Haidut Email Advice Depository

[raypeatclips]

Heart has testosterone and other protective steroids. The heart is the muscle that is absolutely crucial to protect from succumbing to wasting under stress, so the protective anti-cortisol steroids gather there and stay in higher amounts even if the rest of the skeletal muscle wastes away when under stress or sick. I think tongue is also a good source of steroids, but I am blanking on exactly which ones.
Also, as the post above says, the heart has a lot of quinones and especially CoQ10, as well as vitamin E and possibly K.

Perfect, thank you, that is exactly what I was intrigued about.

Heart's also one of the least offensive organ meats. The flavor's much like steak, similar to tongue, or so I hear. I used to eat a few servings of raw beef heart daily in high school, and I preferred it much to raw kidney.

Good to hear! I ate liver for long enough until I managed to make it taste less offensive and put up with it. Nice to know I won't have to do similar with heart.

 

[Braveheart]

Grew up eating tongue, heart, brain, long ago...tongue a delicacy here in Belize. Try heart in slow cooker.

 

[Wagner83]

What about eating dic.k? Nutrients+protective compounds.

 

[jb116]

I can enjoy kidneys and tongue from time to time, and I've eaten brain, but I've not got a method I'm familiar with for cooking heart - got any nice easy tasty recipes or tips you want to point to?

tara I'd ground it up with regular grass-fed ground beef and then add some spices, etc. Pretty damn good

 

[Broken man]

Hello, I was finding more info about caffeine and I want to ask you when you wrote that you take caffeine

Each capsule is 200mg and I take 3 capsules 6 - 9 times daily.

And that

I take caffeine away from big protein meals. Usually, 2-3 hours away from meals is enough to not get ammonia issues, at least for me.

Did you use something to counter ammonia like biotin or zinc or how you did it when you was taking caffeine pills so many times? It is imposible to take it 2 hours away from protein meals when somebody is taking caffeine 6 times a day. Thank you.

 

[tara]

tara I'd ground it up with regular grass-fed ground beef and then add some spices, etc. Pretty damn good

Thanks jb. I guess in the absence of a grinder just chopping it fine and adding it in with mince or other stew could work then.

 

[Such_Saturation]

People don't eat like Peat enough so they should take more supplements?

 

[tara]

What about eating dic.k? Nutrients+protective compounds.

I gather mountain oysters are considered a delicacy by those who have acquired the taste.

 

[Wagner83]

I gather mountain oysters are considered a delicacy by those who have acquired the taste.

Rocky Mountain oysters - Wikipedia
"This delicacy is most often served as an appetizer.[1]"

Testicle festival - Wikipedia
"A testicle festival is an event held at several small towns in which the featured activity is the consumption of animal testicles, usually battered and fried.
[...]
Every year in September the villages of Ozrem and Lunjevica in the municipality of Gornji Milanovac, Serbia, hosts the World Testicle Cooking Championship.[8][9] The festival serves up a variety of testicles, including wildlife. It also gives awards for "ballsy" news makers. U.S. President Barack Obama and pilot Chesley Sullenberger won awards in 2010
"
Haidut had a good point on the Balkans and the art of cooking organs. One of the reasons Serbia has so many strong, virile and tall men may be due to regularly eating testicles from generation to generation. @nikolabeacon

 

[Wagner83]

So far it has been a total failure but there's this thread if people want to discuss the mails posted in this one Haidut Mails Discussion/comments Thread . Things become a mess quick otherwise.

 

[theLaw]

Not sure if people are aware, but Danny is hosting Georgi this Friday the 12th on this Patreon live chat.

"Dear Patrons,

Join me and my special guest Georgi Dinkov (aka: Haidut) on Friday January 12th at 6PM (PST) for the exclusive hour-long $1 and up Patron live stream. "

Here's Danny's patron if you're interested:

www.patreon.com/dannyroddy

Personally, I think that Danny's material is well worth supporting.

 

[Dobbler]

Not sure if people are aware, but Danny is hosting Georgi this Friday the 12th on this Patreon live chat.

"Dear Patrons,

Join me and my special guest Georgi Dinkov (aka: Haidut) on Friday January 12th at 6PM (PST) for the exclusive hour-long $1 and up Patron live stream. "

Here's Danny's patron if you're interested:

www.patreon.com/dannyroddy

Personally, I think that Danny's material is well worth supporting.

Ive never used patreon but how much u have to pay to watch all previous podcasts and articles he has written?

 

[Wagner83]

About diet and haidut's disagreements with Peat:
Wagner83: Hey, happy new year! [not 2018]

I've been listening to an awful lot of podcasts from Ray and find it hard to stay critical of his claims and ideas since most of them make a lot of sense. Are there topics you disagree with Ray on?
I have some doubts about the starch persorption potential issues, the idea that consuming large amounts of commercial milk daily is fine . I'm also not sure about his ideas on fat, whether we should limit all PUFAS and therefore fat, or if the ratio is what matters most.

I know you don't consume commercial milk , starch and so to reach the right amount of calories you eat things like cheesecake, chocolate and ice cream which are all high in fat. Is your diet high in both fat and sugar ?

