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Too Much Ashwagandha, Now Serotonin Syndrome? Please Help

Discussion in 'Cortisol, Serotonin, Histamine' started by edd00, Jul 29, 2018.

  1. bboone

    bboone Member

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    why would this work? i'm not saying it won't, i'm just curious as to the mechanism.
     
  2. Alpha

    Alpha Member

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    It's a serotonin receptor antagonist.
     
  3. Andman

    Andman Member

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    metergoline has been tried for PSSD with mixed results
     
  4. Alpha

    Alpha Member

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    Both are selective serotonin receptor antagonists. It's not the same thing.
     
  5. Andman

    Andman Member

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    not sure im following, please explain ‍♂️
     
  6. Alpha

    Alpha Member

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    They don't target the same receptors.
     
  7. bboone

    bboone Member

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    if the receptor is already desensitized, wouldn’t an antagonist cause further desensizitation and so exacerbate the issue? the wikipedia page says activation of the receptor causes dopamine release in the prefontal cortex, so wouldn’t antagonism reduce dopamine expression?

    one thing i find strange is that the wikipedia page says activation of the 5ht1A receptor facilitates sexual arousal but inhibits penile erection. is this a mistake...?
     
  8. Andman

    Andman Member

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  9. Lokzo

    Lokzo Member

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    Has this helped you? Does it specifically address the 5HT1a dysfunction we are experiencing?
     
  10. Lokzo

    Lokzo Member

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    I may have FINALLY resolved this issue, after YEARS of suffering from PSSD-Like symptoms from Ashwagandha.

    I started using St. Johns Wort, for 5HT1-a up-regulation, whilst simultaneously using ZEOLITE (Which increases sensitivity of the 5-HT1A receptor) and it appears that this has REALLY helped. Like I can feel again.

    During this time I also used Cistus Incatus tea (Aiding detoxification) and also C-60 Fullerene in olive oil.

    I hope this continues to stay positive.

    I thought I was doomed for life after my experience with Ashwaganhda....
     
  11. Alpha

    Alpha Member

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    Antagonists usually resensitize receptors because you're giving them the binding signal with weak agnostic properties.

    It's not that simple. Not all 5-HT1 receptors function the same, it's location dependent. Some are autoreceptors, some aren't.
     
  12. Lokzo

    Lokzo Member

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    When I'm under the influence of Zeolite, I notice all my sensation returns, libido comes back full strength, and mood is boosted.
     
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