High Dose Vitamin E Supplements Antagonize Vitamin K

Gabriel

Member
Joined
May 7, 2013
Messages
229
These studies indicate that overdosing on Vitamin E antagonizes Vitamin K by reducing its tissue levels. The reduction appears to be partly related to the phenomenon thatg Vitamin E and K share similar transporters/metabolizing enzymes. When high dose Vitamin E is given it may block the transporters/enzymes that are needed to integrate Vitamin K into the appropriate tissues.

So similar to Aspirin, one should consider supplementing Vitamin K when trying high dose Vitamin E. Otherwise he may risk Vitamin K deficiency which can cause downstream problems. This effects also appears to affect natural and not only synthetic vitamin E as seen in the study by Booth et al who used natural RRR alpha-tocopherol (fourth reference).

Randomized controlled trials on Vitamin E indicate that this effect may affect overall mortality. In these trials only lower-dose Vitamin E supplementation (<400IE/day) had beneficial effects on mortality, while no beneficial effect and partly deleterious effects were found for high dose Vitamin E supplements (>400IE/day). There are no trials that studied a combination of Vitamin E with Vitamin K.

Some people mentioned side effects when trying high dose Vitamin E. I wonder whether those side effects are also related to its direct Vitamin K antagonizing effect.

_____________________________

Coagulopathy Associated With Vitamin E Ingestion
http://www.ncbi.nlm.nih.gov/pubmed/4479598

Thirteen-week toxicity study of d-alpha-tocopheryl acetate (vitamin E) in Fischer 344 rats.
http://www.ncbi.nlm.nih.gov/pubmed/3804111


Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544331/

Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status.

http://www.ncbi.nlm.nih.gov/pubmed/15213041

Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4.
http://www.ncbi.nlm.nih.gov/pubmed/11276919

Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.
http://www.ncbi.nlm.nih.gov/pubmed/7867999

Interaction of vitamins E and K: effect of high dietary vitamin E on phylloquinone activity in chicks.
http://www.ncbi.nlm.nih.gov/pubmed/9285253

Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.

http://www.ncbi.nlm.nih.gov/pubmed/22707266
 

Bluebell

Member
Joined
May 24, 2013
Messages
437
Thanks a lot, I'd kind of heard of that, but had not given it enough importance.

I'll definitely look into starting up K supplementation again. Of course, I get some issues with that too, but hopefully it'll all balance out ;)
 

aaron_c

New Member
Joined
Dec 12, 2014
Messages
1
Hi Yall,

Thank you for the articles! Very interesting reading. Maybe the shared enzymes, I believe to cleave the side-chain(?) would account for why the few people I have read who tried taking higher doses of MK-7 had adverse reactions, whereas high doses of MK-4 seem relatively benign.

I am currently taking 42 mg of MK4 per day, and I also wonder if high doses of MK-4 would deplete or interfere with vitamin E? For the record, I am guessing it does not, or if it does, the effects would be minimal...but it is just a guess. Does anyone have any insight?
 

tara

Member
Joined
Mar 29, 2014
Messages
10,273
Welcome aaron-c :welcome
 

Newbophyte

Member
Joined
Nov 11, 2014
Messages
37
I'm taking 400 IU of vitamin E, but notice that my K levels are quite low. Maybe this should be done intermittently in light of this news.
 

forterpride

Member
Joined
Jun 7, 2013
Messages
160
@haidut So is there a ratio we should be shooting for? Haiduts estroban is 100iu of E for every 2 mg k2...so if you were taking 400iu of E would 8mg K2 balance appropriately or am I missing something?
 

allblues

Member
Joined
Oct 30, 2015
Messages
221
I just found this study Excess α-tocopherol decreases extrahepatic phylloquinone in phylloquinone-fed rats but not menaquinone-4 in menaquinone-4-fed rats. - PubMed - NCBI

In this study, it appears that alpha-tocopherol didn't affect MK4 levels when rats were supplemented with MK4.
α-tocopherol did however lower phylloquinone (K1) levels, as seen in the OP studies.

After PK administration, α-tocopherol was observed to decrease PK in kidney, adrenal gland, lung, testis, and brain but not in serum and liver, whereas, after MK-4 administration, α-tocopherol did not affect MK-4 in serum and tissues.

Could it be that α-tocopherol mainly lowers K1, thus depleting substrate for K2 production, leading to the observed lower K1 and K2 levels, when rats are fed only K1?

Maybe vitamin E then isn't such a big threat to vitamin K status for those of us supplementing K2, which i guess would be most of us here.

Also, interesting snippet about gamma-tocopherol not lowering extrahepatic K1 like alpha-tocopherol;
Initially, the dietary effect of RRR-α-tocopherol, but not RRR-γ-tocopherol, in decreasing extrahepatic PK concentrations was confirmed.
 

Frankdee20

Member
Joined
Jul 13, 2017
Messages
3,187
Location
Sun Coast, USA
Damn man, how is one supposed to properly balance this all out ? I take D and K separately from E and A, separate days too.
 