-------------

Non related but some good thoughts about high dht in here Area-1255: [Area-1255] The High DHT/Low Estrogen PhenoType
I find the high adrenaline part interesting, on sorghum I feel a lot of the higher dht lad symptoms within a matter of days.

haidut:
I never felt well on commercial milk. Ironically, I do better on milk protein shakes, which is what I drink to supplement my protein. When I manage to get some farm milk the results are very different. Same with eggs, meat, fish, etc which makes me think most commercial food (even organic one) is junk. Most of the protein I get from food like cheese, eggs, some meat and shellfish, and some liver. I add some gelatin powder when I remember to do it. My diet is probably equal in terms of fat/protein/sugar as percentage of daily calories (33/33/33). Recently, I found that I don't need as much protein if I eat enough sugar, which is what Ray has said as well. Sugar spare protein and if insulin sensitivity is good a person can probably get by on even 50g protein daily provided he consumes at least 100 sugar daily.
The starch can be good source of carbs but it depends on the person's GI health. Some starches like bread and rice definitely give me endotoxin symptoms but potatoes seem to be fine. As far as PUFA, what matters is the ratio of PUFA to saturated fat in blood. A person can have very high PUFA in adipose tissue but if lipolysis is low then that PUFA is not doing much damage. Still, it is better to have low PUFA in stores as under stress it is bound to be released and do some damage. So, if a person is relatively lean then eating some PUFA in a meal is probably OK if it is balanced by a good deal of saturated fat. But an older or more overweight person should limit PUFA consumption as much as possible as the body preferentially stores PUFA and thus contributes more to overall toxic load. PUFA is a direct thyroid "receptor" antagonist so any release in the blood lowers metabolism, not to mention its estrogenic and inflammatory effects.
So, for a healthy person the goal should be more to avoid PUFA dominance. But for an older or obese person the goal should really be to become as PUFA depleted as possible.
Some of the things don't always agree with Peat on are his statement that pregnenolone can be find in any dose and that it does not have any anti-androgenic effects. That I find to be not true both based on evidence and reports from people on the forum. I think pregnenolone works best when used in doses of 30mg - 50mg daily, especially when combined with low dose DHEA and progesterone. I think thyroid supplementation can be hit or miss for many people so insisting that thyroid is more or less THE supplement to always consider is probably not going to work for many people. We are overloaded with endocrine disruptors from the environment and I would like to see Peat say something about that in his newsletters/interviews and how we can get rid of those substances. The BPA and other estrogenic, anti-thyroid chemicals are especially bad and so far I have not been able to find definitive answer as to what can remove them from tissues. Have not seen Peat say much about reversing that damage or avoiding storage of these chemicals to start with and I think in a person with endocrine disrupors overload many of the pro-thyroid substances may not work despite their best efforts.
Anyways, my main disagreement with Peat is the insistence of specific foods as always being good when it is clear that quite a few people do not respond well to commercial milk, orange juice, or even gelatin. But Peat often writes from personal experience and not so much based on large-scale studies, so I can't blame him for that. Ultimately, his guidelines are on the proper direction and not on the specific right path for everyone. The specific right path is unique to every person but I agree that the direction is always better metabolism.

 

[Wagner83]

About diet: fructose, glucose, starch and proteins.
Wagner83:
Not sure if you remember that issue we discussed , I thought I was doing great starch free and sucrose+ fruit juices+decent fat and proteins full but at some point I got plenty of issues, very uncomfortable sensations in the back , middle of chest, radiated in the right arm and to the top of the head, it increased in intensity and duration over time and came on after meals. Well dropping the sucrose and milk , returning to starch resolved the issue. Fructose was the culprit as apple juice (or other juices) still leads to problems if I take too much.

haidut:
I still think that the sucrose and fructose, as well as some acids in fruit juices (malic and citric) can chelate minerals if eaten in big amounts. So, the mineral intake should increase to compensate for the higher intake of "chelators" like that. Not sure what food has enough minerals and how much should be eaten to compensate for the increased chelation, but I doubt the sucrose or fructose have some kind of intrinsic detrimental effects.

Wagner83:
I don't know but I can only report my experience which was unfortunately pretty terrible, I wish it was not ! An other forum member (eire24) reported similar issues and a female member experienced acute pancreatitis on a fruit diet (but then she probably did not get enough proteins).
The only positive explanation I had was a reactivated gallbladder (androgens?) which meant gallstones started to get moving/stuck when before they weren't. I had pale stools and slightly high bilirubins too, so bile / liver/gallbladder could have been involved in some ways. Yet as of late I have not been doing too bad and have not noticed the issue, except that I get too much fat with my proteins (goat milk, cheese, eggs) and still don't get enough of them.

The minerals chelating stuff is interesting, nikolabeacon suggested it was one of the problems of high sucrose/fructose.

haidut:
The fruit only diet is risky as we don't know how much protein fruit can provide if it is the only food eaten. I would not recommend doing it. What do you thin is in starch that would make it different from sucrose/fructose and fruit juice? What could possibly be in starch that allows people to eat a ton of it but sucrose/fructose causes problems? Maybe it is indeed the protein, which most starches have. So, Ray's meals of steak and Coke or fish and marmalade could address that issues and still avoid the starch. Not saying we should not eat any starch, I just want to know what is it in starch that avoids the problems of sucrose/fructose from fruits or juice.

