@nejdev
@AdoTintor
Cinchona?
General info, dosing, example of what to buy:
HCQ vs quinine bark
Risks of using the bark:
About the binding affinities of plant chemicals that bind to the ACE2 receptor, details of black cumin seed chemical composition, blood brain barrier permeability of chemicals in black cumin seed oil and effects on protein receptors that affect neurodegeneration
Comparing practicality and reliability of black cumin seed oil, cinchona bark, HCQ, and chloroquine; also comparisons of binding affinities of Ivermectin, HCQ, and chloroquine:
Quinine and HCQ have different half-lives so how to dose an amount of quinine in cinchona bark similarly to Zelenko's prophylaxis protocol HCQ doses; risks of cinchona bark compared to synthetic derivatives
A picture of 2 grams of cinchona bark so people who don't have a scale can eyeball their dose estimate better than I did (so they don't get cinchonism symptoms)
Uncertainties of mine about how to compare Zelenko's recommended HCQ doses with safe cinchona bark doses, considering that cinchona bark has lots of other chemicals in it that interact with the quinine effects
____________________________
Conversation between AdoTintor and I...
Ado:
Hi 863127, how are your the experiments with cinchona bark going?
I was looking at your calculations. You can do an infinite sum for the quinine dose and there is a formula for this. So if you imagine dosing an amount q every 12 hours you will have in blood: total=q+qa+qa^2+qa^3+qa^4+.....=q/(1-a), where "a" is the fraction remaining after 12 hours which in this case is 0.5 as it is the halflife. Hence Total=2*q. Hence to get 1000mg you need to dose 500mg every 12 hours which is what you got, inelegantly :)
I need to have 1000mg in my blood for one encounter (lecture) per week. So potentially I could simply dose up in the morning with two 500mg teas, ie 20g of bark. Not sure about the merits of that - although I see that the capsule dose the recommend for adults is about 600mg in one dose. I guess I will not know if my bark is 5%
I am just trying 2g of bark tea and its pretty hard to drink - have you done the 10g tea? By the way do you know a good source that will send to UK?
Ado
Me:
So you have a scale you're weighing 2 grams with? Will you put a quarter or lighter or something next to it and take a picture?I haven't been using cinchona bark much because I've been using Ivermectin and other herbs and keep forgetting to buy a scale so I can try cinchona better. When I got the bark, I used about the same amount of it I would usually use of other strong "herbs" (denser parts of the plant like seeds or bark) when I'm making a quart of tea, because I didn't have a scale. I got cinchonism symptoms from that, starting within about a half hour and not starting to lessen much until at least three or four days later.
One thing that I'm not sure of the importance of when figuring out dosing cinchona compared to isolated quinine or HCQ is the other chemicals in cinchona maybe supporting, complementing, preparing the biochemical context, somehow making the quinine in the bark effectively like more of an isolated dose. Maybe that's why traditional use is an amount that would be ~100-300 mg quinine per cup and two or three cups a day, so not 1000 mg ingested per day, and not 1000 mg being maintained in the blood. But maybe the dosage for spike proteins should be a high dose of quinine even when it's with the supporting other chemicals, and so a problem with using cinchona for that, instead of isolated quinine/HCQ, would be the increased risk of cinchonism symptoms, because the effective potentizing of the quinine and/or other chemicals.
2 g is hard to drink because the taste? You're not getting any mild but noticeable symptoms from that amount? About that and the previous paragraph -- maybe for using it against the spike proteins (and maybe even moreso for the modified vaccine proteins?), it'll be a narrow range between a thoroughly effective enough dose and a dose that causes cinchonism symptoms (and those can take months to get completely better) so that dosage experimentation could be an important thing to be more careful about with cinchona compared to isolated quinine/HCQ?
Here's a business in the UK that sells cinchona bark:
Ado:
I read most of your posts and saw your report about cinchonism symptoms and have been very careful. Only been trying 2g in a tea and taking it each day for last 3 days. BTW I just boil it for 15 mins? I got no symptoms and yes it tastes bitter but am used to it. Never tried 10g but can only imagine the taste will be truly awful.
The dosage is really unclear because you are right that there may be other stuff - and the collective coverage is not just 100mg quinine but also 100mg of X, Y, Z. I will try the bark option and see if I feel terrible after the first lecture. Immediately take IVM if so. I suppose I should not take HCQ at that point is qininine is still high - all these unknowns.
