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mitolab.com
That’s the stuff I’ve got. For myself 10 drops is the sweet spot. But I only use it if I feel the need, maybe once per week. Thanks for the input. I forgot about coconut oil, I’ll definitely be looking into it.I don't know but I can vouch for the service of this lot. I worked it out as 0.5mg/drop. You could start off low and work up slowly. I think I read here up to 5mg/day can be considered 'safe' but don't quote me. I wouldn't just start at that level either.
Methylene Blue – Solution (USP/BP) (30mL / 100mL)
High purity Methylene Blue in a 10mg/ml concentration. Warning: This product is sold for use in research scenarios. Not for human or veterinary use. Please see our Terms and Conditions for more inf…
There are also things like coconut oil to consider.
Interesting. Red light is something to look into as well I think.When I clicked on that mitolab.com link, I saw they had nicotine liquid as a featured product. This reminded me of this older thread about microdoses of nicotine helping rejuvenate old mice by vastly improving their NAD+/NADH ratio.
Microdosing nicotine increases NAD levels and rejuvenates old mice
This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice. Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels. This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in...raypeatforum.com
I have a mom suffering from similar issues but I don't really know what to do here. I'll be watching this thread with interest.
academic.oup.com
www.ryanheeney.com
Brain energy fails as people age. I believe that this is tied to the aging intestine losing its ability to absorb thiamine which results in a thiamine deficiency which causes cellular energy (including the cells in the brain) to fail. There's a lot of articles about the idea that thiamine deficiency is linked to all forms of dementia.
pubmed.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
Mind blowing results there.Low-dose Methylene Blue (MB) May Stop Alzheimer Disease (AD)
Another great result for the humble dye whose only claim medical fame so far has been as treatment for malaria, and even that "designation" has largely been deprecated due to the advent of new and "improved" drugs. About a decade ago, a company in the UK started researching MB as potential...
That would sense, there’s no way she’s getting enough copper.’Methylene blue does similar things like biotin.
Both increase heme synthesis, cytochrome C oxidase function and support oxidative phosphorylation.
Morley Robbins said in one of the conversations I had with him on the phone, that methylene blue is like a substitute for a copper-deprived mitochondria. So checking copper status is important and it’s deficiency is pathological factor in AD.
Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia†
Abstract. Datasets comprising simultaneous measurements of many essential metals in Alzheimer's disease (AD) brain are sparse, and available studies are no
No, I haven’t. I’ll go through it thanks.Great find, thanks for posting!
This is also a very good article I found here, not sure if you've seen it @Disrupt It All
Ryan doesn't seem to post here any more which is a shame.
What Is Methylene Blue? — Ryan Heeney
Nice find @dmoon
Yeah I remember reading about this before. Definitely something to add to the list of things I’ll be trying.Brain energy fails as people age. I believe that this is tied to the aging intestine losing its ability to absorb thiamine which results in a thiamine deficiency which causes cellular energy (including the cells in the brain) to fail. There's a lot of articles about the idea that thiamine deficiency is linked to all forms of dementia.
Suggested articles and links:
Vitamin B1 (thiamine) and dementia - PubMed
The earliest and perhaps best example of an interaction between nutrition and dementia is related to thiamine (vitamin B1). Throughout the last century, research showed that thiamine deficiency is associated with neurological problems, including cognitive deficits and encephalopathy. Multiple...
Hiding in Plain Sight: Modern Thiamine Deficiency
Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including ...4.6. Neurocognitive and Neuromotor Diseases
Neurocognitive and neuromotor disturbances represent the final common pathways of longstanding TD. Despite different genetic origins, several lines of evidence find associations between thiamine and Alzheimer’s [50], Parkinson’s [51], and Huntington’s diseases [52], and dementia [53], but the research on deficiency and treatment is equivocal [54]. Underlying each of these, however, is altered glucose handling, which, as will become evident later, is a hallmark of insufficient thiamine.
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There are several thiamine types available. Dr. Costantini always used thiamine hcl for his Parkinson's Disease patients. The collection of patient before and after videos are eye opening.
