Our findings have broad clinical
    implications for the prevention of melanoma and the management of established

    Cancer Lett. 1995 Aug 16;95(1-2):221-5.
    Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by
    polyphenolic compounds.
    Menon LG, Kuttan R, Kuttan G.
    Amala Cancer Research Centre, Thrissur, Kerala, India.
    Several polyphenolic compounds were tested for the inhibition of lung metastasis
    induced by B16F10 melanoma cells in mice. Oral administration of polyphenols such
    as curcumin and catechin at concentrations of 200 nmol/kg body weight were found
    to inhibit the lung metastasis maximally as seen by the reduction in the number
    of lung tumor nodules (80%). Other polyphenols which inhibited the lung tumor
    nodule formation were rutin (71.2%), epicatechin (61%), naringin (27.2%) and
    naringenin (26.1%). The polyphenols which did not inhibit lung tumor nodule
    formation were quercetin, morin and ellagic acid. Consequent to the inhibition of
    the lung tumor nodules, the life span of animals treated with polyphenols was
    also found to be increased. Curcumin (143.85%), catechin (80.81%) and rutin
    (63.59%) had maximal increase in life span. The results indicate a possible use
    of these compounds in arresting the metastatic growth of tumor cells.

    Chem Biodivers. 2011 Jun;8(6):1152-62. doi: 10.1002/cbdv.201000311.
    In vitro Cytotoxic Activity of Extracts and Isolated Constituents of Salvia
    leriifolia Benth. against a Panel of Human Cancer Cell Lines.
    Tundis R, Loizzo MR, Menichini F, Bonesi M, Colica C, Menichini F.
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and
    Health Sciences, University of Calabria, I-87036 Rende (CS) (phone:
    +39-0984-493246; fax: +39-0984-493298). tundis@unical.it.
    In the course of recent efforts to identify new potential antiproliferative
    active principles, Salvia leriifolia extracts and isolated constituents were
    evaluated for their cytotoxic activity against a panel of human cancer cell
    lines, including renal adenocarcinoma (ACHN), amelanotic melanoma (C32),
    colorectal adenocarcinoma (Caco-2), lung large cell carcinoma (COR-L23),
    malignant melanoma (A375), lung carcinoma (A549), and hepatocellular carcinoma
    (Huh-7D12) cells. The hexane and CH(2) Cl(2) extracts showed the strongest
    cytotoxic activity against the C32 cell line with IC(50) values of 11.2 and
    13.6 μg/ml, respectively, and the AcOEt extract was the most active extract
    against the COR-L23 cell line (IC(50) of 20.9 μg/ml). Buchariol, a sesquiterpene
    obtained by biofractionation of the CH(2) Cl(2) extract, exhibited a higher
    activity than the positive control vinblastine against the C32 and A549 cell
    lines (IC(50) values of 2.1 and 12.6 μM, resp.). Interesting results were also
    obtained for naringenin, a flavonoid isolated from the AcOEt extract, which
    exhibited a strong cytotoxic activity against the C32, LNCaP, and COR-L23 cell
    lines (IC(50) values of 2.2, 7.7, and 33.4 μM, resp.), compared to vinblastine
    (IC(50) values of 3.3, 32.2, 50.0 μM, resp.). None of the tested compounds
    affected the proliferation of skin fibroblasts (142BR), suggesting a selective
    activity against tumor cells.

    Biosci Biotechnol Biochem. 2006 Jun;70(6):1499-501.
    Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16
    melanoma cells.
    Ohguchi K, Akao Y, Nozawa Y.
    Gifu International Institute of Biotechnology. kohguchi@giib.or.jp
    Naringenin is a naturally occurring citrus flavanone. In this study, we examined
    the effect of naringenin on melanogenesis in mouse B16 melanoma cells. Melanin
    contents and tyrosinase activities were strongly increased by naringenin.
    Naringenin was found to cause marked increases in the expression levels of
    melanogenic enzymes.