I took 2 days of IVM and the 5 days of HCQ. I didnt like the feeling - felt like it put a whole in my head for a bit. And I think got a lot of shedding (hair!) - you get that? So want to try something else. At moment the H1+H2 and olive leaf tea, adndrographis, D2, quercetin seems to feel good and protect me when shopping etc
Ado:
I forgot to say that there is a haidut quote on the forum that basically says HCQ is big pharmas more toxic version of quinine. That was the game changer for me.
Me:
I didn't know anything about quinine or HCQ until this stuff recently. But that just makes me think that if I had a choice between isolated quinine or HCQ then now I'd consider the quinine more than before reading that. But there's still the issue of all the other stuff in the cinchona bark and how it interacts when drinking the tea regularly for prevention.
I mean I'm doubtful about HCQ's toxicity complicating using either for prophylaxis more than the other stuff in cinchona bark complicating it. On the other hand, the other chemicals in cinchona bark help the quinine some ways. So maybe the question becomes what dose of quinine from cinchona bark, with the other stuff, is equivalent to a dose of HCQ. Maybe when I did the half life dosing schedule for 500 mg, assuming it should be the same milligrams in the blood of quinine as Zelenko recommends for HCQ, maybe that's not a good assumption. Maybe it should be less.
Ado:
Before I had read that comment I didnt even know there was a connection between HCQ and quinine, and I was only interested in HCQ. After that I really became interested in the idea of quinine.
Is chinchism from pure quinine overdose or the other things in the bark? If we put the dose of bark up so that we get 1000mg of quinine could end up getting chinchism from the other things in the bark? Hmm. It would be good to find out more on standard (tribal) usage
Me:
Yeah I learned about quinine pretty much the same approach. And yeah I should try to find a good resource, maybe from around mid-20th century when cinchona vs synthetics was important, reviewing traditional uses of cinchona. I found an interesting report from the late 1800s about cinchonism:
(from this post: Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that )
"Some full papers about cinchonism:
This is an interesting one, from when cinchona bark was commonly used as a tea for quinine:
Some of the Graver and Rarer Forms of Cinchonism by I.E. Atkinson, 1889
Ado:
from the last paper it looks like it is directly from quinine, as they are only giving quinine grains. Can we get grains of pure quinine?
Me:
Oh. I only skimmed it.
I searched "buy quinine grains" and found stuff from museums and historians. I read this article:
and it says:
1 grain = 0.06479891 grams
So as long as what we get nowadays in a tablet or pill or whatever is quinine sulphate, I think that conversion's all we need to know about the grains to compare with currently available isolated quinine?
Ado:
ok - so you could try QS and see if you get symptoms from the pure form. I think I remember two tablets was 600mg the stated dose - then I can be sure to be almost near the 1000mg.
Really I have no way of knowing anything of bark quality.
But I suppose the real issue is that we are matching 1000mg of HCQ in blood as being equivalent to 1000mg of qinine? This is not necessarily going to be the same as HCQ is a derivative of qininine. For example if qinine turns into 50% HCQ then....
Me:
I was looking for common quinine sulphate dosages and found this -- lots of details of contraindications and things to consider depending on a person's disease conditions when using it.
I also found this...
"...This medication is used to kill the malaria parasites living inside red blood cells. In some cases, you may need to take a different medication (such as primaquine ) to kill the malaria parasites living in other body tissues. Both drugs [quinine and primaquine] may be needed for a complete cure and to prevent the return of infection (relapse)..."
And I thought primaquine was one of the chemicals in cinchona bark, but it's not.
(showing these again)
"The main plant chemicals found in quinine [cinchona] bark include: aricine, caffeic acid, cinchofulvic acid, cincholic acid, cinchonain, cinchonidine, cinchonine, cinchophyllamine, cinchotannic acid, cinchotine, conquinamine, cuscamidine, cuscamine, cusconidine, cusconine, epicatechin, javanine, paricine, proanthocyanidins, quinacimine, quinamine, quinic acid, quinicine, quinine, quininidine, quinovic acid, quinovin, and sucirubine."
Primequine's a synthetic 8-aminoquinoline derivative.
"Primaquine is a synthetic, 8-aminoquinoline derivative with antimalarial properties... Primaquine is an aminoquinoline that has been used for the prevention and therapy of malaria for more than 50 years..."
"8-Aminoquinoline is the 8-amino derivative of quinoline."