Wagner83:
Well starch has no fructose and takes a different timeframe to be digested (for the better or worse?), so there are some differences, when I got my issues I was getting a decent amount of proteins, hell even if I drink plenty of apple juice/orangina/sucrose now I get similar issues. My digestion of rice and potatoes seems to have improved as I ate them more often and with enough proteins. Tyw seems to be right in that when one eats and when one sleeps/wakes up is really important. A big meal with plenty of carbs/starch too late in the morning (noon) or in the afternoon and I die, food coma. However in the morning and evening it seems fine. There's the potential issue of sugar in liquid form vs solid, it is one thing researchers seem to be investigating, also not sure what the importance of a decent insulin release is to pocess glucose , carbs, or even for androgens etc..
What I'm curious about (and I did not see anyone mention it) is why starch (rice in particular since there are no minerals) would be better than glucose syrup or glucose powder? Again there's a difference in the form (powder/syrup vs solid food that requires some work to be digested) , but glucose refills muscle glycogen very efficiently so for anyone and athletes in particular easily digestible glucose should be very welcome. Fructose did not seem to perform as well, on the other hand it seems to work differently for the liver.
Afaik starch (wheat, potatoes etc..) also has a decent amount of minerals, in particular I think about magnesium which is hard to find.

Do you think the proteins in starch (potatoes aside) has any value? I admit I never counted them, apart from lentils (not really starch ) and buckwheat I thought they were pretty useless.

haidut:
Glucose powder and syrup would be great as food. I have tried them but I get a "food coma", which I do not get if mix the glucose with some coconut oil or if I use sucrose. You can buy the syrup in most stores in Europe, and they also usually sell fructose powder so you can try experimenting with different ratios of glucose/fructose. Maybe it is just that 50% fructose is too much, and lower ratios around 30% fructose (70% glucose) would alleviate the problem.
As far as proteins in the starch - there is some value but since most grains and legumes do not offer complete protein with all essential amino acids, the protein is considered of low value and does not stimulate protein synthesis (MPS) as that has been shown to depend on presence of all EAA at the same time and beyond a certain concentration. But I think the reason protein like meat and cheese go well with starch is that the incomplete protein in starch adds some additional amino acids to the protein in cheese and meat and make stimulate more MPS than the meat/cheese would do on their own. I have seen only one or two studies that have hinted at this effect so can't say for sure, but if it starch makes you feel better then I'd eat it unless it gives you constipation or IBS symptoms, which would be indication that it is raising endotoxin/NO/serotonin.

 

[Wagner83]

About acid/base balance, fasting, metabolic types etc..

Wagner83:What do you think about gbolduev? I remember you discussed with him quite a bit at some point. I'm not interested in the particular case of finasteride but more about his ideas on receptors, minerals, serotonin/adrenaline balance etc.. Post Finasteride Syndrome, 5ar, And The Brain

haidut:
I think some of his ideas on mineral balance are solid as they are used clinically. But he changes his theory quite a bit and seems so fanatically convinced he is right every time, only to back off later. Back in 2014 we exchanged some skype messages about protein and he was dead certain egg whites were the only protein with positive nitrogen balance (NNU). Subsequently, I confirmed that not to be true through direct tests. He was saying any protein other than egg whites would raise ammonia and would be detrimental to health but I found that to be simply a consequence of low metabolism and catabolic state with high serotonin/estrogen/cortisol, which increase with aging too and it is not a coincidence that old people have trouble with protein consumption. However, as one study showed, simply adding glycine restored the anabolic response to protein in old animals. So, egg whites have nothing special about them.
I think he generally cares about what he says but in my experience these are just patch fixes. People have tried them and came back to me in worse shape. He himself keeps saying he will never post again on this forum yet he keeps reading the material here and every once in a while starts a discussion that gets out of control. Why be here when you disagree so much with Peat? I suspect he agrees with a lot of what Peat has to say but wants to prove his approach is better. Unfortunately, I never saw anybody get systemically better by ingesting various ratios of minerals or doing month-long fasts, or chelating like a madman. The body can adapt to anything, including such extreme measures, and the adaptation is not pretty. The downregulation of metabolism from month-long fasts is hard to reverse.
[...]
IMO, the "metabolic types" he is describing are nothing but the most common maldapted states for people who have been under stress for too long. Does not mean we have to continue supporting them in that state. If everybody was a different metabolic type why is it that mortality is lowest at age 11-12, just before puberty, when metabolism/CO2 is highest and iron/copper ratio at its lowest? If everybody is different then we should be peaking at different ages, right?
Anyways, in my case it happened just like Peat said and the studies I saw predicted. Fasting, and thus fatty acid oxidation, raised my cortisol, estrogen, prolactin and serotonin as well as my TSH. My T, DHEA and DHT dropped. How can estrogen be good and left unopposed when everybody with extra adipose tissue on their belly (which is pretty much everybody over 25 these days and even kids have it) produces a ton of estrogen? The old name of estrogen was "adipin" because it was involved in fat synthesis, oxidation, and lipolysis so much. Every time somebody is under stress, estrogen rises to help switch from sugar to fat oxidation. I did take thyroid at that time and TSH dropped back to normal, but it was niacinamide in higher doses that saved me from metabolic acidosis. My anion gap rose to 18-20 every time I tried to fast.
Anyways, it think it may prove useful in the long run that gbolduev posted all of these things. Life is about experimentation and I can't wait to see all of these beaming, healthy people with full heads of hair and normalized metabolism. I am serious, Peatarian lifestyle was long overdue for a battle test and I think all of these people fasting and putting lecithin on their heads will be the testers.
As far as niacinamide - it may be a good thing that you feel less benefit. It would mean your NAD/NADH ratio is good now and lipolysis is under control. The more benefit you feel from niacinamide the worse your health is. So, maybe you can keep taking the 100mg as a long term longevity benefit.

