gbolduev said:Haidut
As I mentioned before. I go by my own studies aka blood tests in this case. I collected quite a population for 2 years when I helped people. I am telling you what I saw on the tests. Cortisol is not a problem at all. COrtisol is raised for survival to get you protein when pancreas go down. Serotonin is raised to support brain function. These two have nothing to do with the actual problem
I have no idea what you want from me. I am telling you info that I know for a fact from blood tests. I dont read studies and dont plan to.
One thing I can tell you . Almost none of sick people have high estrogen and 80% of CFS people have low cortisol that is why they take hormones)))
What is there to argue, just test 10 people out here for PTH you will see yourself))) PTH is very rare to be up. VERY VERY RARE. I saw it up may be in 1 case out of 50 in my population.
Also numbers from my case. MY TSH is 0.7 my estrogen is low, my pth is bottom of the range. PUlse 85. Normal temperatures. According to Peat I am super human))))) WRONG I had major major problems when I had these tests.
You are wrong, if you are not getting protein inside you need to stop catabolic state? You need to get protein but in a different way.
I never said cortisol or serotonin being elevated is good. NOthing low or high is good. I say BALANCE.
I say that cortisol and serotonin dont have anything to do with aging at all. These are raised in certain situations to save you. But they are raised for purpose not as a mistake.
the real problem is your pancreas or gastrin, which stops you from digesting protein properly. Then you have high cortisol at first and then when you get depleted of muscles you will get low cortisol like all people with CFS. and feeding more protein does nothing in this case. NOTHING
Really sick people have low cortisol not high. YOu know why? Since they dont have any protein left in their body , cortisol is lowered. But if your pancreas are not working correctly and you lower your high cortisol, you will get liver toxicity since you wont make any systemic proteins like ferritin or ceruloplasmin
That is when you are sick you need to get aminos that dont require digestion.
As far as projections to the world . I am into algorithmic trading, I dont project , I get data and I look at it myself. I dont talk from my case at all. I saw many many many blood work cases to even open my mouth. How many actual tests have you done? And how many people did you observe.
For me Ray Peat projects one case to the world which is major wrong. And even from this forum you can see that his diet helps at best 50% of people.
I dont tell all people to do the same thing. I tell people to get tested and see for themselves that in at least 50% cases PEAT is wrong. I would say in 80% from my little population. ( 100 people with ABGs) and blood work. And about 1000 people with blood work and hairtests.
So I project nothing, I project truth. And truth is you go and get tested and you will see that I am right.
I will not go and look for some studies i just go to the lab instead. See the difference. That is major problem in the US. In the US you have problems to get tested for simplest stuff and that is why people prefer to try stuff out without even knowing where they are and blindly trusting Peat like gurus.
We argue about simple things, I have no idea why though. They should be obvious to any researcher. It is not about studies, it is about understanding of how everything works. YOu can find studies to fit any theory. Hey when I started I was like that, I could find any studies to fit any of my theories. And the ones that dont fit it I would try to explain somehow. LIke niacinamide does not raise serotonin, oh but it raises uptake and so forth)))) it goes on and on . YOu go and test yourself at least first . Then you test at least 10 people you know . And even from this little population you will see that all these gurus know nothing. And that it is way more complex. One guy drinks alcohol and another smokes cigarettes, third lifts , and another one jerks off non stop. ALL of them have the same chemistry? LMAO of course not and diets will be different, since they are screwing their balance in different ways.
I cant direct you in the location for you to find and confirm what I am saying in studies I dont read studies any more at all, I used to ,and beileve me I know most of the studies you reference, I even had huge collection of them for every body system.But to confirm what I am saying Sorry, it simply does not exist. I am giving you this information for no cost from my heart and I swear that what |I am saying is the truth. Maybe my population is not big, but it is something real, at least for me. these are the results that I got and no one can take this away from me. I am not selling anything to anyone, and I am not giving advice or helping anyone. I am not in this field at all now. It has nothing to do with my experience I only pass on what I got on these tests. You make your own conclusions. I made my own .
Good luck , buddy
OK, thanks for explaining. As for me, I also speak from experience even though not very extensinve. I currently volunteer for an organization that does clinical studies on experimental drugs and have access to medical data collected from patients. So, from that data I see that in most people over 30 there is vitamin D deficiency and consequently their PTH is either high normal or elevated. Given PTH relationship to insulin sensitivity, this shows one reason why many people over 30 have problem with sugar and weight gain. Elevated PTH makes you insulin reistant, and bringing it down alleviates the rpoblem fo rmany people.
So, that's my data. I am just saying that in "my" population that tends to be tens of thousands of people from all over the world these are the things I see - i.e. low vitamin D, high/normal PTH and sometimes elevated calcium.
For pancreas - I fully agree with you that protein deficiency is a problem and the pancreas may be a direct cause of that. So, 2 questions here. What do you think the problem with the pancreas may be, and how it can be fixed? Second question is why is the pancreatic problem the issue and not itself a result of a more generic systemic failure related to energy production?
I don't think we are arguing, I think we simply favor two different explanations to the same problem. Only thing I ask is for your explanation why most problems we see people face could not be a result of energetic failure rather than some specific organ dysfunction. If it was simple pancreas failure, people get digestive enzymes and protein digestion recovers. However, for sick people this does not seem to be the case. Digestive enzymes do not help and they continue to break down aminos like tryptophan in the IDO pathway and get toxic metabolites. So, why is that the case? I don't think it is pancreas problem only.
Thanks and good luck to you too.