"Cinchona bark contains quinoline alkaloids. Quinine, quinidine, cinchonine , and cinchonidine are the major substances among over thirty others (McCalley 2002)"
"The main plant chemicals found in quinine [cinchona] bark include: aricine, caffeic acid, cinchofulvic acid, cincholic acid, cinchonain, cinchonidine, cinchonine, cinchophyllamine, cinchotannic acid, cinchotine, conquinamine, cuscamidine, cuscamine, cusconidine, cusconine, epicatechin, javanine, paricine, proanthocyanidins, quinacimine, quinamine, quinic acid, quinicine, quinine, quininidine, quinovic acid, quinovin, and sucirubine."
"Quinine is very similar to quinidine. Do not use medications containing quinidine while using quinine."
So "very similar" meaning that in some ways the dosages of each are cumulative with each other?
So my point is that there are chemicals in cinchona bark that do (very similarly, worse, better?) what primaquine in combination with quinine sulphate does, because primaquine is a synthetic derivative of those chemicals in cinchona. I mean the added efficacy with malaria of primaquine's combinaton with quinine might not be very relevant for spike protein stuff, but it's an example like, similar to, the potential of the mixture of chemicals in cinchona to be more effective than one chemical being isolated from it and said to be the only "active" chemical that you want from cinchona.
But on the other hand, part two of the point, those chemicals other than quinine in cinchona might (? I don't know enough about it) need to be recognized as effectively adding to the dosage of the quinine, which could be why (it seems, from what I've read) that the traditional tribal use of cinchona bark (avoiding cinchonism symptoms) was an amount that wouldn't make a dose of quinine from it that's as much as the isolated HCQ doses for the spike protein, and that might be because of the effectively cumulative dosages of the similar chemicals adding up to be more like the isolated HCQ doses.
@AdoTintor
Cinchona?
General info, dosing, example of what to buy:
Covid "Vaccine" Adverse Reaction Reports (Post Here)
What about using pancreatic enzymes to dissolve the nanolipid envelope and allow for the mRNA to be destroyed quickly? Any thoughts on that?
raypeatforum.com
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
That is very true and I agree 100% but since I am looking for substances to have around in case of an acute infection, ivermectin seems like the best solution. You even mentioned it "standardized dosages, shelf-stability" etc... Much more convenient than having to research medicinal plants for...
raypeatforum.com
HCQ vs quinine bark
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
Not sure where to put this so I'm putting it here. Jaclyn Hord keeps posting and retweeting intelligent stuff and seems to be an insider: Nice link, thanks. Found this neat primer on her new twitter page: Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine "The...
raypeatforum.com
Risks of using the bark:
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
That is very true and I agree 100% but since I am looking for substances to have around in case of an acute infection, ivermectin seems like the best solution. You even mentioned it "standardized dosages, shelf-stability" etc... Much more convenient than having to research medicinal plants for...
raypeatforum.com
About the binding affinities of plant chemicals that bind to the ACE2 receptor, details of black cumin seed chemical composition, blood brain barrier permeability of chemicals in black cumin seed oil and effects on protein receptors that affect neurodegeneration
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
Hey guys, remember how I posted that Walter Chestnut was saying Covid essentially turned your body into a one big horrific allergic overreaction? Long Covid patients immediately turned up and said all of them are taking two types of antihistamines to control their symptoms. Then people with...
raypeatforum.com
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
Hey guys, remember how I posted that Walter Chestnut was saying Covid essentially turned your body into a one big horrific allergic overreaction? Long Covid patients immediately turned up and said all of them are taking two types of antihistamines to control their symptoms. Then people with...
raypeatforum.com
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
Hey guys, remember how I posted that Walter Chestnut was saying Covid essentially turned your body into a one big horrific allergic overreaction? Long Covid patients immediately turned up and said all of them are taking two types of antihistamines to control their symptoms. Then people with...
raypeatforum.com
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
Hey guys, remember how I posted that Walter Chestnut was saying Covid essentially turned your body into a one big horrific allergic overreaction? Long Covid patients immediately turned up and said all of them are taking two types of antihistamines to control their symptoms. Then people with...
raypeatforum.com
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
So if thymohydroquinone is BBB and CNS permeable, I'd guess that thymoquinone and other things in the black cumin seed oil are too. I'd also guess that the combination of chemicals in the oil... (like in the first table in this post: Transmissible Viral Vaccines... how the shots are affecting...