Wagner83:
That could be true it would mean quite a few people have deranged metabolic state early on. It's still pretty compatible with "his" theory and desire to have slow oxidizers move on to a faster oxidizer state while people whose metabolism is very high could use a brake (nutrients requirements etc..). I don't think he wants everyone to be kept in his own box, it could be he said contradictory things on the matter though.
Fasting sounds like it was health galore for you. If people do get great hair growth I wonder if it means stress can lead to hair growth as a defensive mechanisms, as estrogens can lead to some of the excessive growth of hair in the nose , ears etc...
As far as I am concerned the "peat diet" is terrible and does not work for most people (milk + OJ).

haidut:
Peat said in a few of his interviews that if the person is one of the few who can endure fasting well and thus lose excess fat their hormonal profile changes drastically for the better. One of the things that happens is estrogen and cortisol go down as a baseline. This is not some study, it is why doctors advise people to lose weight. Unfortunately, fasting is the wrong approach for most people. Peat recognizes that and tries to suggest ways for compromised people to lose weight - control lipolysis and eat less fat and more protein/carbs. But on the milk I agree - for a person in bad health it does not seem to be the best recourse. The OJ is probably fine, and in fact if I were to fast I would use OJ only for a few days as the electrolytes in it help limit muscle loss due to cortisol.
Btw, the chronic decline of DHEA with aging is also due to chronically elevated estrogen in adipose tissue. So, yet another reason not to let it rule unopposed.
Circulating dehydroepiandrosterone-sulphate decreases even with a slight change in oestradiol. - PubMed - NCBI
"...In conclusion, circulating DHEA-S decreases even with a slight increase in oestradiol level. Impact statement What is already known on this subject: A transient increase in DHEA-S in women during the menopausal transition may be involved in the occurrence of menopausal symptoms and/or unfavourable metabolic changes. Hormone replacement therapy decreases circulating DHEA-S level. However, dose dependency of the change in DHEA-S on oestrogen has not been reported. What the results of this study add: Circulating DHEA-S decreases even with a slight increase in oestradiol level. What the implications are of these findings for clinical practice and/or further research: Adrenal function may respond to a small change in oestrogen."

Finally, the acid-base balance gbolduev talks about is controlled by the endocrine system and especially thyroid.
Endocrine Control of Acid-Base Balance - Comprehensive Physiology - Alpern - Wiley Online Library

So, he may very well be trying to achieve the same thing Peat is but with drastically different approach, which also seems to be further down the cascade. The redox balance (and thus thyroid/metabolism) precedes the acid/base balance. The latter depends on the former even though they do form a feedback loop. If he was not so opposed to Peat I think we could have had a very productive discussion here. The RU486 drug was recommended by Peat long ago (search his website) and he has written about it in his articles. The drug is anabolic, with anti-cortisol and anti-estrogen effects. So, quite in line with "preventing tissue destruction" as Peat wrote. Anything anti-cortisol will be highly trophic for the brain, so people with PSSD and PFS (both of which have high cortisol as both SSRI and finasteride raise cortisol) are of course expected to benefit. To promote this drug and oppose Peat is a contradiction.

 

[Wagner83]

About Eck and Wilson, ph, contrarian endocrinology etc..

Wagner83:
What are your views on contrarian endocrinology, or using the rebound effect of compounds to get better long term? Quite a few (most?) of those who have tried RU are doing better, not sure this necessarily means contrarian endocrinology is at work here but I'm curious.

