Mitchell777
Member
- Joined
- Oct 25, 2019
- Messages
- 27
A new oral testosterone (TLANDO) treatment regimen without dose titration requirement for male hypogonadism
The study uses a formulation consisting of testosterone undecanoate in a quote “unique lipid formulation containing predominantly predigested triglycerides (mono‐ or di‐glycerides)” The study authors said exactly what Peat said decades ago for his original formula for Progest-E, describing how steroids can overcome poor bioavailability by avoiding first pass metabolism via the lymphatic route, quote “designed to enable absorption of TU via the intestinal lymphatic pathway…avoiding the first‐pass metabolism”
The study also says how non‐esterified T has very poor bioavailability as it is extensively metabolized through first‐pass metabolism. However, surly if Peats formula with progesterone dissolved in tocopherol and coconut oil was replicated with a slight change, by simply replacing the progesterone with testosterone, similar results and therefore oral bioavailability would be seen?
My biggest question however is, how much effect would the undecanoate ester have on oral bioavailability, as the study’s formula adds a lipid formulation (predigested triglycerides (mono‐ or di‐glycerides) to esterified-testosterone, raising the question of would testosterone base, dissolved in Peats tocopherol / coconut oil mixture share similar or potentially even better oral bioavailability and therefore results as the esterified testosterone with their “unique” lipid formulation? Obviously a preferred lipid / solvent would the tocopherol and coconut oil / MCT oil.
I thought the study would be a good discussion point considering we are now seeing more attempts to create an effective oral TRT / Testosterone formulation, JATENZO being the other recent oral testosterone formula coming to my mind.
It’s a shame that none of these studies are using testosterone base it Peats tocopherol / coconut oil formulation and then conducting these same testing methods, measuring serum levels after say 225mg orally twice a day like the TLANDO product which this new study is using. Also measuring subsequent estrogen levels would be key to see how much of the exogenous testosterone would be aromatising. This would then give us a much clearer picture into how much oral testosterone can be administered without severe aromatisation, leading to unwanted results.
The study uses a formulation consisting of testosterone undecanoate in a quote “unique lipid formulation containing predominantly predigested triglycerides (mono‐ or di‐glycerides)” The study authors said exactly what Peat said decades ago for his original formula for Progest-E, describing how steroids can overcome poor bioavailability by avoiding first pass metabolism via the lymphatic route, quote “designed to enable absorption of TU via the intestinal lymphatic pathway…avoiding the first‐pass metabolism”
The study also says how non‐esterified T has very poor bioavailability as it is extensively metabolized through first‐pass metabolism. However, surly if Peats formula with progesterone dissolved in tocopherol and coconut oil was replicated with a slight change, by simply replacing the progesterone with testosterone, similar results and therefore oral bioavailability would be seen?
My biggest question however is, how much effect would the undecanoate ester have on oral bioavailability, as the study’s formula adds a lipid formulation (predigested triglycerides (mono‐ or di‐glycerides) to esterified-testosterone, raising the question of would testosterone base, dissolved in Peats tocopherol / coconut oil mixture share similar or potentially even better oral bioavailability and therefore results as the esterified testosterone with their “unique” lipid formulation? Obviously a preferred lipid / solvent would the tocopherol and coconut oil / MCT oil.
I thought the study would be a good discussion point considering we are now seeing more attempts to create an effective oral TRT / Testosterone formulation, JATENZO being the other recent oral testosterone formula coming to my mind.
It’s a shame that none of these studies are using testosterone base it Peats tocopherol / coconut oil formulation and then conducting these same testing methods, measuring serum levels after say 225mg orally twice a day like the TLANDO product which this new study is using. Also measuring subsequent estrogen levels would be key to see how much of the exogenous testosterone would be aromatising. This would then give us a much clearer picture into how much oral testosterone can be administered without severe aromatisation, leading to unwanted results.
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