Similar threads
Thread starter Title Forum Replies Date
Mito The Importance And Safety Of High-Dose Vitamin D3 D 9
Mito Effect Of High-Dose Vitamin D Supplementation On Volumetric Bone Density And Bone Strength D 1
A What Is The Problem With High Dose Vitamin E Supplementation? E 11
A Does High Dose Vitamin C Increase The Body's Requirements For Magnesium (or Sodium) ? Supplements, Pharmaceutical Drugs 18
A.R Is 5mg Vitamin D IM Injection Too High Of A Dose? Ask For Help or Advice 8
A Could High Dose Vitamin K2 Stop Absorption Of Other Fat Solubles? Or Other Problems? K 9
haidut High-dose Vitamin C Is Making A Comeback As A Treatment For Cancer Scientific Studies 63
A High Dose Of Vitamin B6? Ray Peat Topics 4
F Anyone Tried Camu Powder For High Dose Vitamin C? Supplements, Pharmaceutical Drugs 2
T High Dose Vitamin D3 Daily (100,00iu) Supplements, Pharmaceutical Drugs 45
haidut High-dose Vitamin C Or Niacinamide May Treat Advanced Colon Cancer Scientific Studies 12
Renaiscience_Man High Dose Aspirin And Vitamin K2 May Be The Key To Eradicate ''incurable'' Bacterial Infections Whic Scientific Studies 15
L High-dose Vitamin K2 Supplementation K 28
N Do you need extra calcium with high dose k2? K 14
youngsinatra High Dose Niacinamide Self-Experiment. Experiments 20
Mito Effect Of High-Dose Omega-3 On Major Adverse Cardiovascular Events Polyunsaturated Fats, Seed Oils 0
maillol UK High Dose K2 MK4 Supplements, Pharmaceutical Drugs 3
ddjd High Dose Taurine Definitely Effective Against MPB Ask For Help or Advice 17
HealthisWealth The Manila Doctors Hospital Is The First In The World To Try High-dose Melatonin (36 Mg To 72 Mg/day Supplements, Pharmaceutical Drugs 0
haidut Low-dose (but Not High) Niacinamide Reverses Reproductive Decline In Old Females Scientific Studies 3
Jib High-Dose Glycine For OCD And BDD Scientific Studies 4
boris High Dose Cyproheptadine Cyproheptadine 6
ddjd Anyone Experiment With High Dose Taurine? Ask For Help or Advice 104
Ficini High Dose Taurine To Reverse Tinnitus Eyes, Ears, Nose and Headaches/Migraines 33
Mito Metabolic Effects Of A Prolonged, Very-high-dose Dietary Fructose Challenge In Healthy Subjects Scientific Studies 11
ddjd Solved Dandruff Problem With High Dose K2 MK4 Ask For Help or Advice 5
E Issues After Taking High Dose Niacinamide Supplements, Pharmaceutical Drugs 17
Peatogenic High Dose Androsterone Supplements 9
olive Iron Deficiency Anemia Due To High-dose Turmeric Scientific Studies 21
ImprovingDaily Have Any Of You Tried Exemestane With High Dose DHEA Or Anything Similar? What Were Your Results? Supplements, Pharmaceutical Drugs 6
Infarouge High Dose Iodine (grams) Supplements, Pharmaceutical Drugs 26
Hans High Dose Methylene Blue Experiment Experiments 122
F High Dose Progesterone Increasing My Insulin Resistance? Female Issues 49
burtlancast High Dose Niacin (6g/day) Reduces Hypercholesterolemia By 20% Or More Scientific Studies 1
Arrade High Dose Mk4 Hairloss Hair & Nails 59
H High-dose Proline For Sleep? Amino Acids 3
S High Dose Vit E Every Day. Is Cycling Required? E 3
biggirlkisss High Dose Apsirin Wtih K2 For Back And Shoudler Pain Ask For Help or Advice 0
B Oregano High Dose When Breast Feeding? Female Issues 5
biggirlkisss Why Do Antihistimes Are High Enough Dose Increase Serotonin Ask For Help or Advice 7
K Why Can't I High Dose Progesterone? Female Issues 14
gilson dantas Progesteone High Dose And Prolactine . Raising Supplements, Pharmaceutical Drugs 41
S Using High-dose Pregnenolone As An Anti-depressant Experiments 67
ecstatichamster High Dose Thiamine For Focus, Clarity, Reasoning, Cognitive Ability Experiments 24
Insomnia High Dose K2 And Protocol! Supplements, Pharmaceutical Drugs 23
haidut Low-dose Aspirin Reduces Miscarriage Risk In Women With High Inflammation Scientific Studies 4
LukeL High Dose Niacinamide Relieves My Scalp Itch Ask For Help or Advice 18
Dan Wich High-dose Methylene Blue For Treating Manic-depressive Psychosis Scientific Studies 6
Mr Rossi Studies: High-dose Thiamine Improves Fibromyalgia & Fatigue Symptoms + Own Experiment! Logs 64
A High Dose Of Caffeine-sluggish, Constipation, Weakness, Exhaustion Supplements, Pharmaceutical Drugs 38

Similar threads

Top