haidut:
As far as the contrarian endocrinology - there is nothing contrarian about it. Gbolduev says to antagonize receptors (GR, PR, AR, and ER) in order to increase their density/sensitivity, so that when RU486 is stopped the organism will raise steroid production to compensate. There is a bit of a problem with that but let's assume it works as intended. The exact same thing can be achieved by lowering levels of specific steroids like cortisol and estrogen as the lower levels will also upregulate receptor sensitivity and/or their density. So, two different ways to achieve the exact same thing. Golduev says not to lower any of these steroids because they are needed to keep things like potassium or sodium in balance. But antagonizing the receptors has the same unbalancing effects as to the cell it does not matter if you lowers levels of a steroid so less of it enters the cell or if you use an antagonist so it reduces the effects of the steroid even though its levels are normal (or high). So, either both approaches work or both do not work. They are the same thing as far as the effects on the cell are concerned.
Now, about the small problem I mentioned above. Let' say you choose to go the RU486 way and antagonize the receptors and increase sensitivity. When you are done, you stop the drug and wait for the rebound. That rebound will only come if thyroid is working well because production of steroids requires ATP and high NAD/NADH ratio at EVERY step of the way. Starting with the first step where StAR gets cholesterol into the mitochondria, through the side cleavage enzyme that generates pregnenolone and all the way down to things like DHT and androsterone - all of these steps require energy. RU486 does nothing to restore that energetic "balance" if there was an issue beforehand. So, good approach with the receptor rebound theory but certainly not any different from what Peat is saying (just another equivalent approach) and does not address metabolic disturbances. Gbolduev think that by forcing potassium into the cell metabolism will be restored but on that part I disagree with him. No need to force potassium into the cell, it already has a preference for being there. More often the issue is low magnesium, without which PDH/PDC cannot work and ATP cannot be produced and without ATP no magnesium can be retained. So, supplementing with magnesium will probably not solve the deficiency unless ATP is available and for that thyroid is needed, or another substance that can increase ATP like maybe methylene blue or progesterone. But thyroid is still the best way to retain magnesium.
There are a number of other major issues that the receptor sensitization approach does not address. Namely, endotoxin, inflammation, endocrine disruptors, PUFA storage, insulin resistance fro excessive lipolysis, etc. Each one of these can easily derail the whole idea of receptor desensitization and so far I have not see a proposal on what to do about those. Endotoxin is probably at the core of all of most metabolic derangements and any solid holistic theory of health and its restoration should include dealing with endotoxin somehow. So, my guess is the next thing we will see gdolduev propose is some sort of TLR4 antagonist
As far as the people in PFS feeling better - I am sure some will, but for most it will be temporary. Like I said, the receptor sensitization is a valid approach. However, most of them suffer from cognitive dissonance. The drug RU486 is an estrogen antagonist, so for them to claim that lowering estrogen makes things worse while at the same time they are taking an estrogen antagonist is a bit hypocritical. Be that as it may, the positive effects will probably be short lived and if anybody gets truly cured of PFS it will probably be less than 1% of those people. Finasteride does a lot more than derange hormones, it damages nerves as I mentioned in the other thread and also seems to damage liver and intestinal function. We don't yet know by what mechanism but if those issues are there then the receptor sensitization won't do much for most people. It will probably work for those who used finasteride briefly and that's it. So, give it another 1-2 weeks and let's see how many of those people are still on the forum asking question of claiming they were "cured". I bet most of them will still be here.

Wagner83:
I think one of his points is that he is ok with using drugs for the short term (like RU) -this is against a lot of what I see here (supplementing some androsterone, thyroid, niacinamide, vit E, b vitamins, prog, preg etc..) - and with very specific context, I mean the individual's context, same thing he said for the uselessness of most studies:
Man Goes Anti-Peat And Demonstrates Results From 20's To Mid 40
Announcement - Regarding The Recent @gbolduev Threads
Man Goes Anti-Peat And Demonstrates Results From 20's To Mid 40

Here is what he has to say about endotoxin if you manage to read through the LOLz and arrogance galore:
Post Finasteride Syndrome, 5ar, And The Brain
Post Finasteride Syndrome, 5ar, And The Brain

Btw he said a few times that androsterone would decrease 5ar / dht .
Post Finasteride Syndrome, 5ar, And The Brain
"If you dont understand that androsterone inhibits 5AR. I cant' help you further more."

haidut:
I am sorry but some of what he says is just crazy. Like this for example:
"...But if you control the bacteria you wont have any of these issues. And to control the bacteria populations you need to control the PH. And to control the PH you need to control all of your enzymes. So minerals and vitamins is like programming language. You can can program any code using them. this is how your body works and all the doctors, researchers recommending certain substances for all imbalances are simply wrong."

Bacterial production of endotoxin is controlled by the type of bacteria in the gut and the food you eat. Controlling pH is not going to somehow magically turn an endotoxi producing bacteria into benign one. If you feed the bacteria with resistant starch, it will produce endotoxin, period. So, all of this controlling of enzymes is just like genetic programming/editing - it is just the epigenetic version of it - i.e. if we know all of the enzymes of the organism we can control all the reactions. The same story was sold about genes. But in the case of genes it turned out they are ALL interconnected so one gene does not really do much on its own, and even then genes did not really turn out to control much anyways. Same with epigenetic enzyme programming. We don't know all of them, new enzymes are being discovered every day, and building some kind of idealized graph with all of these enzymes that somehow can be controlled by finetuning this node or that node is a dream/illusion. We should be working upstream, not downstream.
Iron is not lower in cancer, the medical term is "anemia of chronic disease" but it is not anemia at all, it is iron overload. In this so-called anemia ferritin is high, transferin is low, iron saturation index is high and serum iron MAY be low. But high ferritin and high iron saturation, combined with low transferrin is definition of iron overload, not anemia. That is why iron chelation drugs are being used right now for many cancers.
The role of iron chelation in cancer therapy. - PubMed - NCBI
Iron chelation in the treatment of cancer: a new role for deferasirox? - PubMed - NCBI
Recent advances in cancer treatment by iron chelators - ScienceDirect

True anemia with low iron is called "iron-deficiency anemia" and is characterized by LOW ferritin, low iron saturation, high transferrin and sometimes low serum iron. This type of anemia is common in hypothyroidism and people with chronic bleeding issues. Chronically high cortisol may also cause it, as user @messtafarian found out. She had/has Cushing syndrome just like gbolduev. Btw, gbolduev said in a few threads that he had high ferritin, low transferrin and low serum iron - so "anemia" of chronic disease, which matches his claims that he has/had cancer(s).
You can Google both "anemia of chronic disease" and "iron deficiency anemia" for more info. There are some great resources describing the differences and how unfortunate it is that the first one is called anemia at all when it is fact iron overload.