    J Exp Clin Cancer Res. 2001 Jun;20(2):287-92.
    Effect of Caffeine, a xanthine derivative, in the inhibition of experimental lung
    metastasis induced by B16F10 melanoma cells.
    Gude RP, Menon LG, Rao SG.
    Chemotherapy & Stem Cell Biology Division. Cancer Research Institute, Parel,
    Mumbai, India. cri@soochak.ncst.ernet.in
    Caffeine, a methyl xanthine derivative, was studied to assess the effect on
    B16F10 melanoma induced experimental metastasis. Caffeine was administered at a
    dose of 100 and 50 mg/kg body weight by both routes, to tumour bearing animals.
    Solid tumour reduction studies with Caffeine showed a significant reduction in
    tumour volume for 100 mg/kg dose by both oral and i.p. routes. The Caffeine
    treated metastatic tumour bearing animals significantly (p<0.001) inhibited lung
    tumour nodules. Serum sialic acid levels and lung hydroxyproline contents in the
    treated groups were significantly (p<0.001) low, when compared with the untreated
    control animals. In the present study, our results suggest that Caffeine inhibits
    solid tumour development and pulmonary experimental metastasis induced by B16F10 melanoma cells, in murine model.

    Biochim Biophys Acta. 2000 Dec 11;1499(1-2):1-10.
    Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on
    the expression of cell cycle blocks and S-phase content after irradiation damage.
    Bohm L, Theron T, Binder A.
    Department of Radiation Oncology, Faculty of Medicine, University of
    Stellenbosch, P.O. Box 19063, 7505, Tygerberg, South Africa. elb@gerga.sun.ac.za
    The toxicity of the five methylxanthine derivatives, caffeine, pentoxifylline,
    A802710, propentofylline and A802715, was determined against the two human
    melanoma lines, Be11 and MeWo, and against the two human squamous cell carcinoma
    lines, 4197 and 4451, by vital dye staining assay. Pentoxifylline and A802710
    emerge as the least toxic showing TD(50) (toxic dose of 50%) levels of 3.0-4.0
    mM. Propentofylline and caffeine take an intermediate position. A802715 has a
    TD(50) of 0.9-1.1 mM and is the most toxic. Subtoxic concentrations (<TD50)added
    after irradiation at maximum expression of the G2/M block show that
    pentoxifylline and A802710 effectively abrogate the G2/M block, whereas A802715
    and propentofylline prolong the G2/M block or remain ineffective depending on the
    p53 status of the cell line. In p53 wt cells BrdU incorporations show that the
    irradiation-induced suppression of S-phase entry is marginally enhanced by
    pentoxifylline but strongly enhanced by propentofylline and A802715. This effect
    was not seen in p53 mutant cells. Since propentofylline and A802715 prolong the
    G2/M block and effectively suppress BrdU incorporation these two drugs emerge as
    antagonists to pentoxifylline, caffeine and A802710. Common structural features
    of propentofylline and A802715 are a propyl substituent at the N7 position in
    contrast to pentoxifylline, caffeine and A802710 where the N7 substituent is a
    methyl group. The results document the effectiveness of four methylxanthines in
    influencing cell regulation and damage response in human tumor cells.

    Melanoma Res. 1998 Apr;8(2):131-7.
    Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased
    invasion and proliferation.
    Lentini A, Kleinman HK, Mattioli P, Autuori-Pezzoli V, Nicolini L, Pietrini A,
    Abbruzzese A, Cardinali M, Beninati S.
    Department of Biology, II University of Rome Tor Vergata, Italy.
    Theophylline- and caffeine-treated B16-F10 cells exhibited low adhesion to
    laminin/collagen type IV and reduced invasion through Matrigel in an in vitro
    assay. In contrast, theobromine appeared ineffective. When young adult C57BL/6
    mice were injected intravenously with theophylline-treated B16-F10 cells, the
    number of surface lung tumours was markedly reduced. Densitometric analyses
    performed on digitalized microscopic images of histological sections of lung were
    used to estimate the frequency (number of lung foci; NLF) and the size (average
    area of metastatic foci; AMF) of the resulting tumour foci. These parameters were
    correlated to the proliferation (AMF) and invasion (NLF) of melanoma cells in
    vivo. The data showed a similar theophylline-induced decrease in the AMF and NLF
    values (71%, P < 0.01). Caffeine treatment produced a more pronounced decrease in
    the AMF (61%, P < 0.01) than in the NLF (25%, P < 0.01). To our knowledge, this
    is the first demonstration that theophylline and caffeine possess the capacity to
    inhibit not only cell proliferation, but also the metastatic behaviour of
    melanoma cancer cells.

