Both these things are true :when you say 25-50mg, are you talking about fully absorbed amount (as in DMSO topically), or are you talking about cream/gel/oral? The member TheBeard was using 25mg T in DMSO twice a day (50mg total) transscrotally, he said he felt best on this dose.
Dr. Nichols has his patients chronically using high dose T I think. He believes things like xenoestrogens are blocking the androgen receptors, so he thinks high doses are needed for men to get the most benefit today. I feel the real issue might be low 5-AR activity in most men today. TheBeard was a proponent of Dr. Nichol’s ideas.
androgen receptors are occupied by environmental xenohormones and metals of all sorts, and enzymes are underactive, both calling for high dose exogenous hormones use.