The crap about studies is quite double-sided I am afraid. On one hand he does not like studies but on the other hand he quotes them when he wants to prove his point, especially when it is about RU486. See below.
Post Finasteride Syndrome, 5ar, And The Brain

Also, he contradicts himself quite a few times. In some threads he thrashes CO2, progesterone, magnesium, etc and in others he says they will be universal cure for PFS.
Post Finasteride Syndrome, 5ar, And The Brain

Furthermore, not sure if you were here 2 years ago when he first started posting here. We had a big discussion in the PaCO2 thread. If you go through it you will see that at the time he was saying copper will NOT work for anyone and Peat is poisoning people with his suggestion to eat copper. The suggestion at the time was to ONLY supplement zinc and manganese but never copper. So, what happened? Why the reversal 180 degrees now, and more importantly, why does he flip flop every 5-10 posts or so? Which version is correct? Now he is pushing copper to almost everyone in the form or seafood or supplements, which is something Peat has been saying all along.

So far I have yet to see anything outside of his own words that adds credibility to the claims about pH controlling endotoxin, serotonin, NAD/NADH ratio, steroid synthesis, etc. If anything, there is plenty of evidence that it is the other way around - endotoxin, serotonin, NAD/NADH ratio, estrogen/progesterone ratio, etc controlling pH. It is probably a loop but to claim so definitively something when just 2 years ago the story was vastly different is suspect. Everybody is wrong most of the time, including me and possibly Peat. But when the claims of one person vary so widely, it makes it hard to follow his guidance as such opposing recommendations can wreak havoc if they are wrong even once. And since they are so opposing we know they will be wrong at least once.
Let's see what happens to the people recovering from RU486. As far as I can see some of them have hair shedding, adrenaline surges, insomnia, and mood swings. A few reported very high prolactin already. If these things do not normalize, then I am afraid the people who jumped on the RU486 bandwagon will end up in a worse position than when they started. I genuinely wish that somebody figures it all out. I don't care if it is gbolduev or if isn't me. But so far it looks like we don't have an answer.
Btw, androsterone elevates 5-AR as per another study I posted. If gbolduev claims it lowers it I would like to see his experiments and how he proved that, not some theoretical lecture from Wilson/Eck which he things is true just because it is logical. As we have seen countless times on this forum, just because something makes sense does not mean it works that way in real life.

Wagner83:
Well he's probably not going to come back now.

I see your point about enzymes, so basically unless we know about all of them and how they all interact there's no way to tell what will happen. If true then that means Eck's work is very obsolete no? Did you ever study it?

To be fair with him it's very rare that he cites studies, but he did a few times.

I quoted this post before but this is more than changing one's mind Post Finasteride Syndrome, 5ar, And The Brain At the time he spoke like he does now, and even when he sees this evidence he has no issues with how arrogant, assertive and wrong he was because now at least he holds the truth. It is very difficult to follow his ideas, I wish he just had explained his main views in two long posts rather than scattering bits everyhwere with a lot of arguing and insults in between. Anyways, hopefully he has the cure for PFS guys, if he does then Eck's work and anesthesiology books may become more interesting to me.

I also hope they recover.

As for supplement or seafood, he recommends very few supplements and short term, these recommendations seem to be all over the place , it seems he would need blood test/hair test to give them but he still suggests things based on forum posts (people push him though). Sea food he says is better because it has minerals and no man-made hormones . As I argued with him fish have 11-keto-dht and T and those obviously are active in humans, but he was afraid of men adding artificial hormones, if one lives in a big city then perhaps wild seafood is the only way to access hormone-free animal proteins.

It's difficult to see anything besides his own words since everything is biochemistry 101, experimented with in his own lab and on his computers, or in anesthesiology books. Those last ones should be worth a read at least, member mattyb seemed to agree with a lot of his views and he had training in the medical field as well.

As for endotoxin, mood etc.. My experience so far is that at the very least 1 BM is needed and 2 means good things start to happen. Not sure if there's a need to control ph and what not, could healthy digestion be the biggest part of the puzzle (before serious issues set in)?