raypeatforum.com
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
So if thymohydroquinone is BBB and CNS permeable, I'd guess that thymoquinone and other things in the black cumin seed oil are too. I'd also guess that the combination of chemicals in the oil... (like in the first table in this post: Transmissible Viral Vaccines... how the shots are affecting...
raypeatforum.com
Comparing practicality and reliability of black cumin seed oil, cinchona bark, HCQ, and chloroquine; also comparisons of binding affinities of Ivermectin, HCQ, and chloroquine:
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
So if thymohydroquinone is BBB and CNS permeable, I'd guess that thymoquinone and other things in the black cumin seed oil are too. I'd also guess that the combination of chemicals in the oil... (like in the first table in this post: Transmissible Viral Vaccines... how the shots are affecting...
raypeatforum.com
Quinine and HCQ have different half-lives so how to dose an amount of quinine in cinchona bark similarly to Zelenko's prophylaxis protocol HCQ doses; risks of cinchona bark compared to synthetic derivatives
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
Oh yeah. Cool. Thanks. thymoquinone in seeds (in mg) 0.0098 - 0.376 % of weight I found this volume to weight conversion for black cumin seeds...
raypeatforum.com
A picture of 2 grams of cinchona bark so people who don't have a scale can eyeball their dose estimate better than I did (so they don't get cinchonism symptoms)
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
do you know how they get the placebo vaccines, do they have special doctors who are also anti vaccine and give them placebo? I know they're not as stupid as the rest. They shoot sitting ducks. They aren't the sitting ducks.
raypeatforum.com
Uncertainties of mine about how to compare Zelenko's recommended HCQ doses with safe cinchona bark doses, considering that cinchona bark has lots of other chemicals in it that interact with the quinine effects
Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that
do you know how they get the placebo vaccines, do they have special doctors who are also anti vaccine and give them placebo? I know they're not as stupid as the rest. They shoot sitting ducks. They aren't the sitting ducks.
raypeatforum.com
____________________________
Conversation between AdoTintor and I...
Ado:
Hi 863127, how are your the experiments with cinchona bark going?
I was looking at your calculations. You can do an infinite sum for the quinine dose and there is a formula for this. So if you imagine dosing an amount q every 12 hours you will have in blood: total=q+qa+qa^2+qa^3+qa^4+.....=q/(1-a), where "a" is the fraction remaining after 12 hours which in this case is 0.5 as it is the halflife. Hence Total=2*q. Hence to get 1000mg you need to dose 500mg every 12 hours which is what you got, inelegantly :)
I need to have 1000mg in my blood for one encounter (lecture) per week. So potentially I could simply dose up in the morning with two 500mg teas, ie 20g of bark. Not sure about the merits of that - although I see that the capsule dose the recommend for adults is about 600mg in one dose. I guess I will not know if my bark is 5%
I am just trying 2g of bark tea and its pretty hard to drink - have you done the 10g tea? By the way do you know a good source that will send to UK?
Ado
Me:
So you have a scale you're weighing 2 grams with? Will you put a quarter or lighter or something next to it and take a picture?I haven't been using cinchona bark much because I've been using Ivermectin and other herbs and keep forgetting to buy a scale so I can try cinchona better. When I got the bark, I used about the same amount of it I would usually use of other strong "herbs" (denser parts of the plant like seeds or bark) when I'm making a quart of tea, because I didn't have a scale. I got cinchonism symptoms from that, starting within about a half hour and not starting to lessen much until at least three or four days later.
One thing that I'm not sure of the importance of when figuring out dosing cinchona compared to isolated quinine or HCQ is the other chemicals in cinchona maybe supporting, complementing, preparing the biochemical context, somehow making the quinine in the bark effectively like more of an isolated dose. Maybe that's why traditional use is an amount that would be ~100-300 mg quinine per cup and two or three cups a day, so not 1000 mg ingested per day, and not 1000 mg being maintained in the blood. But maybe the dosage for spike proteins should be a high dose of quinine even when it's with the supporting other chemicals, and so a problem with using cinchona for that, instead of isolated quinine/HCQ, would be the increased risk of cinchonism symptoms, because the effective potentizing of the quinine and/or other chemicals.
2 g is hard to drink because the taste? You're not getting any mild but noticeable symptoms from that amount? About that and the previous paragraph -- maybe for using it against the spike proteins (and maybe even moreso for the modified vaccine proteins?), it'll be a narrow range between a thoroughly effective enough dose and a dose that causes cinchonism symptoms (and those can take months to get completely better) so that dosage experimentation could be an important thing to be more careful about with cinchona compared to isolated quinine/HCQ?
