tankasnowgod
Member
- Joined
- Jan 25, 2014
- Messages
- 8,131
I can't see anything that shows test base is any safer than test with esters..
Well, the Haidut post claims that there is no benefits of esters over base test in either cost or effectiveness. He then shows that base test has no negative impact on the liver (and may actually cure many cases of cirrhosis), while synthetic versions can cause liver issues.
"As the studies towards the end of the post demonstrate, not only is free/base T orally bioavailable, but even massive doses (400mg daily) have no negative side effects on the liver and in fact accelerates the activity of several liver detox enzymes. The latter effect is highly sought-after by Big Pharma and many drugs are currently being developed/tested with the hope that such a liver-metabolism-enhancing compound will be brought to market as it has tremendous potential for treating everything from obesity, to gyno, to side effects of toxic chemotherapy. Thus, as one of the studies below directly stated, artificial/synthetic T derivatives such as 17a-methylated varieties, 19-nortestosterone derivatives (and in general any other AAS with bizarre modifications to make them less metabolizable and longer acting) have no advantages over free/base T neither due to cost nor effectiveness. In fact, unlike the readily observed liver-toxicity (including liver cancer) from various synthetic AAS, using free/base T may actually cure 60%+ of even advanced cases of liver failure (cirrhosis), as confirmed by extensive human studies several decades ago.
"So, what does that have to do with FDA’s recent T undecanoate approval? Well, according to one of the studies below, that specific T ester only works if it is dissolved in oil AND administered with a large meal containing significant amounts of fat. On the other hand, oral free/base T was absorbed without using any carriers or fatty meals. In addition, androgen esters often have unpredictable effects and in some cases may be even carcinogenic, while the free/base steroid is highly protective. It just so happens that the formulation FDA approved does NOT contain any oils as carrier/solvent and does not carry a recommendation to consume with a significant amount of fat. So, at best the formulation will be ineffective and at worst it may be carcinogenic."