haidut:
For the record, I asked multiple times about which books this is written in, even one single title. None was given of course. I also read a few biochemistry books, including 2 that are used for medical schools in the US. None of them talk about pH controlling disease like he does. Btw, his claim partially matches Peat's writings. One of the pH imbalances is metabolic acidosis - high lactate, low CO2 and low NAD/NADH ratio. And Peat agrees that this is a big issue, especially in cancer and diabetes and that is what most people have as an issue. There are 3 other imbalances but those seem to be rare, both according to Peat and according to the medical literature. For example respiratory acidosis - high CO2, low lactate. This seems to be only present in people with COPD or other lung issues. But gbolduev never explained why he thinks the other pH imbalances are common, in his opinion. He just kept saying pH is the cause of it all. Well, maybe, if by that you mean metabolic acidosis. You see, a lot of what he writes overlaps with Peat. My biggest issue is why not admit that and state where you disagree. But he kept insisting he is anti-Peat in every respect while at the same time recommending copper, acetazolamide, taurine, and anti-glucocorticoid / anti-estrogenic drugs to everybody. It will not make you less respected if it turns out what you preach overlaps with another person. It is the differences that matter, and I was hoping to hear more about those differences.
Anyways, for the record, I never saw any evidence of his own experiments in a lab. Maybe it is hard to provide such evidence but for something like determining whether androsterone is inhibitor or inducer of 5-AR, it should be easy to provide the evidence. Did he use in vitro models, maybe even rodent experiment, and maybe even human ones?? I would have loved to see evidence on androsterone, for or against. But all we got in that thread is an even more autocratic statement like "androsterone inhibits 5-AR. If you don't see that then I can't help you." You may be the rightest person in this world but if make statements like that nobody will take you seriously.
As far as Eck and Wilson, yes I did read a lot of their stuff but it quickly started to sound cultish. When you state that there are 8 metabolic types and you provide no evidence for that it is hard to take that serious. Or when you state that sodium is the "will of God" while potassium is "grace of God" or something like that it is even harder to take seriously their theory.
HIGH SODIUM/POTASSIUM RATIO

I would not call their theory obsolete, I would just call it incomplete in the areas where it is actually medically valid combined with a lot of "metaphysical" stuff which is impossible to prove/disprove and should have no place in a serious book on physiology. I would also call it reductionist, because it assumes all the basic knowledge is already known and a complete theory is possible. Biochemistry, like any science or body of knowledge, is an open system. And it will always be evolving. So far we have no evidence that complete graphs of genes or enzymes explain the human body, let alone predict disease development of provide clues to possible therapies.

Oh well, let's see what says in 6 months or so. I am sure there will be another story at that time. We live we learn

Oh, one more thing - my experience also matches yours in terms of BM. One per day is the minimum for feeling OK. Anything less than that and I get sluggish and feeling unwell. I would say two per day is where I feel like I am back in my 20s and with 3 per day I am back in high school. No theory of pH can explain infrequent BM, but high endotoxin/serotonin/NO can and there are drugs in the pipeline (so far highly successful) which aim to actually cure IBS-C. If that happens, I suspect we will see a lot of other diseases disappear or drop significantly as bowel health seems to be the key to systemic health.

Wagner83:
I agree on all of that, but if I may ask, how/why do you think he can be an interesting and valuable contributors given he makes a lot of claims without substanciating his views, nor providing experiments from his labs (now that would be nice of him), and does not recommend any books? It's even the same for his two cancers and PFS cure, how do we know he got all this and he's not trolling? I don't want proofs he had cancers but given the content of his posts and carater it can become an issue. Like I said about westide, when people do not sound like they are doing well in their posts it is difficult to believe they are healthy. I know he doesn't recommend books because I asked him a few times how to enlighten myself without having to rely on his knowledge (if you look at the advice he gives, all is done to have everyone rely on him from start to finish, that may not be a conscious move), which books taught him all that he knows, but he never answered. His only recommendations were "anesthesiology books" , that this was the one field of medicine based not only on studies but decades of experiments in hospitals and it should be used for all diseases and health issues.
If he states he disagrees with Peat in every ways (Quest For The Perfect Anticatabolic / Anabolic Supplement) perhaps he just lacks the zoomed out / panoramic view that you (and for example tyw) seem to have. However I do not think he recommended any supplements for all, his recommendations changed a lot and should have been based on hair and blood tests. He does disagree with Ray in many aspects, as you said in his opinion enzymes/minerals/PH are the main and upstream players in health, not hormones etc.. He disagrees on the standard Ray Peat diet and as you know so do I (direct experience and people on this forum) except for "fast oxidizers" . I have to say that his skepticism on the lack of context of studies sounds right since a lot of people notice different results from things like dhea, preg, prog etc..

I'm curious about his claims of androsterone, it fits with his contrarian endocrinology and negative feedback ideas on the human body. One thing I'm curious about is if androsterone increases 5-ar and is highly androgenic, how comes women in the Mount Sinai study did not report side effects or masculinization?

I'm not reading that Wilson guy again, I read some of his website (diet etc..) and he sounds mad. Actually gbol also said he was mad. Bicarbonate Vs. PaCO2 Blood Tests
Post Finasteride Syndrome, 5ar, And The Brain
If You Don't Want Low Testosterone DO NOT FAST

haidut:
I am just saying that he has a lot of knowledge and unless he is trolling true knowledge is always valuable even if it is contrarian. It can force people to look at things from a different angle, even if wrong/incomplete. It can also stimulate lurkers with good knowledge who normally do not participate to come forward and get engaged and this is always good. Too bad he engages in a way that is very disruptive for most online communities.

