High Dose Vitamin E Supplements Antagonize Vitamin K

Discussion in 'K' started by Gabriel, Aug 6, 2013.

  1. Gabriel

    Gabriel Member

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    These studies indicate that overdosing on Vitamin E antagonizes Vitamin K by reducing its tissue levels. The reduction appears to be partly related to the phenomenon thatg Vitamin E and K share similar transporters/metabolizing enzymes. When high dose Vitamin E is given it may block the transporters/enzymes that are needed to integrate Vitamin K into the appropriate tissues.

    So similar to Aspirin, one should consider supplementing Vitamin K when trying high dose Vitamin E. Otherwise he may risk Vitamin K deficiency which can cause downstream problems. This effects also appears to affect natural and not only synthetic vitamin E as seen in the study by Booth et al who used natural RRR alpha-tocopherol (fourth reference).

    Randomized controlled trials on Vitamin E indicate that this effect may affect overall mortality. In these trials only lower-dose Vitamin E supplementation (<400IE/day) had beneficial effects on mortality, while no beneficial effect and partly deleterious effects were found for high dose Vitamin E supplements (>400IE/day). There are no trials that studied a combination of Vitamin E with Vitamin K.

    Some people mentioned side effects when trying high dose Vitamin E. I wonder whether those side effects are also related to its direct Vitamin K antagonizing effect.

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    Coagulopathy Associated With Vitamin E Ingestion
    http://www.ncbi.nlm.nih.gov/pubmed/4479598

    Thirteen-week toxicity study of d-alpha-tocopheryl acetate (vitamin E) in Fischer 344 rats.
    http://www.ncbi.nlm.nih.gov/pubmed/3804111


    Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544331/

    Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status.

    http://www.ncbi.nlm.nih.gov/pubmed/15213041

    Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4.
    http://www.ncbi.nlm.nih.gov/pubmed/11276919

    Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.
    http://www.ncbi.nlm.nih.gov/pubmed/7867999

    Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks.
    http://www.ncbi.nlm.nih.gov/pubmed/9285253

    Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.

    http://www.ncbi.nlm.nih.gov/pubmed/22707266
     
  2. Bluebell

    Bluebell Member

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    Thanks a lot, I'd kind of heard of that, but had not given it enough importance.

    I'll definitely look into starting up K supplementation again. Of course, I get some issues with that too, but hopefully it'll all balance out ;)
     
  3. j.

    j. Guest

  4. aaron_c

    aaron_c New Member

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    Hi Yall,

    Thank you for the articles! Very interesting reading. Maybe the shared enzymes, I believe to cleave the side-chain(?) would account for why the few people I have read who tried taking higher doses of MK-7 had adverse reactions, whereas high doses of MK-4 seem relatively benign.

    I am currently taking 42 mg of MK4 per day, and I also wonder if high doses of MK-4 would deplete or interfere with vitamin E? For the record, I am guessing it does not, or if it does, the effects would be minimal...but it is just a guess. Does anyone have any insight?
     
  5. tara

    tara Member

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    Welcome aaron-c :welcome
     
  6. Newbophyte

    Newbophyte Member

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    I'm taking 400 IU of vitamin E, but notice that my K levels are quite low. Maybe this should be done intermittently in light of this news.
     
  7. forterpride

    forterpride Member

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    @haidut So is there a ratio we should be shooting for? Haiduts estroban is 100iu of E for every 2 mg k2...so if you were taking 400iu of E would 8mg K2 balance appropriately or am I missing something?
     
  8. allblues

    allblues Member

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    I just found this study Excess α-tocopherol decreases extrahepatic phylloquinone in phylloquinone-fed rats but not menaquinone-4 in menaquinone-4-fed rats. - PubMed - NCBI

    In this study, it appears that alpha-tocopherol didn't affect MK4 levels when rats were supplemented with MK4.
    α-tocopherol did however lower phylloquinone (K1) levels, as seen in the OP studies.

    Could it be that α-tocopherol mainly lowers K1, thus depleting substrate for K2 production, leading to the observed lower K1 and K2 levels, when rats are fed only K1?

    Maybe vitamin E then isn't such a big threat to vitamin K status for those of us supplementing K2, which i guess would be most of us here.

    Also, interesting snippet about gamma-tocopherol not lowering extrahepatic K1 like alpha-tocopherol;
     
  9. Frankdee20

    Frankdee20 Member

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    Damn man, how is one supposed to properly balance this all out ? I take D and K separately from E and A, separate days too.
     
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