    Prostaglandins. 1996 Jan;51(1):1-17.
    Identification of arachidonic acid pathways required for the invasive and
    metastatic activity of malignant tumor cells.
    Reich R, Martin GR.
    Department of Pharmacology, Hebrew University of Jerusalem, Israel.
    Metastasis is a complex process, almost a cascade, involving multiple steps and
    activities. However, an important factor is that malignant cells are able to
    penetrate through the multiple basement membrane barriers surrounding tissues,
    blood vessels, nerves and muscle that would otherwise block their dissemination.
    Penetration of malignant tumor cells through basement membrane is an active
    process requiring proteolysis. We report here that inhibitors of both the
    cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism convert
    mouse melanoma and human fibrosarcoma cells to a non invasive state by reducing
    the production of MMP-2, an enzyme required for the degradation of basement
    membranes. Specific metabolites of each pathway, i.e. PGF2 alpha and 5-HPETE, are
    able to transcend the block and restore collagenase production, invasiveness in
    vitro and metastatic activity in vivo. These studies indicate a key role for
    arachidonic acid metabolites in metastasis and suggest novel therapeutic
    approaches for inhibiting the spread of cancer.

    Chemotherapy. 2003 May;49(1-2):71-5.
    Potentiation of lipid peroxidation in B16F10 and B16F1 melanoma cells by
    caffeine, a methylxanthine derivative: relationship to intracellular glutathione.
    Shukla V, Gude RP.
    Chemotherapy Division, Cancer Research Institute, Tata Memorial Centre, Mumbai,
    BACKGROUND: Caffeine has shown an inhibitory role in invasion and proliferation
    in melanoma pulmonary metastasis as well as in high-grade tissue sarcoma.
    However, little is known about its mechanism and possible role in metastatic cell
    MATERIALS AND METHODS: B16F10 and B16F1 cell lines of high and low metastatic
    potential were treated with caffeine at different time intervals with different
    doses. Reduced glutathione, glutathione S-transferase and lipid peroxides were
    estimated to evaluate the effect of caffeine.
    RESULTS: Caffeine treatment showed glutathione depletion and increased lipid
    peroxidation with higher glutathione S-transferase activity in both B16F10 and
    B16F1 cell lines. However the effect of caffeine was dependent on the time factor
    as well as on the dose.
    CONCLUSIONS: Caffeine was an effective inhibitor of metastatic activity.
    Glutathione depletion in conjunction with increased lipid peroxidation was a
    potent indicator in the regulation of metastatic behavior of B16F10 and B16F1
    melanoma cell lines.