 

[Wagner83]

About lifestyle

Wagner83:
I'd love to find supplements that are not needed long term, from what I read on the forums and online, to keep the benefits of androsterone, thyroid supplementation and what not, people need to keep taking it. In the end it seems to me that either they find dietary and lifestyle fix that solve problems and digestion for good or they use the various patches more or less continuously. Red light could be an interesting tool.

haidut:
I think you hit it on the nail - in order to experience long term improvement that is sustainable and without need for constantly supplementing, a person needs to change their environment. By that I mean both changing the environment they live in OR move to a better environment. There are so many imperceptible things about life that affect us all the time and cannot be controlled individually. I don't know how feasible this would be for most people and I think Ray is in a certain sense very lucky to be able to live a life that he wants to without having to comply with the demands of the modern slavery we all live in. I know he is older and is probably more financially secure and probably does not care as much about trivial matters of life, but then again a lot of the recommendations about diet he makes may not even be necessary (aside from PUFA avoidance) if people simply lived life with more freedom in it. Peat even wrote about it in one of his articles about a guy that was sent to Poland to study the health of the people there and he came back to say that people will not have any disease if their government would simply stop oppressing them. So, to me the best thing a person can do for their health is find a place to live where the interference from authority will be as little as possible.
Cholesterol, longevity, intelligence, and health.
"...But those harmful factors all had their defenders: Who defends socioeconomic stress? All of the social institutions that fail to alleviate it. In 1847, Rudolph Virchow was sent to Poland to study the health situation there, and when he returned, the highly regarded anatomist, physiologist and pathologist announced that the Poles wouldn't have a health problem if the government would stop oppressing them, and institute economic reforms to alleviate their poverty. The reforms weren't made, and Virchow lost his job. Other harmful factors, such as seed oils, degraded foods, and radiation, have specific, very well organized and powerful lobbies to defend them."

The fact that Ray chooses to live most of the time in Mexico where you can be rather free if you have just a little bit more money than the people around you, shows enough. If thyroid and pregnenolone were enough he would be living in the USA most of the time.

 

[Wagner83]

About hair:

Wagner83:
Yeah I know we discussed it, my only question is are minerals and ph balance really downstream or do they form a circle with hormones, liver and thyroid function and the rest . Things like magnesium can be pretty potent. For example I'm still curious about hair loss because my hair look awful and shed a lot, yet I feel better than I did before. I remember being very stressed, eating whole grains and salmon and coming off bad nerve issues with the healthiest shiniest fullest looking hair ever. I think you are balding or bald yourself. This for me makes it hard to believe serotonin and cortisol or estrogens are the only players in hair loss. It also makes it hard to believe hair tests are a great marker for health.

haidut:
I lost a lot of hair over the course of a very short period (maybe 6 months or so) around 2008/2009 when I was at the height of my Paleo days. Since they I regrew at least 50% of it, so I went from almost bald to having a "receding hairline" as the dermatologist I saw called it. The period of most intense hair loss coincided almost perfectly with the period of high cortisol/prolactin/estrogen measured on blood tests, which have since normalized. To me there is no doubt that these hormones cause hair loss, the only disconnect I see with Peat is to what degree this can be reversed. The only person I know of who lost all his hair in a typical MPB pattern and got it ALL back was a mountain climber I knew back in college. He went almost completely bald in his mid-twenties and went to live with a community in the Tian-Shen mountains. I saw him maybe 5 years later and his hair had come back completely. He told me he would never go back to the modern world and there are things he could "feel" in the air, "taste" in the food and "see" around us that he could never explain but were obvious to people who lived in the wild. He said even one of those "things" was enough to cause serious health issues over time. He studied Selye as well and said once the "stress syndrome" starts it can be stopped but not reversed in the modern world we live in. That world is engineered AND optimized for stress and he thought he needed a complete reset to recover. He did seem to recover his hair fully and it did look real (no surgery or fake implants). And he went back to the mountains and seems to not have any interest in coming back. Maybe it is the CO2, maybe it is the freedom he enjoys there. But the difference in how he looked, not just because of hair regrowth, was striking. I don't think I could pull off leaving the civilized world for good, but every once in a while I wonder if there is any point in doing a more extended "reset" like him. Peat keeps going to Mexico and cuts off the world completely for months. There must be a reason for that. He also said a few times that changing places/experiences in a dramatic fashion can change things for good for people who do not respond to anything else.

 

[Wagner83]

Wagner83:
After a few days I felt like a beast on estroban, tolerated stress better (I saw your study on how estrogens allow the deleterious effects of stress to happen), woke up with long lasting fuller ection and then the next day was suddenly too much, it's funny how delicate the balance is.

haidut:
I think this may be the reason Ray uses most supplements sporadically. Either weekly or every 2-3 days. This way you still get a boost but without triggering an adaptation. The human organism is a giant adaptive machine, and I think at least for the steroid we have all experienced that taking every day causes desensitization and a break is needed every once in a while. I think this may be true for most "supplements". When I use Pansterone twice a week I do not get downregulation so maybe you can try the same sporadic use with EstroBan as well.

 

[Dhair]

It is truly mind-boggling to me that @haidut makes time for everyone, with no exceptions. If I had a family, a full time job, and a separate business to run, I would be out of my mind. He is probably the most helpful and special person that I have ever "met" online.