Here's a business in the UK that sells cinchona bark:
Dried Flowers & Herbs Wholesale - Product List | Joseph Flach & Sons
JFS stocks hundreds of products and the list below is a summary of current stock. If it's not listed here then please contact us to see if we can obtain it.
www.josephflach.co.uk
Ado:
I read most of your posts and saw your report about cinchonism symptoms and have been very careful. Only been trying 2g in a tea and taking it each day for last 3 days. BTW I just boil it for 15 mins? I got no symptoms and yes it tastes bitter but am used to it. Never tried 10g but can only imagine the taste will be truly awful.
The dosage is really unclear because you are right that there may be other stuff - and the collective coverage is not just 100mg quinine but also 100mg of X, Y, Z. I will try the bark option and see if I feel terrible after the first lecture. Immediately take IVM if so. I suppose I should not take HCQ at that point is qininine is still high - all these unknowns.
I took 2 days of IVM and the 5 days of HCQ. I didnt like the feeling - felt like it put a whole in my head for a bit. And I think got a lot of shedding (hair!) - you get that? So want to try something else. At moment the H1+H2 and olive leaf tea, adndrographis, D2, quercetin seems to feel good and protect me when shopping etc
Ado:
I forgot to say that there is a haidut quote on the forum that basically says HCQ is big pharmas more toxic version of quinine. That was the game changer for me.
Dating and Working in a Vaccinated World
Thank you Makrosky. I was hoping for something natural as opposed to supplemental. I am very sensitive to supplements. NAC leaves me feeling like I am having a heart attack and anxiety attack. I will look into the others. I appreciate your answer. HCQ is just a patented, and more toxic...
raypeatforum.com
Me:
I didn't know anything about quinine or HCQ until this stuff recently. But that just makes me think that if I had a choice between isolated quinine or HCQ then now I'd consider the quinine more than before reading that. But there's still the issue of all the other stuff in the cinchona bark and how it interacts when drinking the tea regularly for prevention.
I mean I'm doubtful about HCQ's toxicity complicating using either for prophylaxis more than the other stuff in cinchona bark complicating it. On the other hand, the other chemicals in cinchona bark help the quinine some ways. So maybe the question becomes what dose of quinine from cinchona bark, with the other stuff, is equivalent to a dose of HCQ. Maybe when I did the half life dosing schedule for 500 mg, assuming it should be the same milligrams in the blood of quinine as Zelenko recommends for HCQ, maybe that's not a good assumption. Maybe it should be less.
Ado:
Before I had read that comment I didnt even know there was a connection between HCQ and quinine, and I was only interested in HCQ. After that I really became interested in the idea of quinine.
Is chinchism from pure quinine overdose or the other things in the bark? If we put the dose of bark up so that we get 1000mg of quinine could end up getting chinchism from the other things in the bark? Hmm. It would be good to find out more on standard (tribal) usage
Me:
Yeah I learned about quinine pretty much the same approach. And yeah I should try to find a good resource, maybe from around mid-20th century when cinchona vs synthetics was important, reviewing traditional uses of cinchona. I found an interesting report from the late 1800s about cinchonism:
(from this post: Transmissible Viral Vaccines... how the shots are affecting those who haven't taken it. They may be designed to do exactly that )
"Some full papers about cinchonism:
This is an interesting one, from when cinchona bark was commonly used as a tea for quinine:
Some of the Graver and Rarer Forms of Cinchonism by I.E. Atkinson, 1889
Ado:
from the last paper it looks like it is directly from quinine, as they are only giving quinine grains. Can we get grains of pure quinine?
Me:
Oh. I only skimmed it.
I searched "buy quinine grains" and found stuff from museums and historians. I read this article:
Quinine Wisdom from Morris Boris Jacobs
For a while now I’ve been searching for academic looks at tonic water and have come up dry. How could something so economically significant be so poorly written about? Finding something usefu…
www.bostonapothecary.com
and it says:
1 grain = 0.06479891 grams
So as long as what we get nowadays in a tablet or pill or whatever is quinine sulphate, I think that conversion's all we need to know about the grains to compare with currently available isolated quinine?
Ado:
ok - so you could try QS and see if you get symptoms from the pure form. I think I remember two tablets was 600mg the stated dose - then I can be sure to be almost near the 1000mg.
