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5-alpha reductase

  1. Hans

    The truth of vitamin B6 on DHT for hair growth

  2. Mauritio

    Dutasteride / Finasteride cause fibrosis of the penis and prostate; decrease androgen receptors, increase estrogen receptors

    If you contemplate taking finasteride/ dutasteride read this study. Or just ask yourself:" do I potentially want a fibrotic penis ?" Another reason not to take dutasteride or finasteride: they cause fibrosis of the penis and prostate and increase the expression of the estrogen receptor and...
  3. fever257

    HCG And Proviron - Are They Safe?

    Hello, I need to inquire about the safety of two separate drugs/steroids that I'm inclined to take. Both of these would be to optimize hormonal issues engendered by 5-AR blocking via finasteride. I'm positive that I need to push my system artificially with a drug in order to heal my hormones...
  4. J

    DHT Causes Hair Loss, You Sure About That?

    In the past I've heard georgi say dht actually grows hair and its high in hair loss sufferers because oestrogen is too high. He also says taurine grows hair better than finastride, note this study was in an insect less than the size of an ant. I have never seen any case report with proof than...
  5. haidut

    PUFA And MUFA Are Strong Inhibitors Of 5-AR, Saturated Fatty Acids Are Not

    I have posted quite a few studies showing the effects of various fatty acids on estrogen, androgen and glucocorticoid synthesis. This study shows that both PUFA and MUFA are strong inhbitors of 5-AR, with PUFA being the more potent inhibitors and inhibition potency being strongly dependent on...
  6. haidut

    5-AR Inhibitor Drugs Like Finasteride Cause Persistent ED And Lower Testosterone

    The FDA has denied for decades that the mainstream drugs for hair loss (MPB) and benign prostate enlargement (BPH) cause any persistent problems. It was in the minds of the users, the FDA said. Upon discontinuation, the problems were said to disappear within 2-4 weeks. But the reports on long...
  7. haidut

    A List Of Androgens That Stimulate 5-AR Activity

    Increasing 5-AR activity has received a lot of interest lately due to its therapeutic effects on mood disorders as well as issues with excess cortisol (5-AR deactivates cortisol). Unfortunately, the official story is that there are no freely available compounds that can stimulate 5-AR activity...
  8. haidut

    Androsterone - The Legal Pro-hormone For Potent 5-AR Derived Androgens

    Adnrosterone is a downstream metabolite of DHT and just like DHT it is a 5-AR derived steroid. What is even more interesting is that androsterone is not just a metabolite of DHT but can be converted back to DHT as needed in target tissues where DHT is needed. In fact, androsterone has at least 2...
  9. haidut

    Androsterone - A Potent Steroidal Aromatase Inhibitor

    It is well-known in medical circles (at least in doctors over 50) that some androgens like DHT are potent aromatase inhibitors (AI). In fact, before the advent of modern AI drugs like letrozole, anastrozole and fadrozole the 5-AR androgens were a mainstream therapy for estrogen-receptor-positive...
  10. haidut

    DHT Stimulates Its Own Synthesis

    The stress hormone estrogen is well-known for its ability to stimulate its own synthesis, resulting in a vicious circle. Some of the beneficial steroids like pregnenolone do the same, but for pretty much all others like T, cortisol, aldosterone, and even progesterone there is a feedback...
  11. haidut

    Glycine Strongly Upregulates 5-alpha Reductase (5-ar) Activity

    This is study is a great find in my opinion. It is well known that conditions like depression and dementia are associated with reduced levels of the neurosteroid allopregnanolone. A few of the successful SSRI drugs like Prozac have the "side effect" of increasing levels of allopregnanolone in...
  12. Zachs

    Coconut Oil Reduced DHT By Inhibiting 5-ar?

    This was something I researched a bit a few years ago when first learning about Ray Peat and his affinity for coconut oil. I actually asked him this question but he seemed to not know the answer. Lauric acid among other fatty acids is known for blocking the conversion of DHT by inhibiting...
  13. haidut

    Vitamin A Increases DHT By Enhancing 5-alpha Reductase

    Rat study, and it used preformed all-trans-retinoic acid (ATRA) but it should hold true for retinol and its various esters like retinyl acetate/palmitate. The human dosage for ATRA was in the range 500mg-700mg, which is a huge dose. http://www.ncbi.nlm.nih.gov/pubmed/10423178...
  14. O

    Progesterone 5 Alpha Reductase

    Hello I have question about progesterone. In some articles I read it says progesterone is a 5 alpha reductase inhibitor, in other places 5AR is involved in Progesterone function and conversion or something. I am a little confused by this. As you know 5AR is a culprit in hair loss. So in theory...
  15. haidut

    Caffeine Increases DHT By Enhancing 5-alpha Reductase

    I know many people who have taken drugs like Finasteride for hair loss and prostate enlargement (BPH). The mechanism of action of those drugs is inhibition of the enzyme 5-alpha reductase (5-AR) and thus lowering levels of DHT, since DHT is blamed for the hair and prostate issues. Actually, DHT...