    Mol Cell Biochem. 2008 Jan;308(1-2):193-200. Epub 2007 Oct 12.
    Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an
    ATM-PKCdelta-p38 MAPK-dependent mechanism.
    Ravi D, Muniyappa H, Das KC.
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 W
    Markham Street, Slot # 845, Little Rock, AR 72205, USA.
    Mammalian ultraviolet (UV) radiation response is a gene induction cascade
    activated by several transcription factors, including NF-kappaB. Although
    NF-kappaB is induced by UV radiation, the signal transduction mechanism remains
    relatively unclear. In the present study, we show that UV-induced NF-kappaB
    activation is mediated by the activation of Ataxia telangiecia mutated (ATM) and
    protein kinase C (PKC). We also show that caffeine specifically inhibits
    UV-mediated NF-kappaB activation, but not TNFalpha-mediated NF-kappaB activation.
    In addition, our study shows that ATM, but not ATM-Rad3-related (ATR) or
    DNA-dependent protein kinase (DNA-PK) is involved in UV-induced NF-kappaB
    activation. Because SB203580 (a p38 MAPK inhibitor), or Calphostin C or rottlerin
    (PKC inhibitors) was able to inhibit UV-mediated NF-kappaB activation, we
    evaluated whether caffeine could inhibit p38 MAPK or PKC activity. Caffeine or
    rottlerin inhibited UV-induced phosphorylation of p38 MAPK, but not
    anisomycin-induced phosphorylation of p38 MAPK, suggesting that p38 MAPK is
    downstream of PKC. Additionally, caffeine could effectively inhibit UV-induced
    increases in PKC activity. Taken together, our study demonstrates that caffeine
    is a potent inhibitor of UV-induced NF-kappaB activation. Additionally, this
    inhibition occurs due to the inhibitory action of caffeine on ATM and PKC,
    resulting in the inhibition of p38 MAPK activation.

    Eur J Cancer Clin Oncol. 1989 Oct;25(10):1413-7.
    Early presence of activated ('exhausted') platelets in malignant tumors (breast
    adenocarcinoma and malignant melanoma).
    Mannucci PM, Cattaneo M, Canciani MT, Maniezzo M, Vaglini M, Cascinelli N.
    A. Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy.
    To evaluate whether or not the finding of platelet activation in patients with
    tumors is related to the stage of malignancy, a study of biochemical markers
    indicative of the presence of circulating activated ('exhausted') platelets was
    carried out in 95 untreated patients with breast adenocarcinoma or malignant
    melanoma, localized or spread to regional lymph nodes with no detectable distant
    metastasis. These tumors were chosen as examples of tumors which can be
    accurately staged for localization or spread, and as examples of mucin-secreting
    tumors (breast adenocarcinoma) or neuroectodermic tumors (malignant melanoma).
    Results were compared with those for 26 patients with benign breast disease, 23
    blood donors and 50 hospital workers. The most frequent abnormalities were low
    levels of intraplatelet ADP and 5-hydroxytryptamine and high ATP/ADP ratios.
    Although these abnormalities occurred with both types of tumor, they were more
    frequent and marked for melanomas and breast carcinomas spread to regional lymph
    nodes. Our data indicate that the presence of exhausted platelets is an early
    finding in patients with malignant tumors.

    Br J Cancer. 1999 Nov;81(5):918-23.
    Oral contraceptive use and risk of melanoma in premenopausal women.
    Feskanich D, Hunter DJ, Willett WC, Spiegelman D, Stampfer MJ, Speizer FE,
    Colditz GA.
    Department of Medicine, Brigham and Women's Hospital and Harvard Medical School,
    Boston, MA 02115, USA.
    Melanoma has been increasing in white populations. Incidence rates rise steeply
    in women until about age 50, suggesting oestrogen as a possible risk factor.
    Oestrogens can increase melanocyte count and melanin content and cause
    hyperpigmentation of the skin. We examined prospectively the association between
    oral contraceptive (OC) use and diagnoses of superficial spreading and nodular
    melanoma among 183,693 premenopausal white women in the Nurses' Health Study
    (NHS) and the Nurses' Health Study II (NHS II) cohorts. One hundred and forty six
    cases were confirmed in NHS during follow-up from 1976 to 1994, and 106 cases
    were confirmed in NHS II from 1989 to 1995. Skin reaction to sun exposure,
    sunburn history, mole counts, hair colour, family history of melanoma, parity,
    height and body mass index were also assessed and included in logistic regression
    models. A significant twofold increase in risk of melanoma (relative risk (RR) =
    2.0, 95% confidence interval (CI) 1.2-3.4) was observed among current OC users
    compared to never users. Risk was further increased among current users with 10
    or more years of use (RR = 3.4, 95% CI 1.7-7.0). Risk did not appear elevated
    among past OC users, even among those with longer durations of use, and risk did
    not decline linearly with time since last use. In conclusion, risk of
    premenopausal melanoma may be increased among women who are current OC users,
    particularly among those with longer durations of use. Further research is needed
    to determine whether low-dose oestrogen pills in particular are associated with
    an increase in risk and to describe possible interactions between OC use and sun
    exposure or other risk factors for melanoma.