Really I have no way of knowing anything of bark quality.
But I suppose the real issue is that we are matching 1000mg of HCQ in blood as being equivalent to 1000mg of qinine? This is not necessarily going to be the same as HCQ is a derivative of qininine. For example if qinine turns into 50% HCQ then....
Me:
I was looking for common quinine sulphate dosages and found this -- lots of details of contraindications and things to consider depending on a person's disease conditions when using it.
Quinine Sulfate Capsules: Package Insert - Drugs.com
Quinine Sulfate Capsules package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.
www.drugs.com
I also found this...
Quinine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Find patient medical information for quinine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
www.webmd.com
"...This medication is used to kill the malaria parasites living inside red blood cells. In some cases, you may need to take a different medication (such as primaquine ) to kill the malaria parasites living in other body tissues. Both drugs [quinine and primaquine] may be needed for a complete cure and to prevent the return of infection (relapse)..."
And I thought primaquine was one of the chemicals in cinchona bark, but it's not.
(showing these again)
"The main plant chemicals found in quinine [cinchona] bark include: aricine, caffeic acid, cinchofulvic acid, cincholic acid, cinchonain, cinchonidine, cinchonine, cinchophyllamine, cinchotannic acid, cinchotine, conquinamine, cuscamidine, cuscamine, cusconidine, cusconine, epicatechin, javanine, paricine, proanthocyanidins, quinacimine, quinamine, quinic acid, quinicine, quinine, quininidine, quinovic acid, quinovin, and sucirubine."
Primequine's a synthetic 8-aminoquinoline derivative.
Primaquine
Primaquine | C15H21N3O | CID 4908 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov
"Primaquine is a synthetic, 8-aminoquinoline derivative with antimalarial properties... Primaquine is an aminoquinoline that has been used for the prevention and therapy of malaria for more than 50 years..."
8-Aminoquinoline - Wikipedia
en.wikipedia.org
"8-Aminoquinoline is the 8-amino derivative of quinoline."
Quinoline Alkaloids in Suspension Cultures of Cinchona ledgeriana Treated with Various Substances
Cinchona alkaloids are in extensive uses, not only for drugs but also for soft drink industries. They are harvested from the bark of trees Cinchona sp…
www.sciencedirect.com
"Cinchona bark contains quinoline alkaloids. Quinine, quinidine, cinchonine , and cinchonidine are the major substances among over thirty others (McCalley 2002)"
"The main plant chemicals found in quinine [cinchona] bark include: aricine, caffeic acid, cinchofulvic acid, cincholic acid, cinchonain, cinchonidine, cinchonine, cinchophyllamine, cinchotannic acid, cinchotine, conquinamine, cuscamidine, cuscamine, cusconidine, cusconine, epicatechin, javanine, paricine, proanthocyanidins, quinacimine, quinamine, quinic acid, quinicine, quinine, quininidine, quinovic acid, quinovin, and sucirubine."
Quinine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Find patient medical information for quinine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
www.webmd.com
"Quinine is very similar to quinidine. Do not use medications containing quinidine while using quinine."
So "very similar" meaning that in some ways the dosages of each are cumulative with each other?
Quinidine
Quinidine | C20H24N2O2 | CID 441074 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov
Quinidex (Quinidine): Side Effects, Uses, Dosage, Interactions, Warnings
Quinidex (Quinidine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
www.rxlist.com
So my point is that there are chemicals in cinchona bark that do (very similarly, worse, better?) what primaquine in combination with quinine sulphate does, because primaquine is a synthetic derivative of those chemicals in cinchona. I mean the added efficacy with malaria of primaquine's combinaton with quinine might not be very relevant for spike protein stuff, but it's an example like, similar to, the potential of the mixture of chemicals in cinchona to be more effective than one chemical being isolated from it and said to be the only "active" chemical that you want from cinchona.
But on the other hand, part two of the point, those chemicals other than quinine in cinchona might (? I don't know enough about it) need to be recognized as effectively adding to the dosage of the quinine, which could be why (it seems, from what I've read) that the traditional tribal use of cinchona bark (avoiding cinchonism symptoms) was an amount that wouldn't make a dose of quinine from it that's as much as the isolated HCQ doses for the spike protein, and that might be because of the effectively cumulative dosages of the similar chemicals adding up to be more like the isolated HCQ doses.