Progesterone 5 Alpha Reductase

[Progesterone]

Progesterone is a female hormone that has been used topically on male scalps with excellent results. It is known to reduce 5alpha-reductase and thus interfere with DHT. In studies 1 nM finasteride inhibited DHT synthesis in DP by 86% and 1 nM progesterone by 75%.

One study confirmed progesterone is a 5alpha-reductase inhibitor but topical application is ineffective in men because of rapid metabolization. [R. Hoffman 2000]

^^ perhaps this is why ORAL PROG is better for hairloss...

Progesterone used in treatment of Androgenetic Alopecia | Male Pattern Baldness Cure Follacure.com

 

[meatbag]

Progesterone is a female hormone that has been used topically on male scalps with excellent results. It is known to reduce 5alpha-reductase and thus interfere with DHT. In studies 1 nM finasteride inhibited DHT synthesis in DP by 86% and 1 nM progesterone by 75%.

One study confirmed progesterone is a 5alpha-reductase inhibitor but topical application is ineffective in men because of rapid metabolization. [R. Hoffman 2000]

^^ perhaps this is why ORAL PROG is better for hairloss...

Progesterone used in treatment of Androgenetic Alopecia | Male Pattern Baldness Cure Follacure.com

I cant find the hoffman study, can you post a direct link please.

 

[Progesterone]

I cant find the hoffman study, can you post a direct link please.

Good point.

I can't find it either.

I read that from this link: Progesterone used in treatment of Androgenetic Alopecia | Male Pattern Baldness Cure Follacure.com

 

[Irish7777]

The neurosteroid allopregnanolone is synthesized from progesterone by the enzyme 5-AR. If progesterone was inhibiting 5-AR then it would not convert much into allopregnanolone. However, in reality progesterone converts very easily to allopregnanolone, which suggests that in living humans oral progesterone probably does NOT inhibit 5-AR and may even enhance it.

Haidut are you saying if you're concerned about the possibility of progesterone reducing 5ar it would be safer to use progesterone orally rather than topically?

The neurosteroid allopregnanolone is synthesized from progesterone by the enzyme 5-AR. If progesterone was inhibiting 5-AR then it would not convert much into allopregnanolone. However, in reality progesterone converts very easily to allopregnanolone, which suggests that in living humans oral progesterone probably does NOT inhibit 5-AR and may even enhance it.

The neurosteroid allopregnanolone is synthesized from progesterone by the enzyme 5-AR. If progesterone was inhibiting 5-AR then it would not convert much into allopregnanolone. However, in reality progesterone converts very easily to allopregnanolone, which suggests that in living humans oral progesterone probably does NOT inhibit 5-AR and may even enhance it.