I'm starting some high-dose vitamin B2 because there are studies showing a significant proportion of migraineurs getting significant improvements from high dose B2 (eg 400mg/day), with some improvement after one month and more after 3 months. I have not read any such recommendation from Peat. I know he is concerned that it is often allergenic. I'm up to day 4 at ~100mgx2/day of riboflavin powder from purebulk. I can't think of a better way to get a high dose. I haven't noticed anything particular yet, but not sure if I'm well attuned to mildly allergenic effects.
Is anyone aware of any risks from high doses of supplemental B2? Any other comment on this tactic?
Searching Peat's writing via toxinless, I found these (as well as references to it's allergenicity):
Does this mean too much time under flouorescent lighting in the past could increase requirements considerably? Or over-exposure to sun?
This one seems consistent with the possibility that once things are out of balance, the needs of particular tissues could be much higher than normal.
Is anyone aware of any risks from high doses of supplemental B2? Any other comment on this tactic?
Searching Peat's writing via toxinless, I found these (as well as references to it's allergenicity):
http://raypeat.com/articles/articles/ro ... ging.shtmlRay Peat said:Riboflavin, vitamin B2, is an essential component of the mitochondrial respiratory enzymes, and it is very easily destroyed by light (blue light and especially ultraviolet). When it is excited by high energy light, it can spread the damage to other components of the mitochondria, including the cytochromes and the polyunsaturated fatty acids. The other B vitamins are affected when riboflavin's actions are disturbed.
Does this mean too much time under flouorescent lighting in the past could increase requirements considerably? Or over-exposure to sun?
http://raypeat.com/articles/articles/ge ... tion.shtmlRay Peat said:However, there is a famous experiment in which rats were made deficient in riboflavin, and when their corneal tissue showed evidence of the vitamin deficiency, they were given a standard diet. However, the standard diet no longer met the needs of their eye tissue, and during the remainder of the observation period, only a dose of riboflavin several times higher than normal would prevent the signs of deficiency. A developmental change had taken place in the cornea, making its vitamin B2 requirement abnormally high.
This one seems consistent with the possibility that once things are out of balance, the needs of particular tissues could be much higher than normal.