    Oncol Rep. 2005 Apr;13(4):559-83.
    Comment in:
    J Urol. 2005 Aug;174(2):787-8.
    Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer
    prevention: a critical review of non-selective COX-2 blockade (review).
    Harris RE, Beebe-Donk J, Doss H, Burr Doss D.
    College of Medicine and Public Health, The Ohio State University, 320 West 10th
    Avenue, Columbus, OH 43210-1240, USA. harris.44@osu.edu
    We comprehensively reviewed the published scientific literature on non-steroidal
    anti-inflammatory drugs (NSAIDs) and cancer and evaluated results based upon
    epidemiologic criteria of judgment: consistency of results, strength of
    association, dose response, molecular specificity, and biological plausibility.
    Sufficient data from 91 epidemiologic studies were available to examine the dose
    response of relative risk and level of NSAID intake for ten human malignancies.
    Dose response curves were fitted by exponential regression. Results showed a
    significant exponential decline in the risk with increasing intake of NSAIDs
    (primarily aspirin or ibuprofen) for 7-10 malignancies including the four major
    types: colon, breast, lung, and prostate cancer. Daily intake of NSAIDs,
    primarily aspirin, produced risk reductions of 63% for colon, 39% for breast,
    36% for lung, and 39% for prostate cancer. Significant risk reductions were also
    observed for esophageal (73%), stomach (62%), and ovarian cancer (47%). NSAID
    effects became apparent after five or more years of use and were stronger with
    longer duration. Observed protective effects were also consistently stronger for
    gastrointestinal malignancies (esophagus, stomach, and colon). Results for
    pancreatic, urinary bladder, and renal cancer were inconsistent. Initial
    epidemiologic studies of malignant melanoma, Hodgkin's disease, and adult
    leukemia also found that NSAIDs are protective. A few studies suggest that
    ibuprofen has stronger anticancer effects than aspirin, particularly against
    breast and lung cancer. Overexpression of cyclooxygenase-2 (COX-2) and increased
    prostaglandin biosynthesis correlates with carcinogenesis and metastasis at most
    anatomic sites. Preclinical investigations provide consistent evidence that both
    selective and non-selective NSAIDs effectively inhibit chemically-induced
    carcinogenesis of epithelial tumors. This review provides compelling and
    converging evidence that regular intake of NSAIDs that non-selectively block
    COX-2 protects against the development of many types of cancer.
  7. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Concerns of Fluoride in Gelatin

    Regarding concerns of fluoride in gelatin:

  8. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Oral Health

    Regarding oral health:

  9. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Ray Peat Thoughts on Fluoride/Bro

  10. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Regarding Taking Thyroid

    Regarding taking thyroid:

  11. j.

    j. Guest

    Re: Ray Peat Email Advice: Related to Intestinal Bacteria

    I mentioned to Ray Peat that I have some issues which I think are related to intestinal bacteria. He replied that travelers often pick up bacteria that can take a long time to change.

    Then I asked him about which antibiotics one could use.

  12. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Ray Peat Email Advice: Severe Sleep Apnea

  13. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Blood Test Results


  14. chris

    chris Member

    Oct 8, 2012
    I asked him about circumcision and he said it was almost exclusively negative unless their was some abnormalities with the foreskin i.e too tight.
  15. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice:Regarding medications being ototox

  16. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Mushrooms


  17. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice: Regarding Magnesium Salicylate

  18. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    :hattip Anon over at Peatarian.com.

    http://www.peatarian.com/?qa=7292/long- ... m-and-pufa

  19. OP

    charlie The Law & Order Admin

    Jan 4, 2012
    Re: Ray Peat Email Advice:Regarding Vitamin Ingestion vs Top


  20. OP

    charlie The Law & Order Admin

    Jan 4, 2012